Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Identifieur interne : 000696 ( Istex/Curation ); précédent : 000695; suivant : 000697Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
Auteurs : Susanne A. Schneider [Royaume-Uni, Allemagne] ; Burkhard Pleger [Royaume-Uni, Allemagne] ; Bogdan Draganski [Royaume-Uni, Allemagne] ; Carla Cordivari [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Ray J. Dolan [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
English descriptors
- KwdEn :
Abstract
Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22825
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000696
Links to Exploration step
ISTEX:A00257E644BA6906FB30146744D4A341941D570ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study</title><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck</wicri:regionArea></affiliation></author><author><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Draganski, Bogdan" sort="Draganski, Bogdan" uniqKey="Draganski B" first="Bogdan" last="Draganski">Bogdan Draganski</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><affiliation wicri:level="1"><mods:affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Dolan, Ray J" sort="Dolan, Ray J" uniqKey="Dolan R" first="Ray J." last="Dolan">Ray J. Dolan</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A00257E644BA6906FB30146744D4A341941D570A</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22825</idno><idno type="url">https://api.istex.fr/document/A00257E644BA6906FB30146744D4A341941D570A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000696</idno><idno type="wicri:Area/Istex/Curation">000696</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study</title><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Schilling Section of Clinical and Molecular Neurogenetics, University of Luebeck</wicri:regionArea></affiliation></author><author><name sortKey="Pleger, Burkhard" sort="Pleger, Burkhard" uniqKey="Pleger B" first="Burkhard" last="Pleger">Burkhard Pleger</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Draganski, Bogdan" sort="Draganski, Bogdan" uniqKey="Draganski B" first="Bogdan" last="Draganski">Bogdan Draganski</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig</wicri:regionArea></affiliation></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><affiliation wicri:level="1"><mods:affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation wicri:level="1"><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Hospital for Neurology and Neurosurgery, Queen Square, UCLH, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Dolan, Ray J" sort="Dolan, Ray J" uniqKey="Dolan R" first="Ray J." last="Dolan">Ray J. Dolan</name><affiliation wicri:level="1"><mods:affiliation>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Kailash P. Bhatia, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.KRay J. Dolan, Wellcome Trust Center for Neuroimaging, UCL, Queen Square, London</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-15">2010-01-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="76">76</biblScope><biblScope unit="page" to="83">83</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A00257E644BA6906FB30146744D4A341941D570A</idno><idno type="DOI">10.1002/mds.22825</idno><idno type="ArticleID">MDS22825</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>TMS</term><term>basal ganglia</term><term>fMRI</term><term>premotor cortex</term><term>primary dystonia</term><term>repetitive TMS</term><term>sensorimotor cortex</term><term>sensory discrimination</term><term>writer's cramp</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz‐rTMS over the left primary somatosensory cortex (S1) in 5 patients with right‐sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS‐induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task‐related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG‐S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000696 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000696 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:A00257E644BA6906FB30146744D4A341941D570A
|texte= Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia—An fMRI‐TMS study
}}
| This area was generated with Dilib version V0.6.23. |  |