MovDisordV3, Main, Merge, bibRecord, 000F43

Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women

Identifieur interne : 000F43 ( Main/Merge ); précédent : 000F42; suivant : 000F44

Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women

Auteurs : N. Palacios [États-Unis] ; X. Gao [États-Unis] ; E. O Eilly [États-Unis] ; M. Schwarzschild ; M. L. Mccullough [États-Unis] ; T. Mayo [États-Unis] ; S. M. Gapstur [États-Unis] ; A. Ascherio [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.

RBID : PMC:3548327

Descripteurs français

Wicri :
- geographic : États-Unis.

English descriptors

KwdEn :
- Aged, Alcohol Drinking (epidemiology), Alcoholic Beverages, Beer, Coffee, Cohort Studies, Diet, Educational Status, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nutritional Status, Parkinson Disease (epidemiology), Proportional Hazards Models, Prospective Studies, Questionnaires, Risk, Sex Factors, Smoking (epidemiology), Socioeconomic Factors, United States (epidemiology), Wine.
MESH :
- chemical : Coffee.
- geographic , epidemiology : United States.
- epidemiology : Alcohol Drinking, Parkinson Disease, Smoking.
- Aged, Alcoholic Beverages, Beer, Cohort Studies, Diet, Educational Status, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nutritional Status, Proportional Hazards Models, Prospective Studies, Questionnaires, Risk, Sex Factors, Socioeconomic Factors, Wine.

Abstract

Background

Addictive behaviors such as cigarette smoking and coffee drinking have been associated with a reduced risk of Parkinson disease. Whether alcohol consumption is also associated with risk is less certain.

Methods

We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of Parkinson Disease (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, smoking and other risk factors.

Results

Alcohol consumption was not significantly associated with Parkinson Disease risk. After adjustment for age, smoking, and other risk factors, the Relative Risk comparing men consuming 30 or more grams of alcohol (highest category) to non-drinker men was 1.29 (95% CI: 0.90, 1.86, p-trend: 0.40) and the Relative Risk comparing women consuming 15 or more grams of alcohol (highest category) per day to non-drinker women was 0.77 (95% CI: 0.41, 1.45, p-trend: 0.87). Consumption of beer, wine or liquor was also not associated with Parkinson Disease risk.

Conclusions

The results of this large prospective study do not support an association between alcohol intake and risk of Parkinson disease.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548327

DOI: 10.1002/mds.25050
PubMed: 22714720
PubMed Central: 3548327

Links to Exploration step

PMC:3548327

Le document en format XML

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<term>Coffee</term>
<term>Cohort Studies</term>
<term>Diet</term>
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<term>Proportional Hazards Models</term>
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<term>Alcoholic Beverages</term>
<term>Beer</term>
<term>Cohort Studies</term>
<term>Diet</term>
<term>Educational Status</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nutritional Status</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Questionnaires</term>
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<term>Sex Factors</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Addictive behaviors such as cigarette smoking and coffee drinking have been associated with a reduced risk of Parkinson disease. Whether alcohol consumption is also associated with risk is less certain.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of Parkinson Disease (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, smoking and other risk factors.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Alcohol consumption was not significantly associated with Parkinson Disease risk. After adjustment for age, smoking, and other risk factors, the Relative Risk comparing men consuming 30 or more grams of alcohol (highest category) to non-drinker men was 1.29 (95% CI: 0.90, 1.86, <italic>p-trend</italic>
: 0.40) and the Relative Risk comparing women consuming 15 or more grams of alcohol (highest category) per day to non-drinker women was 0.77 (95% CI: 0.41, 1.45, <italic>p-trend</italic>
: 0.87). Consumption of beer, wine or liquor was also not associated with Parkinson Disease risk.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The results of this large prospective study do not support an association between alcohol intake and risk of Parkinson disease.</p>
</sec>
</div>
</front>
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Movement Disorders (revue)

Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women

Alcohol and Risk of Parkinson Disease in a Large Prospective Cohort of Men and Women

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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