MovDisordV3, PascalFrancis, Curation, bibRecord, 002C22

Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study

Identifieur interne : 002C22 ( PascalFrancis/Curation ); précédent : 002C21; suivant : 002C23

Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study

Auteurs : Line Kenborg [Danemark] ; Christina Funch Lassen [Danemark] ; Johnni Hansen [Danemark] ; Jorgen H. Olsen [Danemark]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0369634

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Etude cohorte, Epidémiologie.

English descriptors

KwdEn :
- Cohort study, Epidemiology, Nervous system diseases, Parkinson disease.

Abstract

It has been hypothesized that welders are at increased risk for neurological disorders, including Parkinson's disease, but few well-designed cohort studies have been conducted. The risk for Parkinson's disease and other neurodegenerative disorders was examined in an updated follow-up study based on a previous cohort of 5867 Danish welders and 1735 non-welding metal workers exposed to welding fume. Occupational history and information on smoking were obtained from questionnaires, supplemented by information from the compulsory Danish Supplementary Pension Fund. Hospital contacts, including outpatient data from 1994, for Parkinson's disease and other neurological disorders were ascertained from the Danish National Hospital Register. Based on first-time hospital contacts, standardized hospitalization ratios (SHRs) were calculated for the entire cohort and for welders, metal workers, and nonresponders separately and for the general Danish population in 1987-2008. In an internal analysis of welders, Cox proportional hazard models were used to estimate hospitalization rate ratios (HRRs) for Parkinson's disease associated with lifelong exposure to welding. Overall, 45 cohort members had a hospital contact for Parkinson's disease (SHR, 1.12; 95% confidence interval [CI], 0.82-1.50), of whom 25 were welders (standardized incidence rate ratio, 1.05; 95% CI, 0.68-1.55). When duration of welding was compared among 5736 welders, the HRR was 0.83 (95% CI, 0.59-1.16) per 10 years' welding, after adjustment for smoking. The results of this study do not support the hypothesis that welders are at increased risk for Parkinson's disease; these findings are consistent with those of our previously published analysis.

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Pascal:12-0369634

Le document en format XML

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<front><div type="abstract" xml:lang="en">It has been hypothesized that welders are at increased risk for neurological disorders, including Parkinson's disease, but few well-designed cohort studies have been conducted. The risk for Parkinson's disease and other neurodegenerative disorders was examined in an updated follow-up study based on a previous cohort of 5867 Danish welders and 1735 non-welding metal workers exposed to welding fume. Occupational history and information on smoking were obtained from questionnaires, supplemented by information from the compulsory Danish Supplementary Pension Fund. Hospital contacts, including outpatient data from 1994, for Parkinson's disease and other neurological disorders were ascertained from the Danish National Hospital Register. Based on first-time hospital contacts, standardized hospitalization ratios (SHRs) were calculated for the entire cohort and for welders, metal workers, and nonresponders separately and for the general Danish population in 1987-2008. In an internal analysis of welders, Cox proportional hazard models were used to estimate hospitalization rate ratios (HRRs) for Parkinson's disease associated with lifelong exposure to welding. Overall, 45 cohort members had a hospital contact for Parkinson's disease (SHR, 1.12; 95% confidence interval [CI], 0.82-1.50), of whom 25 were welders (standardized incidence rate ratio, 1.05; 95% CI, 0.68-1.55). When duration of welding was compared among 5736 welders, the HRR was 0.83 (95% CI, 0.59-1.16) per 10 years' welding, after adjustment for smoking. The results of this study do not support the hypothesis that welders are at increased risk for Parkinson's disease; these findings are consistent with those of our previously published analysis.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study

Parkinson's Disease and Other Neurodegenerative Disorders Among Welders: A Danish Cohort Study

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Descripteurs français

English descriptors

Abstract

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