Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Identifieur interne : 002014 ( Main/Merge ); précédent : 002013; suivant : 002015Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Auteurs : Susanne A. Schneider [Royaume-Uni, Allemagne] ; Burkhard Pleger [Royaume-Uni, Allemagne] ; Bogdan Draganski [Royaume-Uni, Allemagne] ; Carla Cordivari [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Ray J. Dolan [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Brain Mapping, Discrimination (Psychology) (physiology), Dystonic Disorders (pathology), Dystonic Disorders (physiopathology), Evoked Potentials, Somatosensory (physiology), Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen (blood), Somatosensory Cortex (blood supply), Somatosensory Cortex (physiopathology), Statistics, Nonparametric, TMS, Transcranial Magnetic Stimulation (methods), basal ganglia, fMRI, premotor cortex, primary dystonia, repetitive TMS, sensorimotor cortex, sensory discrimination, writer's cramp.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Somatosensory Cortex.
- methods : Image Processing, Computer-Assisted, Transcranial Magnetic Stimulation.
- pathology : Dystonic Disorders.
- physiology : Discrimination (Psychology), Evoked Potentials, Somatosensory.
- physiopathology : Dystonic Disorders, Somatosensory Cortex.
- Adult, Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Statistics, Nonparametric.
Abstract
Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A00257E644BA6906FB30146744D4A341941D570A/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929458
DOI: 10.1002/mds.22825
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<term>Transcranial Magnetic Stimulation (methods)</term>
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<term>premotor cortex</term>
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<front><div type="abstract" xml:lang="en">Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society</div>
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<wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea>
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<series><title level="j">Movement Disorders</title>
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<term>basal ganglia</term>
<term>fMRI</term>
<term>premotor cortex</term>
<term>primary dystonia</term>
<term>repetitive TMS</term>
<term>sensorimotor cortex</term>
<term>sensory discrimination</term>
<term>writer's cramp</term>
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<front><div type="abstract" xml:lang="en">Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society</div>
</front>
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<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia – an fMRI-TMS study</title>
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<affiliation wicri:level="1"><nlm:aff id="A2"> Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck, Germany</nlm:aff>
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<wicri:regionArea> Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, Leipzig</wicri:regionArea>
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<author><name sortKey="Cordivari, C" sort="Cordivari, C" uniqKey="Cordivari C" first="C" last="Cordivari">C. Cordivari</name>
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<author><name sortKey="Rothwell, Jc" sort="Rothwell, Jc" uniqKey="Rothwell J" first="Jc" last="Rothwell">Jc Rothwell</name>
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<author><name sortKey="Dolan, Rj" sort="Dolan, Rj" uniqKey="Dolan R" first="Rj" last="Dolan">Rj Dolan</name>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain Mapping</term>
<term>Discrimination (Psychology) (physiology)</term>
<term>Dystonic Disorders (pathology)</term>
<term>Dystonic Disorders (physiopathology)</term>
<term>Evoked Potentials, Somatosensory (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted (methods)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Oxygen (blood)</term>
<term>Somatosensory Cortex (blood supply)</term>
<term>Somatosensory Cortex (physiopathology)</term>
<term>Statistics, Nonparametric</term>
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</keywords>
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<term>Transcranial Magnetic Stimulation</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
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<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P3">Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for non-invasive stimulation of the human cortex and can alter cortical excitability and associated behaviour. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P4">We applied 5Hz-rTMS over the left primary somatosensory cortex (S1) in 5 patients with right-sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS-induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P5">Prior to rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task-related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P6">Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG-S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task.</p>
</sec>
</div>
</front>
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