Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment.
Identifieur interne : 002D15 ( Ncbi/Checkpoint ); précédent : 002D14; suivant : 002D16Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment.
Auteurs : Alberto J. Espay [États-Unis] ; Dominic C. Paviour ; John D. O'Sullivan ; Robert E. Schmidt ; Fredy J. Revilla ; Leo Verhagen MetmanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adolescent, Brain (surgery), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Cognition Disorders (therapy), Deep Brain Stimulation, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (physiopathology), Female, Humans, Intranuclear Inclusion Bodies, Levodopa (adverse effects), Levodopa (therapeutic use), Magnetic Resonance Imaging, Neurodegenerative Diseases (complications), Neurodegenerative Diseases (diagnosis), Neurodegenerative Diseases (physiopathology), Neurodegenerative Diseases (therapy), Parkinsonian Disorders (etiology), Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (therapy), Young Adult.
- MESH :
- chemical , adverse effects : Levodopa.
- complications : Neurodegenerative Diseases.
- diagnosis : Dyskinesia, Drug-Induced, Neurodegenerative Diseases.
- etiology : Cognition Disorders, Parkinsonian Disorders.
- physiopathology : Cognition Disorders, Dyskinesia, Drug-Induced, Neurodegenerative Diseases, Parkinsonian Disorders.
- surgery : Brain.
- chemical , therapeutic use : Levodopa.
- therapy : Cognition Disorders, Neurodegenerative Diseases, Parkinsonian Disorders.
- Adolescent, Deep Brain Stimulation, Female, Humans, Intranuclear Inclusion Bodies, Magnetic Resonance Imaging, Young Adult.
Abstract
A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.
DOI: 10.1002/mds.23194
PubMed: 20669183
Affiliations:
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Paviour</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Schmidt, Robert E" sort="Schmidt, Robert E" uniqKey="Schmidt R" first="Robert E" last="Schmidt">Robert E. Schmidt</name></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23194</idno><idno type="RBID">pubmed:20669183</idno><idno type="pmid">20669183</idno><idno type="wicri:Area/PubMed/Corpus">001702</idno><idno type="wicri:Area/PubMed/Curation">001702</idno><idno type="wicri:Area/PubMed/Checkpoint">001812</idno><idno type="wicri:Area/Ncbi/Merge">002D15</idno><idno type="wicri:Area/Ncbi/Curation">002D15</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment.</title><author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio, USA. espayaj@ucmail.uc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, UC Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Paviour, Dominic C" sort="Paviour, Dominic C" uniqKey="Paviour D" first="Dominic C" last="Paviour">Dominic C. Paviour</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Schmidt, Robert E" sort="Schmidt, Robert E" uniqKey="Schmidt R" first="Robert E" last="Schmidt">Robert E. Schmidt</name></author><author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Brain (surgery)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (physiopathology)</term><term>Cognition Disorders (therapy)</term><term>Deep Brain Stimulation</term><term>Dyskinesia, Drug-Induced (diagnosis)</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Female</term><term>Humans</term><term>Intranuclear Inclusion Bodies</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Imaging</term><term>Neurodegenerative Diseases (complications)</term><term>Neurodegenerative Diseases (diagnosis)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurodegenerative Diseases (therapy)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Parkinsonian Disorders (therapy)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Dyskinesia, Drug-Induced</term><term>Neurodegenerative Diseases</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term><term>Neurodegenerative Diseases</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Intranuclear Inclusion Bodies</term><term>Magnetic Resonance Imaging</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name><name sortKey="Paviour, Dominic C" sort="Paviour, Dominic C" uniqKey="Paviour D" first="Dominic C" last="Paviour">Dominic C. Paviour</name><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name><name sortKey="Schmidt, Robert E" sort="Schmidt, Robert E" uniqKey="Schmidt R" first="Robert E" last="Schmidt">Robert E. Schmidt</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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