Idiopathic REM sleep behavior disorder in the transition to degenerative disease
Identifieur interne : 002264 ( Main/Exploration ); précédent : 002263; suivant : 002265Idiopathic REM sleep behavior disorder in the transition to degenerative disease
Auteurs : Ronald B. Postuma [Canada] ; Jean-Francois Gagnon [Canada] ; Melanie Vendette [Canada] ; Jacques Y. Montplaisir [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (diagnosis), Alzheimer Disease (etiology), Alzheimer disease, Alzheimer's disease, Autonomic Nervous System (physiopathology), Behavior, Cohort Studies, Degenerative disease, Depression (diagnosis), Depression (etiology), Disease Progression, Female, Humans, Idiopathic, Lewy Body Disease (diagnosis), Lewy Body Disease (etiology), Lewy body dementia, Male, Mental Status Schedule, Motor Activity (physiology), Nervous system diseases, Neurodegenerative Diseases (diagnosis), Neurodegenerative Diseases (etiology), Neuropsychological Tests, Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, REM Sleep Behavior Disorder (complications), REM sleep behavior disorder, Rapid eye movement sleep, Retrospective Studies, Sensation Disorders (diagnosis), Sensation Disorders (etiology), Sleep disorder, Transition.
- MESH :
- complications : REM Sleep Behavior Disorder.
- diagnosis : Alzheimer Disease, Depression, Lewy Body Disease, Neurodegenerative Diseases, Sensation Disorders.
- etiology : Alzheimer Disease, Depression, Lewy Body Disease, Neurodegenerative Diseases, Sensation Disorders.
- physiology : Motor Activity.
- physiopathology : Autonomic Nervous System, Parkinson Disease.
- Aged, Cohort Studies, Disease Progression, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Retrospective Studies.
Abstract
Idiopathic REM sleep behavior disorder (RBD) predicts Parkinson's disease (PD) and dementia. However, the nature of the disease that emerges from RBD has not been fully characterized. Since 2004, we have been conducting a prospective study of idiopathic RBD patients, providing an opportunity to directly observe patients as they transitioned to a defined neurodegenerative syndrome. Patients with idiopathic RBD underwent an extensive annual evaluation of motor function, olfaction, color vision, autonomic function, cognition and psychiatric symptoms. Neurodegenerative disease was defined according to standard criteria. We compared these measures in patients who had developed PD to those with dementia, all within the first year of developing disease. Of 67 patients, 6 developed PD and eleven developed dementia. Except for cognitive functioning, all tests of olfaction, color vision, autonomic function, depression, and quantitative measures of motor speed were similar in patients with PD and dementia. Of dementia patients, seven met criteria for probable Lewy body dementia (LBD) and four for Alzheimer's disease (or, possible LBD). In all probable LBD cases, the diagnosis was made because of parkinsonism, with no patient experiencing hallucinations or fluctuations. Patients with “Alzheimer's disease” seemed to have LBD, as they demonstrated typical LBD cognitive profiles on neuropsychological testing and were indistinguishable from LBD patients in ancillary measures. Therefore, among RBD patients with new‐onset LBD, hallucinations or fluctuations are absent, suggesting that RBD is a reliable early sign of LBD. The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary “RBD‐then‐neurodegeneration” process, the clinical presentation of which depends upon selective neuronal vulnerability. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22757
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000887
- to stream Istex, to step Curation: 000887
- to stream Istex, to step Checkpoint: 000E66
- to stream PubMed, to step Corpus: 001B53
- to stream PubMed, to step Curation: 001B53
- to stream PubMed, to step Checkpoint: 001D70
- to stream Ncbi, to step Merge: 002827
- to stream Ncbi, to step Curation: 002827
- to stream Ncbi, to step Checkpoint: 002827
- to stream Main, to step Merge: 002B25
- to stream PascalFrancis, to step Corpus: 000D16
- to stream PascalFrancis, to step Curation: 002003
- to stream PascalFrancis, to step Checkpoint: 000E44
- to stream Main, to step Merge: 002F41
- to stream Main, to step Curation: 002264
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Idiopathic REM sleep behavior disorder in the transition to degenerative disease</title>
<author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
</author>
<author><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Melanie" last="Vendette">Melanie Vendette</name>
</author>
<author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y." last="Montplaisir">Jacques Y. Montplaisir</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:82270E97439490C72F12E9A83AF8348090846B9E</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1002/mds.22757</idno>
<idno type="url">https://api.istex.fr/document/82270E97439490C72F12E9A83AF8348090846B9E/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000887</idno>
<idno type="wicri:Area/Istex/Curation">000887</idno>
<idno type="wicri:Area/Istex/Checkpoint">000E66</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Postuma R:idiopathic:rem:sleep</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19768814</idno>
<idno type="wicri:Area/PubMed/Corpus">001B53</idno>
<idno type="wicri:Area/PubMed/Curation">001B53</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D70</idno>
<idno type="wicri:Area/Ncbi/Merge">002827</idno>
<idno type="wicri:Area/Ncbi/Curation">002827</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002827</idno>
<idno type="wicri:Area/Main/Merge">002B25</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0036261</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000D16</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002003</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E44</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Postuma R:idiopathic:rem:sleep</idno>
<idno type="wicri:Area/Main/Merge">002F41</idno>
<idno type="wicri:Area/Main/Curation">002264</idno>
