Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging
Identifieur interne : 000C65 ( Main/Merge ); précédent : 000C64; suivant : 000C66Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging
Auteurs : Elizabeth A. Coon [États-Unis] ; Jennifer L. Whitwell [États-Unis] ; Clifford R. Jack [États-Unis] ; Keith A. Josephs [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Anisotropy, Case-Control Studies, Corpus Callosum (pathology), Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, Motor Neuron Disease (diagnosis), Prospective Studies, Pyramidal Tracts (pathology), Supranuclear Palsy, Progressive (physiopathology), Tegmentum Mesencephali (pathology).
- MESH :
- diagnosis : Motor Neuron Disease.
- pathology : Corpus Callosum, Pyramidal Tracts, Tegmentum Mesencephali.
- physiopathology : Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Anisotropy, Case-Control Studies, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.
Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncle and body of the corpus callosum between groups.
Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncles and body of the corpus callosum compared to controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (p<0.02).
The corticospinal tract/superior cerebellar peduncle ratio is a marker to differentiate primary lateral sclerosis from progressive supranuclear palsy.
Url:
DOI: 10.1002/mds.24990
PubMed: 22517038
PubMed Central: 3383380
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PMC:3383380Le document en format XML
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<author><name sortKey="Coon, Elizabeth A" sort="Coon, Elizabeth A" uniqKey="Coon E" first="Elizabeth A." last="Coon">Elizabeth A. Coon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
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<wicri:cityArea>Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<wicri:cityArea>Department of Radiology, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name>
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<wicri:cityArea>Department of Radiology, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Primary Lateral Sclerosis as Progressive Supranuclear Palsy: Diagnosis by Diffusion Tensor Imaging</title>
<author><name sortKey="Coon, Elizabeth A" sort="Coon, Elizabeth A" uniqKey="Coon E" first="Elizabeth A." last="Coon">Elizabeth A. Coon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
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<wicri:cityArea>Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer L." last="Whitwell">Jennifer L. Whitwell</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Department of Radiology, Mayo Clinic, Rochester</wicri:cityArea>
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</author>
<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mayo Clinic, Rochester, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
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<wicri:cityArea>Department of Radiology, Mayo Clinic, Rochester</wicri:cityArea>
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<author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith A." last="Josephs">Keith A. Josephs</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
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<wicri:cityArea>Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
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<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
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<imprint><date when="2012">2012</date>
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<term>Aged, 80 and over</term>
<term>Anisotropy</term>
<term>Case-Control Studies</term>
<term>Corpus Callosum (pathology)</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Neuron Disease (diagnosis)</term>
<term>Prospective Studies</term>
<term>Pyramidal Tracts (pathology)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Tegmentum Mesencephali (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Motor Neuron Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Callosum</term>
<term>Pyramidal Tracts</term>
<term>Tegmentum Mesencephali</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Anisotropy</term>
<term>Case-Control Studies</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncle and body of the corpus callosum between groups.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncles and body of the corpus callosum compared to controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (p<0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The corticospinal tract/superior cerebellar peduncle ratio is a marker to differentiate primary lateral sclerosis from progressive supranuclear palsy.</p>
</sec>
</div>
</front>
</TEI>
</record>
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