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Idiopathic REM Sleep Behavior Disorder in the Transition to Degenerative Disease

Identifieur interne : 002F41 ( Main/Merge ); précédent : 002F40; suivant : 002F42

Idiopathic REM Sleep Behavior Disorder in the Transition to Degenerative Disease

Auteurs : Ronald B. Postuma [Canada] ; Jean-Francois Gagnon [Canada] ; Melanie Vendette [Canada] ; Jacques Y. Montplaisir [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:10-0036261

Descripteurs français

Pascal (Inist)
- Trouble du sommeil, Maladie de Parkinson, Démence d'Alzheimer, Pathologie du système nerveux, Idiopathique, Sommeil paradoxal, Comportement, Transition, Maladie dégénérative, Démence à corps de Lewy.

English descriptors

KwdEn :
- Alzheimer disease, Behavior, Degenerative disease, Idiopathic, Lewy body dementia, Nervous system diseases, Parkinson disease, Rapid eye movement sleep, Sleep disorder, Transition.

Abstract

Idiopathic REM sleep behavior disorder (RBD) predicts Parkinson's disease (PD) and dementia. However, the nature of the disease that emerges from RBD has not been fully characterized. Since 2004, we have been conducting a prospective study of idiopathic RBD patients, providing an opportunity to directly observe patients as they transitioned to a defined neurodegenerative syndrome. Patients with idiopathic RBD underwent an extensive annual evaluation of motor function, olfaction, color vision, autonomic function, cognition and psychiatric symptoms. Neurodegenerative disease was defined according to standard criteria. We compared these measures in patients who had developed PD to those with dementia, all within the first year of developing disease. Of 67 patients, 6 developed PD and eleven developed dementia. Except for cognitive functioning, all tests of olfaction, color vision, autonomic function, depression, and quantitative measures of motor speed were similar in patients with PD and dementia. Of dementia patients, seven met criteria for probable Lewy body dementia (LBD) and four for Alzheimer's disease (or, possible LBD). In all probable LBD cases, the diagnosis was made because of parkinsonism, with no patient experiencing hallucinations or fluctuations. Patients with "Alzheimer's disease" seemed to have LBD, as they demonstrated typical LBD cognitive profiles on neuropsychological testing and were indistinguishable from LBD patients in ancillary measures. Therefore, among RBD patients with new-onset LBD, hallucinations or fluctuations are absent, suggesting that RBD is a reliable early sign of LBD. The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary "RBD-then-neurodegeneration" process, the clinical presentation of which depends upon selective neuronal vulnerability.

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Pascal:10-0036261

Le document en format XML

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<term>Maladie de Parkinson</term>
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<front><div type="abstract" xml:lang="en">Idiopathic REM sleep behavior disorder (RBD) predicts Parkinson's disease (PD) and dementia. However, the nature of the disease that emerges from RBD has not been fully characterized. Since 2004, we have been conducting a prospective study of idiopathic RBD patients, providing an opportunity to directly observe patients as they transitioned to a defined neurodegenerative syndrome. Patients with idiopathic RBD underwent an extensive annual evaluation of motor function, olfaction, color vision, autonomic function, cognition and psychiatric symptoms. Neurodegenerative disease was defined according to standard criteria. We compared these measures in patients who had developed PD to those with dementia, all within the first year of developing disease. Of 67 patients, 6 developed PD and eleven developed dementia. Except for cognitive functioning, all tests of olfaction, color vision, autonomic function, depression, and quantitative measures of motor speed were similar in patients with PD and dementia. Of dementia patients, seven met criteria for probable Lewy body dementia (LBD) and four for Alzheimer's disease (or, possible LBD). In all probable LBD cases, the diagnosis was made because of parkinsonism, with no patient experiencing hallucinations or fluctuations. Patients with "Alzheimer's disease" seemed to have LBD, as they demonstrated typical LBD cognitive profiles on neuropsychological testing and were indistinguishable from LBD patients in ancillary measures. Therefore, among RBD patients with new-onset LBD, hallucinations or fluctuations are absent, suggesting that RBD is a reliable early sign of LBD. The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary "RBD-then-neurodegeneration" process, the clinical presentation of which depends upon selective neuronal vulnerability.</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Idiopathic REM Sleep Behavior Disorder in the Transition to Degenerative Disease

Idiopathic REM Sleep Behavior Disorder in the Transition to Degenerative Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri