Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization
Identifieur interne : 004B46 ( Main/Exploration ); précédent : 004B45; suivant : 004B47Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization
Auteurs : Anumantha G. Kanthasamy [États-Unis] ; Bang Q. Nguyen [États-Unis] ; Daniel D. Truong [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Oxygène, Pharmacologie.
English descriptors
- KwdEn :
- Animal, Animal model, Animals, Anticonvulsant, Behavioral disorder, Brain (pathology), Brain (physiopathology), Brain Mapping, Cardiac arrest, Cardiocirculatory arrest, DDT, Disease Models, Animal, Epilepsies, Myoclonic (pathology), Epilepsies, Myoclonic (physiopathology), Exploration, Hypoxia, Hypoxia, Brain (pathology), Hypoxia, Brain (physiopathology), Lamotrigine, Male, Movement disorder, Myoclonus, Myoclonus (pathology), Myoclonus (physiopathology), Oxygen, Pathology, Pharmacology, Rat, Rats, Rats, Sprague-Dawley, Review, Riluzole, Serotonin, Serotonin (physiology), Symptomatology.
- MESH :
- chemical , physiology : Serotonin.
- pathology : Brain, Epilepsies, Myoclonic, Hypoxia, Brain, Myoclonus.
- physiopathology : Brain, Epilepsies, Myoclonic, Hypoxia, Brain, Myoclonus.
- Animals, Brain Mapping, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley.
Abstract
The sudden, brief, shock‐like, involuntary movements caused by active muscular contractions or inhibitions characterize myoclonus. It is manifested in a wide variety of pathologic conditions affecting the brain, spinal cord, or peripheral nerves, and is thought to be related to neuronal hyper‐excitability. The pathology, physiology, and pharmacology of myoclonus are not well understood as a result of the rarity of the disorder in people and the lack of a suitable animal model. Posthypoxic myoclonus is a major myoclonus syndrome which occurs as a result of severe cerebral ischemia/hypoxia. There has been tremendous interest in the development of a suitable animal model that reflects the etiology and clinical pathology of posthypoxic myoclonus. Recently, we have developed a new animal model of posthypoxic myoclonus in which rats were subjected to a mechanically induced cardiac arrest procedure. Herein, we describe the neurochemical, pharmacologic, and pathologic characteristics of this animal model of posthypoxic myoclonus.
Url:
DOI: 10.1002/mds.870150707
Affiliations:
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Le document en format XML
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It is manifested in a wide variety of pathologic conditions affecting the brain, spinal cord, or peripheral nerves, and is thought to be related to neuronal hyper‐excitability. The pathology, physiology, and pharmacology of myoclonus are not well understood as a result of the rarity of the disorder in people and the lack of a suitable animal model. Posthypoxic myoclonus is a major myoclonus syndrome which occurs as a result of severe cerebral ischemia/hypoxia. There has been tremendous interest in the development of a suitable animal model that reflects the etiology and clinical pathology of posthypoxic myoclonus. Recently, we have developed a new animal model of posthypoxic myoclonus in which rats were subjected to a mechanically induced cardiac arrest procedure. Herein, we describe the neurochemical, pharmacologic, and pathologic characteristics of this animal model of posthypoxic myoclonus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Kanthasamy, Anumantha G" sort="Kanthasamy, Anumantha G" uniqKey="Kanthasamy A" first="Anumantha G." last="Kanthasamy">Anumantha G. Kanthasamy</name></region><name sortKey="Kanthasamy, Anumantha G" sort="Kanthasamy, Anumantha G" uniqKey="Kanthasamy A" first="Anumantha G." last="Kanthasamy">Anumantha G. Kanthasamy</name><name sortKey="Nguyen, Bang Q" sort="Nguyen, Bang Q" uniqKey="Nguyen B" first="Bang Q." last="Nguyen">Bang Q. Nguyen</name><name sortKey="Nguyen, Bang Q" sort="Nguyen, Bang Q" uniqKey="Nguyen B" first="Bang Q." last="Nguyen">Bang Q. Nguyen</name><name sortKey="Truong, Daniel D" sort="Truong, Daniel D" uniqKey="Truong D" first="Daniel D." last="Truong">Daniel D. Truong</name><name sortKey="Truong, Daniel D" sort="Truong, Daniel D" uniqKey="Truong D" first="Daniel D." last="Truong">Daniel D. Truong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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