MovDisordV3, Main, Merge, bibRecord, 000606

Determinants of Functional Disability in Huntington’s Disease: Role of Cognitive and Motor Dysfunction

Identifieur interne : 000606 ( Main/Merge ); précédent : 000605; suivant : 000607

Determinants of Functional Disability in Huntington’s Disease: Role of Cognitive and Motor Dysfunction

Auteurs : Christopher A. Ross ; Alex Pantelyat ; Jane Kogan ; Jason Brandt

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4197404

English descriptors

KwdEn :
- Activities of Daily Living, Cognition Disorders (etiology), Disabled Persons, Humans, Huntington Disease (complications), Movement Disorders (etiology), Neuropsychological Tests, Severity of Illness Index.
MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Movement Disorders.
- Activities of Daily Living, Disabled Persons, Humans, Neuropsychological Tests, Severity of Illness Index.

Abstract

The clinical syndrome of Huntington’s disease is notable for a triad of motor, cognitive and emotional features. All HD patients eventually become occupationally disabled; however the factors that render HD patients unable to maintain employment have not been extensively studied. This review begins by discussing the clinical triad of HD, highlighting the distinction in the motor disorder between involuntary movements such as chorea, and voluntary movement impairment, with the latter contributing more to functional disability. Cognitive disorder clearly contributes to disability, though the relative contribution compared to motor is difficult to unravel, especially since many of the tests used to asses “cognition” have a strong motor component. The role of emotional changes in disability needs more study. The literature on contributions to functional disability, driving impairment and nursing home placement is reviewed. Relevant experience is presented from the longstanding JHU HD observational study on motor vs cognitive onset, and on cognitive and motor features at the time when individuals discontinued working. Finally, we briefly review government policies in several countries on disability determination. We interpret the data from our own studies and from the literature to indicate that there is usually a close relationship between cognitive and motor dysfunction, and that it is critical to take both into consideration in determining disability.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197404

DOI: 10.1002/mds.26012
PubMed: 25216368
PubMed Central: 4197404

Links to Exploration step

PMC:4197404

Le document en format XML

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<author><name sortKey="Kogan, Jane" sort="Kogan, Jane" uniqKey="Kogan J" first="Jane" last="Kogan">Jane Kogan</name>
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<affiliation><nlm:aff id="A1">Division of Neurobiology, Department of Psychiatry, Departments of Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P1">The clinical syndrome of Huntington’s disease is notable for a triad of motor, cognitive and emotional features. All HD patients eventually become occupationally disabled; however the factors that render HD patients unable to maintain employment have not been extensively studied. This review begins by discussing the clinical triad of HD, highlighting the distinction in the motor disorder between involuntary movements such as chorea, and voluntary movement impairment, with the latter contributing more to functional disability. Cognitive disorder clearly contributes to disability, though the relative contribution compared to motor is difficult to unravel, especially since many of the tests used to asses “cognition” have a strong motor component. The role of emotional changes in disability needs more study. The literature on contributions to functional disability, driving impairment and nursing home placement is reviewed. Relevant experience is presented from the longstanding JHU HD observational study on motor vs cognitive onset, and on cognitive and motor features at the time when individuals discontinued working. Finally, we briefly review government policies in several countries on disability determination. We interpret the data from our own studies and from the literature to indicate that there is usually a close relationship between cognitive and motor dysfunction, and that it is critical to take both into consideration in determining disability.</p>
</div>
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Movement Disorders (revue)

Determinants of Functional Disability in Huntington’s Disease: Role of Cognitive and Motor Dysfunction

Determinants of Functional Disability in Huntington’s Disease: Role of Cognitive and Motor Dysfunction

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.