Postencephalitic stereotyped involuntary movements responsive to L‐Dopa
Identifieur interne : 002A10 ( Istex/Corpus ); précédent : 002A09; suivant : 002A11Postencephalitic stereotyped involuntary movements responsive to L‐Dopa
Auteurs : Picard ; A. De Saint-Martin ; E. Salmon ; E. Hirsch ; C. MarescauxSource :
- Movement Disorders [ 0885-3185 ] ; 1996-09.
English descriptors
- KwdEn :
Abstract
In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.
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DOI: 10.1002/mds.870110513
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ISTEX:2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEBLe document en format XML
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After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dr. Picard</name><affiliations><json:string>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</json:string></affiliations></json:item><json:item><name>A. de Saint‐Martin</name><affiliations><json:string>Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</json:string></affiliations></json:item><json:item><name>E. Salmon</name><affiliations><json:string>Unité Médicale du Cyclotron, Université de Liége, Liege, Belgium</json:string></affiliations></json:item><json:item><name>E. 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These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Encephalitis lethargica</term></item><item><term>Parkinsonism</term></item><item><term>Hyperkinesia</term></item><item><term>L‐Dopa</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-01-12">Registration</change><change when="1996-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D<sup>2</sup> antagonist and was fully reproduced by a D<sup>2</sup> agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Postencephalitic stereotyped involuntary movements responsive to L‐Dopa</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DOPA‐SENSITIVE POSTENCEPHALITIC DYSKINESIA</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Postencephalitic stereotyped involuntary movements responsive to</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Picard</namePart><affiliation>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</affiliation><description>Correspondence: Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, Hǒpitaux Universitaires, 1 place de l'Hǒpital, 67091 Strasbourg Cedex, France</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">de Saint‐Martin</namePart><affiliation>Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Salmon</namePart><affiliation>Unité Médicale du Cyclotron, Université de Liége, Liege, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Hirsch</namePart><affiliation>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Marescaux</namePart><affiliation>Service de Neurologie, Neuropsychologie et Explorations Fonctionnelles des Epilepsies, and Service de Pédiatrie, Hǒpitaux Universitaires de Strasbourg, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">shortCommunication</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1996-09</dateIssued><dateValid encoding="w3cdtf">1996-01-12</dateValid><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">32</extent></physicalDescription><abstract lang="de">In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L‐Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L‐Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra.</abstract><subject lang="en"><genre>Keywords</genre><topic>Encephalitis lethargica</topic><topic>Parkinsonism</topic><topic>Hyperkinesia</topic><topic>L‐Dopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>567</start><end>570</end><total>4</total></extent></part></relatedItem><identifier type="istex">2BBFA4DB1DDB650C8F3636B263B3BF9146E63FEB</identifier><identifier type="DOI">10.1002/mds.870110513</identifier><identifier type="ArticleID">MDS870110513</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1996 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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