Postencephalitic stereotyped involuntary movements responsive to L‐Dopa
Identifieur interne : 005594 ( Main/Exploration ); précédent : 005593; suivant : 005595Postencephalitic stereotyped involuntary movements responsive to L‐Dopa
Auteurs : Picard [France] ; A. De Saint-Martin [France] ; E. Salmon [Belgique] ; E. Hirsch [France] ; C. Marescaux [France]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-09.
English descriptors
- KwdEn :
- Adult, Bromocriptine (administration & dosage), Bromocriptine (therapeutic use), Dopamine Agonists (administration & dosage), Dopamine Agonists (therapeutic use), Drug Therapy, Combination, Encephalitis (complications), Encephalitis (physiopathology), Encephalitis lethargica, Humans, Hyperkinesia, Levodopa (administration & dosage), Levodopa (pharmacology), Levodopa (therapeutic use), L‐Dopa, Magnetic Resonance Imaging, Male, Parkinson Disease, Secondary (complications), Parkinson Disease, Secondary (drug therapy), Parkinsonism, Putamen (physiopathology), Receptors, Dopamine D2 (drug effects), Stereotyped Behavior, Tomography, X-Ray Computed, Trihexyphenidyl (administration & dosage), Trihexyphenidyl (therapeutic use).
- MESH :
- chemical , administration & dosage : Bromocriptine, Dopamine Agonists, Levodopa, Trihexyphenidyl.
- chemical , drug effects : Receptors, Dopamine D2.
- chemical , pharmacology : Levodopa.
- chemical , therapeutic use : Bromocriptine, Dopamine Agonists, Levodopa, Trihexyphenidyl.
- complications : Encephalitis, Parkinson Disease, Secondary.
- drug therapy : Parkinson Disease, Secondary.
- physiopathology : Encephalitis, Putamen.
- Adult, Drug Therapy, Combination, Humans, Magnetic Resonance Imaging, Male, Stereotyped Behavior, Tomography, X-Ray Computed.
Abstract
In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.
Url:
DOI: 10.1002/mds.870110513
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002A10
- to stream Istex, to step Curation: 002A10
- to stream Istex, to step Checkpoint: 003A96
- to stream PubMed, to step Corpus: 004780
- to stream PubMed, to step Curation: 004780
- to stream PubMed, to step Checkpoint: 004778
- to stream Ncbi, to step Merge: 004C02
- to stream Ncbi, to step Curation: 004C02
- to stream Ncbi, to step Checkpoint: 004C02
- to stream Main, to step Merge: 008700
- to stream Main, to step Curation: 005594
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Postencephalitic stereotyped involuntary movements responsive to L‐Dopa</title><author><name sortKey="Picard" sort="Picard" uniqKey="Picard" last="Picard">Picard</name></author><author><name sortKey="De Saint Artin, A" sort="De Saint Artin, A" uniqKey="De Saint Artin A" first="A." last="De Saint-Martin">A. De Saint-Martin</name></author><author><name sortKey="Salmon, E" sort="Salmon, E" uniqKey="Salmon E" first="E." last="Salmon">E. Salmon</name></author><author><name sortKey="Hirsch, E" sort="Hirsch, E" uniqKey="Hirsch E" first="E." last="Hirsch">E. Hirsch</name></author><author><name sortKey="Marescaux, C" sort="Marescaux, C" uniqKey="Marescaux C" first="C." last="Marescaux">C. Marescaux</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1002/mds.870110513</idno><idno type="url">https://api.istex.fr/document/2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002A10</idno><idno type="wicri:Area/Istex/Curation">002A10</idno><idno type="wicri:Area/Istex/Checkpoint">003A96</idno><idno type="wicri:doubleKey">0885-3185:1996:Picard:postencephalitic:stereotyped:involuntary</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:8866499</idno><idno type="wicri:Area/PubMed/Corpus">004780</idno><idno type="wicri:Area/PubMed/Curation">004780</idno><idno type="wicri:Area/PubMed/Checkpoint">004778</idno><idno type="wicri:Area/Ncbi/Merge">004C02</idno><idno type="wicri:Area/Ncbi/Curation">004C02</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C02</idno><idno type="wicri:doubleKey">0885-3185:1996:Picard F:postencephalitic:stereotyped:involuntary</idno><idno type="wicri:Area/Main/Merge">008700</idno><idno type="wicri:Area/Main/Curation">005594</idno><idno type="wicri:Area/Main/Exploration">005594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Postencephalitic stereotyped involuntary movements responsive