Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.
Identifieur interne : 004289 ( Ncbi/Merge ); précédent : 004288; suivant : 004290Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.
Auteurs : I. Ruiz-Dediego [Espagne] ; J R Naranjo [Espagne] ; D. Hervé [Espagne] ; R. Moratalla [Espagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.
DOI: 10.1002/mds.26197
PubMed: 25772224
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Ruiz-Dediego</name><affiliation wicri:level="3"><nlm:affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Naranjo, J R" sort="Naranjo, J R" uniqKey="Naranjo J" first="J R" last="Naranjo">J R Naranjo</name><affiliation wicri:level="3"><nlm:affiliation>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Herve, D" sort="Herve, D" uniqKey="Herve D" first="D" last="Hervé">D. Hervé</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR S-839, CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Inserm UMR S-839, CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Moratalla, R" sort="Moratalla, R" uniqKey="Moratalla R" first="R" last="Moratalla">R. Moratalla</name><affiliation wicri:level="3"><nlm:affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25772224</idno><idno type="pmid">25772224</idno><idno type="doi">10.1002/mds.26197</idno><idno type="wicri:Area/PubMed/Corpus">000229</idno><idno type="wicri:Area/PubMed/Curation">000229</idno><idno type="wicri:Area/PubMed/Checkpoint">000260</idno><idno type="wicri:Area/Ncbi/Merge">004289</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.</title><author><name sortKey="Ruiz Dediego, I" sort="Ruiz Dediego, I" uniqKey="Ruiz Dediego I" first="I" last="Ruiz-Dediego">I. Ruiz-Dediego</name><affiliation wicri:level="3"><nlm:affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Naranjo, J R" sort="Naranjo, J R" uniqKey="Naranjo J" first="J R" last="Naranjo">J R Naranjo</name><affiliation wicri:level="3"><nlm:affiliation>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Herve, D" sort="Herve, D" uniqKey="Herve D" first="D" last="Hervé">D. Hervé</name><affiliation wicri:level="3"><nlm:affiliation>Inserm UMR S-839, CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Inserm UMR S-839, CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Moratalla, R" sort="Moratalla, R" uniqKey="Moratalla R" first="R" last="Moratalla">R. Moratalla</name><affiliation wicri:level="3"><nlm:affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">25772224</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>16</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Dopaminergic regulation of olfactory type G-protein α subunit expression in the striatum.</ArticleTitle><Pagination><MedlinePgn>1039-49</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26197</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In rodents, the olfactory type G-protein α subunit (Gαolf) couples the dopamine D1 receptor (D1R) to adenylyl cyclase, triggering intracellular signaling and neuronal activation. In the striatum, Gαolf is enriched in the striosomes. Changes in Gαolf protein levels have been observed after dopamine depletion. However, the regulation of Gαolf expression by dopamine and dopamine receptors is not fully understood.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">To address this, Striatal Gαolf expression pattern was studied in wild-type and genetically engineered mice lacking D1R, D2R (D2 receptor), and downstream regulatory element antagonist modulator (DREAM) protein whose dopamine levels were manipulated. Dopamine depletion was accomplished by 6-hydroxydopamine (6-OHDA) or by Pitx3 ablation, and dopamine replacement by chronic levodopa (l-dopa). The Gαolf levels were analyzed by immunohistochemistry, Western blot, and real-time quantitative polymerase chain reaction (RT-qPCR).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Our results demostrate that Dopamine depletion or inactivation of D1R abolished the striosomal pattern of Gαolf expression and increased Gαolf protein levels. Dopamine replacement in wild-type lesioned mice reestablished both the expression pattern and protein levels, but paradoxically increased Gαolf messenger RNA (mRNA). In D1R(-/-) mice, dopamine depletion decreased striatal Gαolf expression, whereas l-dopa did not restore either Gαolf levels or its expression pattern. Inactivation of D2R or changes in the cAMP/PKA signaling pathway downstream of Gαolf did not modify its expression.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results show a homeostatic, negative regulation of Gαolf by dopamine and by D1R stimulation, which are also required for the striosomal Gαolf pattern. These results shed light on the regulation of Gαolf by dopamine signaling that could be involved in the pathophysiology of the maladaptive response to chronic l-dopa treatment in Parkinson's disease.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ruiz-DeDiego</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naranjo</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro Nacional de Biotecnología, CSIC, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hervé</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Inserm UMR S-839, CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut du Fer à Moulin, CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Pierre et Marie Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moratalla</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cajal Institute, Consejo Superior de Investigaciones Científicas (CSIC), CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBERNED, Instituto de Salud Carlos III, CIBERNED, Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AIMs</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">dopaminergic receptors</Keyword><Keyword MajorTopicYN="N">l-dopa</Keyword><Keyword MajorTopicYN="N">striosomes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>1</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>1</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>3</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25772224</ArticleId><ArticleId IdType="doi">10.1002/mds.26197</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ruiz Dediego, I" sort="Ruiz Dediego, I" uniqKey="Ruiz Dediego I" first="I" last="Ruiz-Dediego">I. Ruiz-Dediego</name></region><name sortKey="Herve, D" sort="Herve, D" uniqKey="Herve D" first="D" last="Hervé">D. Hervé</name><name sortKey="Moratalla, R" sort="Moratalla, R" uniqKey="Moratalla R" first="R" last="Moratalla">R. Moratalla</name><name sortKey="Naranjo, J R" sort="Naranjo, J R" uniqKey="Naranjo J" first="J R" last="Naranjo">J R Naranjo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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