Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.
Identifieur interne : 000259 ( Main/Merge ); précédent : 000258; suivant : 000260Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.
Auteurs : I. Ruiz-Dediego [Espagne] ; J R Naranjo [Espagne] ; D. Hervé [Espagne] ; R. Moratalla [Espagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.
DOI: 10.1002/mds.26197
PubMed: 25772224
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<front><div type="abstract" xml:lang="en">In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.</div>
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