Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
Identifieur interne : 003442 ( Main/Exploration ); précédent : 003441; suivant : 003443Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
Auteurs : Karen Stergaard [Danemark] ; Niels Aa. Sunde [Danemark]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Aged, Analysis of Variance, Antiparkinson Agents (therapeutic use), Body Weight (physiology), Body Weight (radiation effects), Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Deep brain stimulation, Disease Progression, Dyskinesias (etiology), Evolution, Female, Follow-Up Studies, Humans, Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (drug effects), Motor Activity (physiology), Motor Skills (drug effects), Motor Skills (radiation effects), Nervous system diseases, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Severity of Illness Index, Subthalamic Nucleus (radiation effects), Subthalamic nucleus, Treatment Outcome, deep brain stimulation, disease evolution, subthalamic nucleus.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- adverse effects : Deep Brain Stimulation.
- drug effects : Motor Activity, Motor Skills.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesias.
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease.
- physiology : Body Weight, Motor Activity.
- radiation effects : Body Weight, Motor Skills, Subthalamic Nucleus.
- surgery : Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Analysis of Variance, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Treatment Outcome.
Abstract
Patients with advanced Parkinson's disease (PD) and motor complications can obtain significant symptom improvement by deep brain stimulation (DBS) of the subthalamic nucleus (STN). Very little is published, however, about long‐term effect and disease evolution during DBS. We performed a 4‐year prospective study of the first 22 consecutive patients treated with STN DBS. The patients were evaluated with Unified Parkinson's Disease Rating Scale Part II to VI and a patient diary concerning on–off periods and dyskinesia. Patients were scored before surgery on medication and off medication for 10 to 12 hours and in four conditions 1 and 4 years after surgery: off medication ± stimulation and on medication ± stimulation. In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation. Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%). On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years. To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder. Five patients developed dementia. Severe adverse events were not observed. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20776
Affiliations:
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Le document en format XML
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Very little is published, however, about long‐term effect and disease evolution during DBS. We performed a 4‐year prospective study of the first 22 consecutive patients treated with STN DBS. The patients were evaluated with Unified Parkinson's Disease Rating Scale Part II to VI and a patient diary concerning on–off periods and dyskinesia. Patients were scored before surgery on medication and off medication for 10 to 12 hours and in four conditions 1 and 4 years after surgery: off medication ± stimulation and on medication ± stimulation. In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation. Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%). On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years. To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder. Five patients developed dementia. Severe adverse events were not observed. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name></noRegion><name sortKey="Aa Sunde, Niels" sort="Aa Sunde, Niels" uniqKey="Aa Sunde N" first="Niels" last="Aa. Sunde">Niels Aa. Sunde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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