Movement Disorders (revue)

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Primary lateral sclerosis as progressive supranuclear palsy: diagnosis by diffusion tensor imaging.

Identifieur interne : 000C75 ( PubMed/Checkpoint ); précédent : 000C74; suivant : 000C76

Primary lateral sclerosis as progressive supranuclear palsy: diagnosis by diffusion tensor imaging.

Auteurs : Elizabeth A. Coon [États-Unis] ; Jennifer L. Whitwell ; Clifford R. Jack ; Keith A. Josephs

Source :

RBID : pubmed:22517038

English descriptors

Abstract

Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.

DOI: 10.1002/mds.24990
PubMed: 22517038


Affiliations:


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pubmed:22517038

Le document en format XML

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<div type="abstract" xml:lang="en">Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.</div>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncles, and body of the corpus callosum between groups.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncle and body of the corpus callosum compared with controls, but only primary lateral sclerosis subjects showed reductions in the corticospinal tracts. A ratio of corticospinal tract/superior cerebellar peduncle best distinguished the disorders (P < .02).</AbstractText>
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