A pilot tolerability and efficacy trial of sodium oxybate in ethanol‐responsive movement disorders
Identifieur interne : 003A45 ( Main/Exploration ); précédent : 003A44; suivant : 003A46A pilot tolerability and efficacy trial of sodium oxybate in ethanol‐responsive movement disorders
Auteurs : Steven J. Frucht [États-Unis] ; Yvette Bordelon [États-Unis] ; William H. Houghton [États-Unis] ; Dayton Reardan [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adjuvants, Anesthesia (adverse effects), Adjuvants, Anesthesia (therapeutic use), Adult, Aged, Central Nervous System Depressants (adverse effects), Central Nervous System Depressants (therapeutic use), Drug Administration Schedule, Drug Therapy, Combination, Dystonia (diagnosis), Dystonia (drug therapy), Essential Tremor (diagnosis), Essential Tremor (drug therapy), Ethanol, Ethanol (adverse effects), Ethanol (therapeutic use), Female, Humans, Male, Myoclonus, Myoclonus (diagnosis), Myoclonus (drug therapy), Nervous system diseases, Pilot Projects, Severity of Illness Index, Sodium Oxybate (adverse effects), Sodium Oxybate (therapeutic use), Sodium oxybate, Treatment Outcome, Tremor, Xyrem, ethanol, myoclonus, sodium oxybate, tremor, γ‐hydroxybutyric acid.
- MESH :
- chemical , adverse effects : Adjuvants, Anesthesia, Central Nervous System Depressants, Ethanol, Sodium Oxybate.
- chemical , therapeutic use : Adjuvants, Anesthesia, Central Nervous System Depressants, Ethanol, Sodium Oxybate.
- diagnosis : Dystonia, Essential Tremor, Myoclonus.
- drug therapy : Dystonia, Essential Tremor, Myoclonus.
- Adult, Aged, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Pilot Projects, Severity of Illness Index, Treatment Outcome.
Abstract
Sodium oxybate is currently approved in the United States exclusively for the treatment of cataplexy in narcoleptic patients. In a prior article published in this journal, we reported a patient with severe posthypoxic myoclonus whose myoclonus improved with ethanol and also with treatment with sodium oxybate. We extend this preliminary observation to five other patients with ethanol‐responsive movement disorders in an open‐label, dose‐titration, add‐on, 8‐week trial. All five patients (one with severe alcohol‐responsive posthypoxic myoclonus, two with ϵ‐sarcoglycan–linked myoclonus–dystonia, and two with essential tremor) experienced improvement from baseline of 50% or greater as measured by blinded videotape review. Tolerability was satisfactory, with dose‐dependent sedation as the most common side effect. Further studies of this drug in hyperkinetic movement disorders are warranted. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20605
Affiliations:
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Le document en format XML
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<term>Aged</term>
<term>Central Nervous System Depressants (adverse effects)</term>
<term>Central Nervous System Depressants (therapeutic use)</term>
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<term>Drug Therapy, Combination</term>
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<term>Dystonia (drug therapy)</term>
<term>Essential Tremor (diagnosis)</term>
<term>Essential Tremor (drug therapy)</term>
<term>Ethanol</term>
<term>Ethanol (adverse effects)</term>
<term>Ethanol (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
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<term>Myoclonus</term>
<term>Myoclonus (diagnosis)</term>
<term>Myoclonus (drug therapy)</term>
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<term>Pilot Projects</term>
<term>Severity of Illness Index</term>
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<term>ethanol</term>
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<term>sodium oxybate</term>
<term>tremor</term>
<term>γ‐hydroxybutyric acid</term>
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<term>Ethanol</term>
<term>Sodium Oxybate</term>
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<term>Central Nervous System Depressants</term>
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<term>Sodium Oxybate</term>
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<term>Essential Tremor</term>
<term>Myoclonus</term>
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<front><div type="abstract" xml:lang="en">Sodium oxybate is currently approved in the United States exclusively for the treatment of cataplexy in narcoleptic patients. In a prior article published in this journal, we reported a patient with severe posthypoxic myoclonus whose myoclonus improved with ethanol and also with treatment with sodium oxybate. We extend this preliminary observation to five other patients with ethanol‐responsive movement disorders in an open‐label, dose‐titration, add‐on, 8‐week trial. All five patients (one with severe alcohol‐responsive posthypoxic myoclonus, two with ϵ‐sarcoglycan–linked myoclonus–dystonia, and two with essential tremor) experienced improvement from baseline of 50% or greater as measured by blinded videotape review. Tolerability was satisfactory, with dose‐dependent sedation as the most common side effect. Further studies of this drug in hyperkinetic movement disorders are warranted. © 2005 Movement Disorder Society</div>
</front>
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