<idno type="wicri:Area/Main/Exploration">002264</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Idiopathic REM sleep behavior disorder in the transition to degenerative disease</title>
<author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre d'etude du sommeil, Hopital du Sacre‐Coeur, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre d'etude du sommeil, Hopital du Sacre‐Coeur, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Université de Montréal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Melanie" last="Vendette">Melanie Vendette</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre d'etude du sommeil, Hopital du Sacre‐Coeur, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y." last="Montplaisir">Jacques Y. Montplaisir</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre d'etude du sommeil, Hopital du Sacre‐Coeur, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Université de Montréal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-11-15">2009-11-15</date>
<biblScope unit="vol">24</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2225">2225</biblScope>
<biblScope unit="page" to="2232">2232</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">82270E97439490C72F12E9A83AF8348090846B9E</idno>
<idno type="DOI">10.1002/mds.22757</idno>
<idno type="ArticleID">MDS22757</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alzheimer Disease (diagnosis)</term>
<term>Alzheimer Disease (etiology)</term>
<term>Alzheimer disease</term>
<term>Alzheimer's disease</term>
<term>Autonomic Nervous System (physiopathology)</term>
<term>Behavior</term>
<term>Cohort Studies</term>
<term>Degenerative disease</term>
<term>Depression (diagnosis)</term>
<term>Depression (etiology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Idiopathic</term>
<term>Lewy Body Disease (diagnosis)</term>
<term>Lewy Body Disease (etiology)</term>
<term>Lewy body dementia</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Motor Activity (physiology)</term>
<term>Nervous system diseases</term>
<term>Neurodegenerative Diseases (diagnosis)</term>
<term>Neurodegenerative Diseases (etiology)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM sleep behavior disorder</term>
<term>Rapid eye movement sleep</term>
<term>Retrospective Studies</term>
<term>Sensation Disorders (diagnosis)</term>
<term>Sensation Disorders (etiology)</term>
<term>Sleep disorder</term>
<term>Transition</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term>
<term>Depression</term>
<term>Lewy Body Disease</term>
<term>Neurodegenerative Diseases</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Depression</term>
<term>Lewy Body Disease</term>
<term>Neurodegenerative Diseases</term>
<term>Sensation Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule</term>
<term>Neuropsychological Tests</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Démence d'Alzheimer</term>
<term>Démence à corps de Lewy</term>
<term>Idiopathique</term>
<term>Maladie de Parkinson</term>
<term>Maladie dégénérative</term>
<term>Pathologie du système nerveux</term>
<term>Sommeil paradoxal</term>
<term>Transition</term>
<term>Trouble du sommeil</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Idiopathic REM sleep behavior disorder (RBD) predicts Parkinson's disease (PD) and dementia. However, the nature of the disease that emerges from RBD has not been fully characterized. Since 2004, we have been conducting a prospective study of idiopathic RBD patients, providing an opportunity to directly observe patients as they transitioned to a defined neurodegenerative syndrome. Patients with idiopathic RBD underwent an extensive annual evaluation of motor function, olfaction, color vision, autonomic function, cognition and psychiatric symptoms. Neurodegenerative disease was defined according to standard criteria. We compared these measures in patients who had developed PD to those with dementia, all within the first year of developing disease. Of 67 patients, 6 developed PD and eleven developed dementia. Except for cognitive functioning, all tests of olfaction, color vision, autonomic function, depression, and quantitative measures of motor speed were similar in patients with PD and dementia. Of dementia patients, seven met criteria for probable Lewy body dementia (LBD) and four for Alzheimer's disease (or, possible LBD). In all probable LBD cases, the diagnosis was made because of parkinsonism, with no patient experiencing hallucinations or fluctuations. Patients with “Alzheimer's disease” seemed to have LBD, as they demonstrated typical LBD cognitive profiles on neuropsychological testing and were indistinguishable from LBD patients in ancillary measures. Therefore, among RBD patients with new‐onset LBD, hallucinations or fluctuations are absent, suggesting that RBD is a reliable early sign of LBD. The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary “RBD‐then‐neurodegeneration” process, the clinical presentation of which depends upon selective neuronal vulnerability. © 2009 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Québec</li>
</region>
<settlement><li>Montréal</li>
</settlement>
<orgName><li>Université McGill</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
</region>
<name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
<name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-Francois" last="Gagnon">Jean-Francois Gagnon</name>
<name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y." last="Montplaisir">Jacques Y. Montplaisir</name>
<name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y." last="Montplaisir">Jacques Y. Montplaisir</name>
<name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name>
<name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Melanie" last="Vendette">Melanie Vendette</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002264 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002264 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:82270E97439490C72F12E9A83AF8348090846B9E |texte= Idiopathic REM sleep behavior disorder in the transition to degenerative disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |