Histologic assessment of dose‐related diffusion and muscle fiber response after therapeutic botulinum a toxin injections
Identifieur interne : 005B67 ( Main/Exploration ); précédent : 005B66; suivant : 005B68Histologic assessment of dose‐related diffusion and muscle fiber response after therapeutic botulinum a toxin injections
Auteurs : Borodic [États-Unis] ; Robert Ferrante ; L. Bruce Pearce [États-Unis] ; Karen Smith [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Animals, Biopsy, Blepharospasm, Botulinum Toxins (pharmacokinetics), Botulinum Toxins (pharmacology), Botulinum Toxins (toxicity), Botulinum toxin, Diffusion, Dose-Response Relationship, Drug, Dystonia Meige syndrome, Hemifacial spasm, Injections, Intramuscular, Muscle Denervation, Muscle fiber, Muscles (drug effects), Muscles (innervation), Muscles (pathology), Neuromuscular Junction (drug effects), Neuromuscular Junction (pathology), Rabbits, Spasmodic dysphonia, Spasmodic torticollis.
- MESH :
- chemical , metabolism : Acetylcholinesterase.
- chemical , pharmacokinetics : Botulinum Toxins.
- chemical , pharmacology : Botulinum Toxins.
- chemical , toxicity : Botulinum Toxins.
- drug effects : Muscles, Neuromuscular Junction.
- innervation : Muscles.
- pathology : Muscles, Neuromuscular Junction.
- Animals, Biopsy, Diffusion, Dose-Response Relationship, Drug, Injections, Intramuscular, Muscle Denervation, Rabbits.
Abstract
Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15–30‐mm segment of muscle. At higher doses (5–10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.
Url:
DOI: 10.1002/mds.870090106
Affiliations:
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Bruce" last="Pearce">L. Bruce Pearce</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Smith, Karen" sort="Smith, Karen" uniqKey="Smith K" first="Karen" last="Smith">Karen Smith</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="31">31</biblScope><biblScope unit="page" to="39">39</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">944979E5571B4D53B6A23F476FC6F04DE4C09033</idno><idno type="DOI">10.1002/mds.870090106</idno><idno type="ArticleID">MDS870090106</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Animals</term><term>Biopsy</term><term>Blepharospasm</term><term>Botulinum Toxins (pharmacokinetics)</term><term>Botulinum Toxins (pharmacology)</term><term>Botulinum Toxins (toxicity)</term><term>Botulinum toxin</term><term>Diffusion</term><term>Dose-Response Relationship, Drug</term><term>Dystonia Meige syndrome</term><term>Hemifacial spasm</term><term>Injections, Intramuscular</term><term>Muscle Denervation</term><term>Muscle fiber</term><term>Muscles (drug effects)</term><term>Muscles (innervation)</term><term>Muscles (pathology)</term><term>Neuromuscular Junction (drug effects)</term><term>Neuromuscular Junction (pathology)</term><term>Rabbits</term><term>Spasmodic dysphonia</term><term>Spasmodic torticollis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscles</term><term>Neuromuscular Junction</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Muscles</term><term>Neuromuscular Junction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biopsy</term><term>Diffusion</term><term>Dose-Response Relationship, Drug</term><term>Injections, Intramuscular</term><term>Muscle Denervation</term><term>Rabbits</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15–30‐mm segment of muscle. At higher doses (5–10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Ferrante, Robert" sort="Ferrante, Robert" uniqKey="Ferrante R" first="Robert" last="Ferrante">Robert Ferrante</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Borodic" sort="Borodic" uniqKey="Borodic" last="Borodic">Borodic</name></region><name sortKey="Borodic" sort="Borodic" uniqKey="Borodic" last="Borodic">Borodic</name><name sortKey="Pearce, L Bruce" sort="Pearce, L Bruce" uniqKey="Pearce L" first="L. Bruce" last="Pearce">L. Bruce Pearce</name><name sortKey="Smith, Karen" sort="Smith, Karen" uniqKey="Smith K" first="Karen" last="Smith">Karen Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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