Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Identifieur interne : 003465 ( Ncbi/Merge ); précédent : 003464; suivant : 003466Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Auteurs : Lonneke M L. De Lau [Pays-Bas] ; Dagmar Verbaan ; Johan Marinus ; Peter Heutink ; Jacobus J. Van HiltenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Antiparasitic Agents (adverse effects), Catechol O-Methyltransferase (genetics), Cohort Studies, Dyskinesia, Drug-Induced (genetics), Dyskinesias (genetics), Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Methionine (genetics), Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (genetics), Polymorphism, Genetic (genetics), Proportional Hazards Models, Valine (genetics).
- MESH :
- chemical , adverse effects : Antiparasitic Agents.
- chemical , genetics : Catechol O-Methyltransferase, Methionine, Valine.
- drug therapy : Parkinson Disease.
- genetics : Dyskinesia, Drug-Induced, Dyskinesias, Parkinson Disease, Polymorphism, Genetic.
- Aged, Cohort Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Proportional Hazards Models.
Abstract
The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.
DOI: 10.1002/mds.23805
PubMed: 22083803
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De Lau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. l.delau@erasmusmc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></author><author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.23805</idno><idno type="RBID">pubmed:22083803</idno><idno type="pmid">22083803</idno><idno type="wicri:Area/PubMed/Corpus">000F65</idno><idno type="wicri:Area/PubMed/Curation">000F65</idno><idno type="wicri:Area/PubMed/Checkpoint">000F04</idno><idno type="wicri:Area/Ncbi/Merge">003465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.</title><author><name sortKey="De Lau, Lonneke M L" sort="De Lau, Lonneke M L" uniqKey="De Lau L" first="Lonneke M L" last="De Lau">Lonneke M L. De Lau</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. l.delau@erasmusmc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></author><author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparasitic Agents (adverse effects)</term><term>Catechol O-Methyltransferase (genetics)</term><term>Cohort Studies</term><term>Dyskinesia, Drug-Induced (genetics)</term><term>Dyskinesias (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Methionine (genetics)</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic (genetics)</term><term>Proportional Hazards Models</term><term>Valine (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparasitic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term><term>Methionine</term><term>Valine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Dyskinesias</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22083803</PMID><DateCreated><Year>2012</Year><Month>01</Month><Day>18</Day></DateCreated><DateCompleted><Year>2012</Year><Month>05</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>132-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23805</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD.</AbstractText><CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Lau</LastName><ForeName>Lonneke M L</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. l.delau@erasmusmc.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verbaan</LastName><ForeName>Dagmar</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Marinus</LastName><ForeName>Johan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Heutink</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>van 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Van Hilten</name><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Lau, Lonneke M L" sort="De Lau, Lonneke M L" uniqKey="De Lau L" first="Lonneke M L" last="De Lau">Lonneke M L. De Lau</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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