Development of a prediction formula of Parkinson disease severity by optical coherence tomography.
Identifieur interne : 000605 ( Main/Merge ); précédent : 000604; suivant : 000606Development of a prediction formula of Parkinson disease severity by optical coherence tomography.
Auteurs : Beatriz Jiménez [Espagne] ; Francisco J. Ascaso ; José A. Crist Bal ; Javier L Pez Del ValSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- pathology : Nerve Fibers, Parkinson Disease, Retina.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Tomography, Optical Coherence.
Abstract
The aims of this study were to assess the peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease (PD), to determine its correlation with disease severity, and to define a simple biomarker for predicting clinical severity. One hundred two eyes from 52 patients affected by PD were compared with 97 eyes from 50 age-comparable controls. In all patients, peripapillary RNFL thickness was measured by optical coherence tomography (OCT). We used the Unified Parkinson's Disease Rating Scale (UPDRS) total score and measured responses in the on medication state. Eyes from patients with PD had a statistically significant decrease in average peripapillary RNFL thickness compared with control eyes (P < 0.001). This reduction was observed in every quadrant (inferior, superior, nasal [P < 0.001], and temporal [P = 0.017]) in patients with PD. Furthermore, a strong inverse correlation was found between the PD severity measured according to the UPDRS score and the average peripapillary RNFL thickness (r = -0.615; P < 0.001) and PD duration (r = -0.303; P = 0.002). From these results, we defined a regression equation that predicts the UPDRS score from the above-mentioned variables: UPDRS = 81.6 + 29.6 * log PD duration (years) - 0.6 * RFNL thickness (μm). We observed that, as the evolution and severity of PD progress, the peripapillary RNFL layer thickness, as evaluated by OCT, gradually diminishes. These results suggest that the average peripapillary RNFL thickness measured by OCT might be useful as a biomarker to detect the early onset and progression of PD.
DOI: 10.1002/mds.25747
PubMed: 24458320
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000598
- to stream PubMed, to step Curation: 000598
- to stream PubMed, to step Checkpoint: 000620
- to stream Ncbi, to step Merge: 003E99
- to stream Ncbi, to step Curation: 003E99
- to stream Ncbi, to step Checkpoint: 003E99
Links to Exploration step
pubmed:24458320Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of a prediction formula of Parkinson disease severity by optical coherence tomography.</title>
<author><name sortKey="Jimenez, Beatriz" sort="Jimenez, Beatriz" uniqKey="Jimenez B" first="Beatriz" last="Jiménez">Beatriz Jiménez</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital, Zaragoza, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital, Zaragoza</wicri:regionArea>
<wicri:noRegion>Zaragoza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ascaso, Francisco J" sort="Ascaso, Francisco J" uniqKey="Ascaso F" first="Francisco J" last="Ascaso">Francisco J. Ascaso</name>
</author>
<author><name sortKey="Crist Bal, Jose A" sort="Crist Bal, Jose A" uniqKey="Crist Bal J" first="José A" last="Crist Bal">José A. Crist Bal</name>
</author>
<author><name sortKey="L Pez Del Val, Javier" sort="L Pez Del Val, Javier" uniqKey="L Pez Del Val J" first="Javier" last="L Pez Del Val">Javier L Pez Del Val</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="doi">10.1002/mds.25747</idno>
<idno type="RBID">pubmed:24458320</idno>
<idno type="pmid">24458320</idno>
<idno type="wicri:Area/PubMed/Corpus">000598</idno>
<idno type="wicri:Area/PubMed/Curation">000598</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000620</idno>
<idno type="wicri:Area/Ncbi/Merge">003E99</idno>
<idno type="wicri:Area/Ncbi/Curation">003E99</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003E99</idno>
<idno type="wicri:Area/Main/Merge">000605</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Development of a prediction formula of Parkinson disease severity by optical coherence tomography.</title>
<author><name sortKey="Jimenez, Beatriz" sort="Jimenez, Beatriz" uniqKey="Jimenez B" first="Beatriz" last="Jiménez">Beatriz Jiménez</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital, Zaragoza, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital, Zaragoza</wicri:regionArea>
<wicri:noRegion>Zaragoza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ascaso, Francisco J" sort="Ascaso, Francisco J" uniqKey="Ascaso F" first="Francisco J" last="Ascaso">Francisco J. Ascaso</name>
</author>
<author><name sortKey="Crist Bal, Jose A" sort="Crist Bal, Jose A" uniqKey="Crist Bal J" first="José A" last="Crist Bal">José A. Crist Bal</name>
</author>
<author><name sortKey="L Pez Del Val, Javier" sort="L Pez Del Val, Javier" uniqKey="L Pez Del Val J" first="Javier" last="L Pez Del Val">Javier L Pez Del Val</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nerve Fibers (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (pathology)</term>
<term>Predictive Value of Tests</term>
<term>Retina (pathology)</term>
<term>Tomography, Optical Coherence</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nerve Fibers</term>
<term>Parkinson Disease</term>
<term>Retina</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Tomography, Optical Coherence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aims of this study were to assess the peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease (PD), to determine its correlation with disease severity, and to define a simple biomarker for predicting clinical severity. One hundred two eyes from 52 patients affected by PD were compared with 97 eyes from 50 age-comparable controls. In all patients, peripapillary RNFL thickness was measured by optical coherence tomography (OCT). We used the Unified Parkinson's Disease Rating Scale (UPDRS) total score and measured responses in the on medication state. Eyes from patients with PD had a statistically significant decrease in average peripapillary RNFL thickness compared with control eyes (P < 0.001). This reduction was observed in every quadrant (inferior, superior, nasal [P < 0.001], and temporal [P = 0.017]) in patients with PD. Furthermore, a strong inverse correlation was found between the PD severity measured according to the UPDRS score and the average peripapillary RNFL thickness (r = -0.615; P < 0.001) and PD duration (r = -0.303; P = 0.002). From these results, we defined a regression equation that predicts the UPDRS score from the above-mentioned variables: UPDRS = 81.6 + 29.6 * log PD duration (years) - 0.6 * RFNL thickness (μm). We observed that, as the evolution and severity of PD progress, the peripapillary RNFL layer thickness, as evaluated by OCT, gradually diminishes. These results suggest that the average peripapillary RNFL thickness measured by OCT might be useful as a biomarker to detect the early onset and progression of PD.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000605 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000605 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= pubmed:24458320 |texte= Development of a prediction formula of Parkinson disease severity by optical coherence tomography. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:24458320" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |