Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study
Identifieur interne : 001084 ( Main/Merge ); précédent : 001083; suivant : 001085Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study
Auteurs : Line Kenborg [Danemark] ; Christina Funch Lassen [Danemark] ; Johnni Hansen [Danemark] ; Jorgen H. Olsen [Danemark]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
It has been hypothesized that welders are at increased risk for neurological disorders, including Parkinson's disease, but few well-designed cohort studies have been conducted. The risk for Parkinson's disease and other neurodegenerative disorders was examined in an updated follow-up study based on a previous cohort of 5867 Danish welders and 1735 non-welding metal workers exposed to welding fume. Occupational history and information on smoking were obtained from questionnaires, supplemented by information from the compulsory Danish Supplementary Pension Fund. Hospital contacts, including outpatient data from 1994, for Parkinson's disease and other neurological disorders were ascertained from the Danish National Hospital Register. Based on first-time hospital contacts, standardized hospitalization ratios (SHRs) were calculated for the entire cohort and for welders, metal workers, and nonresponders separately and for the general Danish population in 1987-2008. In an internal analysis of welders, Cox proportional hazard models were used to estimate hospitalization rate ratios (HRRs) for Parkinson's disease associated with lifelong exposure to welding. Overall, 45 cohort members had a hospital contact for Parkinson's disease (SHR, 1.12; 95% confidence interval [CI], 0.82-1.50), of whom 25 were welders (standardized incidence rate ratio, 1.05; 95% CI, 0.68-1.55). When duration of welding was compared among 5736 welders, the HRR was 0.83 (95% CI, 0.59-1.16) per 10 years' welding, after adjustment for smoking. The results of this study do not support the hypothesis that welders are at increased risk for Parkinson's disease; these findings are consistent with those of our previously published analysis.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000092
- to stream PascalFrancis, to step Curation: 002C22
- to stream PascalFrancis, to step Checkpoint: 000105
Links to Exploration step
Pascal:12-0369634Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study</title>
<author><name sortKey="Kenborg, Line" sort="Kenborg, Line" uniqKey="Kenborg L" first="Line" last="Kenborg">Line Kenborg</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Funch Lassen, Christina" sort="Funch Lassen, Christina" uniqKey="Funch Lassen C" first="Christina" last="Funch Lassen">Christina Funch Lassen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0369634</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0369634 INIST</idno>
<idno type="RBID">Pascal:12-0369634</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000092</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002C22</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000105</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Kenborg L:parkinson:s:disease</idno>
<idno type="wicri:Area/Main/Merge">001084</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study</title>
<author><name sortKey="Kenborg, Line" sort="Kenborg, Line" uniqKey="Kenborg L" first="Line" last="Kenborg">Line Kenborg</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Funch Lassen, Christina" sort="Funch Lassen, Christina" uniqKey="Funch Lassen C" first="Christina" last="Funch Lassen">Christina Funch Lassen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Danish Cancer Society Research Center, Danish Cancer Society</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cohort study</term>
<term>Epidemiology</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Etude cohorte</term>
<term>Epidémiologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It has been hypothesized that welders are at increased risk for neurological disorders, including Parkinson's disease, but few well-designed cohort studies have been conducted. The risk for Parkinson's disease and other neurodegenerative disorders was examined in an updated follow-up study based on a previous cohort of 5867 Danish welders and 1735 non-welding metal workers exposed to welding fume. Occupational history and information on smoking were obtained from questionnaires, supplemented by information from the compulsory Danish Supplementary Pension Fund. Hospital contacts, including outpatient data from 1994, for Parkinson's disease and other neurological disorders were ascertained from the Danish National Hospital Register. Based on first-time hospital contacts, standardized hospitalization ratios (SHRs) were calculated for the entire cohort and for welders, metal workers, and nonresponders separately and for the general Danish population in 1987-2008. In an internal analysis of welders, Cox proportional hazard models were used to estimate hospitalization rate ratios (HRRs) for Parkinson's disease associated with lifelong exposure to welding. Overall, 45 cohort members had a hospital contact for Parkinson's disease (SHR, 1.12; 95% confidence interval [CI], 0.82-1.50), of whom 25 were welders (standardized incidence rate ratio, 1.05; 95% CI, 0.68-1.55). When duration of welding was compared among 5736 welders, the HRR was 0.83 (95% CI, 0.59-1.16) per 10 years' welding, after adjustment for smoking. The results of this study do not support the hypothesis that welders are at increased risk for Parkinson's disease; these findings are consistent with those of our previously published analysis.</div>
</front>
</TEI>
<affiliations><list><country><li>Danemark</li>
</country>
<region><li>Hovedstaden</li>
</region>
<settlement><li>Copenhague</li>
</settlement>
</list>
<tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Kenborg, Line" sort="Kenborg, Line" uniqKey="Kenborg L" first="Line" last="Kenborg">Line Kenborg</name>
</region>
<name sortKey="Funch Lassen, Christina" sort="Funch Lassen, Christina" uniqKey="Funch Lassen C" first="Christina" last="Funch Lassen">Christina Funch Lassen</name>
<name sortKey="Hansen, Johnni" sort="Hansen, Johnni" uniqKey="Hansen J" first="Johnni" last="Hansen">Johnni Hansen</name>
<name sortKey="Olsen, Jorgen H" sort="Olsen, Jorgen H" uniqKey="Olsen J" first="Jorgen H." last="Olsen">Jorgen H. Olsen</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001084 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001084 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= Pascal:12-0369634 |texte= Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |