Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Identifieur interne : 000E96 ( Main/Merge ); précédent : 000E95; suivant : 000E97Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Auteurs : Lonneke M L. De Lau [Pays-Bas] ; Dagmar Verbaan ; Johan Marinus ; Peter Heutink ; Jacobus J. Van HiltenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Antiparasitic Agents (adverse effects), Catechol O-Methyltransferase (genetics), Cohort Studies, Dyskinesia, Drug-Induced (genetics), Dyskinesias (genetics), Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Methionine (genetics), Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Polymorphism, Genetic (genetics), Proportional Hazards Models, Valine (genetics).
- MESH :
- chemical , adverse effects : Antiparasitic Agents.
- chemical , genetics : Catechol O-Methyltransferase, Methionine, Valine.
- drug therapy : Parkinson Disease.
- genetics : Dyskinesia, Drug-Induced, Dyskinesias, Parkinson Disease, Polymorphism, Genetic.
- Aged, Cohort Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Proportional Hazards Models.
Abstract
The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.
DOI: 10.1002/mds.23805
PubMed: 22083803
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pubmed:22083803Le document en format XML
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<author><name sortKey="De Lau, Lonneke M L" sort="De Lau, Lonneke M L" uniqKey="De Lau L" first="Lonneke M L" last="De Lau">Lonneke M L. De Lau</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. l.delau@erasmusmc.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name>
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<author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name>
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<author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name>
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<author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name>
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<author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name>
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<author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name>
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<author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<imprint><date when="2012" type="published">2012</date>
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<term>Antiparasitic Agents (adverse effects)</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>Cohort Studies</term>
<term>Dyskinesia, Drug-Induced (genetics)</term>
<term>Dyskinesias (genetics)</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Methionine (genetics)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Proportional Hazards Models</term>
<term>Valine (genetics)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparasitic Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term>
<term>Methionine</term>
<term>Valine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Dyskinesias</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
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<front><div type="abstract" xml:lang="en">The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.</div>
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