Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women
Identifieur interne : 000F43 ( Main/Merge ); précédent : 000F42; suivant : 000F44Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women
Auteurs : N. Palacios [États-Unis] ; X. Gao [États-Unis] ; E. O Eilly [États-Unis] ; M. Schwarzschild ; M. L. Mccullough [États-Unis] ; T. Mayo [États-Unis] ; S. M. Gapstur [États-Unis] ; A. Ascherio [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Aged, Alcohol Drinking (epidemiology), Alcoholic Beverages, Beer, Coffee, Cohort Studies, Diet, Educational Status, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nutritional Status, Parkinson Disease (epidemiology), Proportional Hazards Models, Prospective Studies, Questionnaires, Risk, Sex Factors, Smoking (epidemiology), Socioeconomic Factors, United States (epidemiology), Wine.
- MESH :
- chemical : Coffee.
- geographic , epidemiology : United States.
- epidemiology : Alcohol Drinking, Parkinson Disease, Smoking.
- Aged, Alcoholic Beverages, Beer, Cohort Studies, Diet, Educational Status, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nutritional Status, Proportional Hazards Models, Prospective Studies, Questionnaires, Risk, Sex Factors, Socioeconomic Factors, Wine.
Abstract
Addictive behaviors such as cigarette smoking and coffee drinking have been associated with a reduced risk of Parkinson disease. Whether alcohol consumption is also associated with risk is less certain.
We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of Parkinson Disease (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, smoking and other risk factors.
Alcohol consumption was not significantly associated with Parkinson Disease risk. After adjustment for age, smoking, and other risk factors, the Relative Risk comparing men consuming 30 or more grams of alcohol (highest category) to non-drinker men was 1.29 (95% CI: 0.90, 1.86,
The results of this large prospective study do not support an association between alcohol intake and risk of Parkinson disease.
Url:
DOI: 10.1002/mds.25050
PubMed: 22714720
PubMed Central: 3548327
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PMC:3548327Le document en format XML
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<term>Coffee</term>
<term>Cohort Studies</term>
<term>Diet</term>
<term>Educational Status</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutritional Status</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Questionnaires</term>
<term>Risk</term>
<term>Sex Factors</term>
<term>Smoking (epidemiology)</term>
<term>Socioeconomic Factors</term>
<term>United States (epidemiology)</term>
<term>Wine</term>
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<term>Parkinson Disease</term>
<term>Smoking</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Alcoholic Beverages</term>
<term>Beer</term>
<term>Cohort Studies</term>
<term>Diet</term>
<term>Educational Status</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutritional Status</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Questionnaires</term>
<term>Risk</term>
<term>Sex Factors</term>
<term>Socioeconomic Factors</term>
<term>Wine</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Addictive behaviors such as cigarette smoking and coffee drinking have been associated with a reduced risk of Parkinson disease. Whether alcohol consumption is also associated with risk is less certain.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of Parkinson Disease (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, smoking and other risk factors.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Alcohol consumption was not significantly associated with Parkinson Disease risk. After adjustment for age, smoking, and other risk factors, the Relative Risk comparing men consuming 30 or more grams of alcohol (highest category) to non-drinker men was 1.29 (95% CI: 0.90, 1.86, <italic>p-trend</italic>
: 0.40) and the Relative Risk comparing women consuming 15 or more grams of alcohol (highest category) per day to non-drinker women was 0.77 (95% CI: 0.41, 1.45, <italic>p-trend</italic>
: 0.87). Consumption of beer, wine or liquor was also not associated with Parkinson Disease risk.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The results of this large prospective study do not support an association between alcohol intake and risk of Parkinson disease.</p>
</sec>
</div>
</front>
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