Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
Identifieur interne : 004B99 ( Main/Merge ); précédent : 004B98; suivant : 004C00Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus
Auteurs : Karen Stergaard [Danemark] ; Niels Aa. Sunde [Danemark]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
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- Pascal (Inist)
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Abstract
Patients with advanced Parkinson's disease (PD) and motor complications can obtain significant symptom improvement by deep brain stimulation (DBS) of the subthalamic nucleus (STN). Very little is published, however, about long-term effect and disease evolution during DBS. We performed a 4-year prospective study of the first 22 consecutive patients treated with STN DBS. The patients were evaluated with Unified Parkinson's Disease Rating Scale Part II to VI and a patient diary concerning on-off periods and dyskinesia. Patients were scored before surgery on medication and off medication for 10 to 12 hours and in four conditions 1 and 4 years after surgery: off medication ± stimulation and on medication ± stimulation. In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation. Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%). On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years. To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder. Five patients developed dementia. Severe adverse events were not observed.
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Pascal:06-0289027Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus</title><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Aarhus University Hospital, Nørrebrogade</s1><s2>Aarhus C</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author><author><name sortKey="Sunde, Niels Aa" sort="Sunde, Niels Aa" uniqKey="Sunde N" first="Niels Aa." last="Sunde">Niels Aa. Sunde</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Aarhus University Hospital, Nørrebrogade</s1><s2>Aarhus C</s2><s3>DNK</s3><sZ>2 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0289027</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0289027 INIST</idno><idno type="RBID">Pascal:06-0289027</idno><idno type="wicri:Area/PascalFrancis/Corpus">001B57</idno><idno type="wicri:Area/PascalFrancis/Curation">001164</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001B04</idno><idno type="wicri:doubleKey">0885-3185:2006: Stergaard K:evolution:of:parkinson</idno><idno type="wicri:Area/Main/Merge">004B99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus</title><author><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Aarhus University Hospital, Nørrebrogade</s1><s2>Aarhus C</s2><s3>DNK</s3><sZ>1 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author><author><name sortKey="Sunde, Niels Aa" sort="Sunde, Niels Aa" uniqKey="Sunde N" first="Niels Aa." last="Sunde">Niels Aa. Sunde</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery, Aarhus University Hospital, Nørrebrogade</s1><s2>Aarhus C</s2><s3>DNK</s3><sZ>2 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Aarhus C</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term><term>Evolution</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Evolution</term><term>Noyau sousthalamique</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with advanced Parkinson's disease (PD) and motor complications can obtain significant symptom improvement by deep brain stimulation (DBS) of the subthalamic nucleus (STN). Very little is published, however, about long-term effect and disease evolution during DBS. We performed a 4-year prospective study of the first 22 consecutive patients treated with STN DBS. The patients were evaluated with Unified Parkinson's Disease Rating Scale Part II to VI and a patient diary concerning on-off periods and dyskinesia. Patients were scored before surgery on medication and off medication for 10 to 12 hours and in four conditions 1 and 4 years after surgery: off medication ± stimulation and on medication ± stimulation. In advanced PD, a significant reduction of dyskinesia and off periods was present 4 years (90%/67%) after the operation. Total motor function on stimulation alone improved 55% at 4 years, compared with baseline and activities of daily living (42%). On stimulation, significant worsening of axial symptoms and speech was present from 1 to 4 years. To evaluate disease evolution, motor symptoms were assessed off stimulation and medication for 12 hours and were found not to worsen compared with baseline, which is remarkable in an otherwise progressive disorder. Five patients developed dementia. Severe adverse events were not observed.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name></noRegion><name sortKey="Sunde, Niels Aa" sort="Sunde, Niels Aa" uniqKey="Sunde N" first="Niels Aa." last="Sunde">Niels Aa. Sunde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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