to L‐Dopa</title><author><name sortKey="Picard" sort="Picard" uniqKey="Picard" last="Picard">Picard</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg</wicri:regionArea><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion></affiliation></author><author><name sortKey="De Saint Artin, A" sort="De Saint Artin, A" uniqKey="De Saint Artin A" first="A." last="De Saint-Martin">A. De Saint-Martin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg</wicri:regionArea><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion></affiliation></author><author><name sortKey="Salmon, E" sort="Salmon, E" uniqKey="Salmon E" first="E." last="Salmon">E. Salmon</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité Médicale du Cyclotron, Université de Liége, Liege</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Hirsch, E" sort="Hirsch, E" uniqKey="Hirsch E" first="E." last="Hirsch">E. Hirsch</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg</wicri:regionArea><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion></affiliation></author><author><name sortKey="Marescaux, C" sort="Marescaux, C" uniqKey="Marescaux C" first="C." last="Marescaux">C. Marescaux</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg</wicri:regionArea><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion><wicri:noRegion>Hǒpitaux Universitaires de Strasbourg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-09">1996-09</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="567">567</biblScope><biblScope unit="page" to="570">570</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB</idno><idno type="DOI">10.1002/mds.870110513</idno><idno type="ArticleID">MDS870110513</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bromocriptine (administration & dosage)</term><term>Bromocriptine (therapeutic use)</term><term>Dopamine Agonists (administration & dosage)</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Encephalitis (complications)</term><term>Encephalitis (physiopathology)</term><term>Encephalitis lethargica</term><term>Humans</term><term>Hyperkinesia</term><term>Levodopa (administration & dosage)</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>L‐Dopa</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Parkinson Disease, Secondary (complications)</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Parkinsonism</term><term>Putamen (physiopathology)</term><term>Receptors, Dopamine D2 (drug effects)</term><term>Stereotyped Behavior</term><term>Tomography, X-Ray Computed</term><term>Trihexyphenidyl (administration & dosage)</term><term>Trihexyphenidyl (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Bromocriptine</term><term>Dopamine Agonists</term><term>Levodopa</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bromocriptine</term><term>Dopamine Agonists</term><term>Levodopa</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Encephalitis</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Encephalitis</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Stereotyped Behavior</term><term>Tomography, X-Ray Computed</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="de">In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Province de Liège</li><li>Région wallonne</li></region><settlement><li>Liège</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Picard" sort="Picard" uniqKey="Picard" last="Picard">Picard</name></noRegion><name sortKey="De Saint Artin, A" sort="De Saint Artin, A" uniqKey="De Saint Artin A" first="A." last="De Saint-Martin">A. De Saint-Martin</name><name sortKey="Hirsch, E" sort="Hirsch, E" uniqKey="Hirsch E" first="E." last="Hirsch">E. Hirsch</name><name sortKey="Marescaux, C" sort="Marescaux, C" uniqKey="Marescaux C" first="C." last="Marescaux">C. Marescaux</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Salmon, E" sort="Salmon, E" uniqKey="Salmon E" first="E." last="Salmon">E. Salmon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005594 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005594 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB
|texte= Postencephalitic stereotyped involuntary movements responsive to L‐Dopa
}}
| This area was generated with Dilib version V0.6.23. |  |