Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections.
Identifieur interne : 004B17 ( PubMed/Checkpoint ); précédent : 004B16; suivant : 004B18Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections.
Auteurs : G E Borodic [États-Unis] ; R. Ferrante ; L B Pearce ; K. SmithSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Animals, Biopsy, Botulinum Toxins (pharmacokinetics), Botulinum Toxins (pharmacology), Botulinum Toxins (toxicity), Diffusion, Dose-Response Relationship, Drug, Injections, Intramuscular, Muscle Denervation, Muscles (drug effects), Muscles (innervation), Muscles (pathology), Neuromuscular Junction (drug effects), Neuromuscular Junction (pathology), Rabbits.
- MESH :
- chemical , metabolism : Acetylcholinesterase.
- chemical , pharmacokinetics : Botulinum Toxins.
- chemical , pharmacology : Botulinum Toxins.
- chemical , toxicity : Botulinum Toxins.
- drug effects : Muscles, Neuromuscular Junction.
- innervation : Muscles.
- pathology : Muscles, Neuromuscular Junction.
- Animals, Biopsy, Diffusion, Dose-Response Relationship, Drug, Injections, Intramuscular, Muscle Denervation, Rabbits.
Abstract
Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15-30-mm segment of muscle. At higher doses (5-10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.
DOI: 10.1002/mds.870090106
PubMed: 8139603
Affiliations:
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Ferrante</name></author><author><name sortKey="Pearce, L B" sort="Pearce, L B" uniqKey="Pearce L" first="L B" last="Pearce">L B Pearce</name></author><author><name sortKey="Smith, K" sort="Smith, K" uniqKey="Smith K" first="K" last="Smith">K. Smith</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8139603</idno><idno type="pmid">8139603</idno><idno type="doi">10.1002/mds.870090106</idno><idno type="wicri:Area/PubMed/Corpus">004B55</idno><idno type="wicri:Area/PubMed/Curation">004B55</idno><idno type="wicri:Area/PubMed/Checkpoint">004B17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections.</title><author><name sortKey="Borodic, G E" sort="Borodic, G E" uniqKey="Borodic G" first="G E" last="Borodic">G E Borodic</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Ophthalmology, Massachusetts Eye and Ear Infirmary</wicri:orgArea></affiliation></author><author><name sortKey="Ferrante, R" sort="Ferrante, R" uniqKey="Ferrante R" first="R" last="Ferrante">R. Ferrante</name></author><author><name sortKey="Pearce, L B" sort="Pearce, L B" uniqKey="Pearce L" first="L B" last="Pearce">L B Pearce</name></author><author><name sortKey="Smith, K" sort="Smith, K" uniqKey="Smith K" first="K" last="Smith">K. Smith</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Animals</term><term>Biopsy</term><term>Botulinum Toxins (pharmacokinetics)</term><term>Botulinum Toxins (pharmacology)</term><term>Botulinum Toxins (toxicity)</term><term>Diffusion</term><term>Dose-Response Relationship, Drug</term><term>Injections, Intramuscular</term><term>Muscle Denervation</term><term>Muscles (drug effects)</term><term>Muscles (innervation)</term><term>Muscles (pathology)</term><term>Neuromuscular Junction (drug effects)</term><term>Neuromuscular Junction (pathology)</term><term>Rabbits</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Botulinum Toxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscles</term><term>Neuromuscular Junction</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Muscles</term><term>Neuromuscular Junction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biopsy</term><term>Diffusion</term><term>Dose-Response Relationship, Drug</term><term>Injections, Intramuscular</term><term>Muscle Denervation</term><term>Rabbits</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15-30-mm segment of muscle. At higher doses (5-10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8139603</PMID><DateCreated><Year>1994</Year><Month>04</Month><Day>25</Day></DateCreated><DateCompleted><Year>1994</Year><Month>04</Month><Day>25</Day></DateCompleted><DateRevised><Year>2010</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>1994</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Histologic assessment of dose-related diffusion and muscle fiber response after therapeutic botulinum A toxin injections.</ArticleTitle><Pagination><MedlinePgn>31-9</MedlinePgn></Pagination><Abstract><AbstractText>Fiber diameter variability, acetylcholinesterase staining properties, and average fiber diameter were determined 5 weeks after varying doses of botulinum A toxin were administered into albino rabbit longissimus dorsi muscle. The average fiber diameter within the muscle appeared to be a function of the dose of botulinum toxin injected. Fiber diameter variability correlated with the dose of botulinum toxin administered. Both fiber diameter variability and acetylcholinesterase spread characteristics showed a distinct diffusion gradient over a defined field within a muscle. At lower doses (1 IU), collapse of the diffusion gradient occurred over a 15-30-mm segment of muscle. At higher doses (5-10 IU), diffusion of botulinum A toxin effect occurred throughout the entire muscle with no apparent end point. This study demonstrated that botulinum A toxin produces a gradient of denervation in a given muscle and that both the magnitude of denervation and the extent of the gradient are dose dependent. Furthermore, both muscle fiber diameter variability and acetylcholinesterase staining were useful as measures of chemodenervation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Borodic</LastName><ForeName>G E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrante</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Pearce</LastName><ForeName>L B</ForeName><Initials>LB</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>K</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.1.1.7</RegistryNumber><NameOfSubstance UI="D000110">Acetylcholinesterase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.69</RegistryNumber><NameOfSubstance UI="D001905">Botulinum Toxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000110">Acetylcholinesterase</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001706">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001905">Botulinum Toxins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000633">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004058">Diffusion</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004305">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007273">Injections, Intramuscular</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009121">Muscle Denervation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009132">Muscles</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009469">Neuromuscular Junction</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011817">Rabbits</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8139603</ArticleId><ArticleId IdType="doi">10.1002/mds.870090106</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Boston</li></settlement></list><tree><noCountry><name sortKey="Ferrante, R" sort="Ferrante, R" uniqKey="Ferrante R" first="R" last="Ferrante">R. Ferrante</name><name sortKey="Pearce, L B" sort="Pearce, L B" uniqKey="Pearce L" first="L B" last="Pearce">L B Pearce</name><name sortKey="Smith, K" sort="Smith, K" uniqKey="Smith K" first="K" last="Smith">K. Smith</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Borodic, G E" sort="Borodic, G E" uniqKey="Borodic G" first="G E" last="Borodic">G E Borodic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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