MovDisordV3, PubMed, Corpus, bibRecord, 003F92

Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization.

Identifieur interne : 003F92 ( PubMed/Corpus ); précédent : 003F91; suivant : 003F93

Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization.

Auteurs : A G Kanthasamy ; B Q Nguyen ; D D Truong

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.

RBID : pubmed:10755270

English descriptors

KwdEn :
- Animals, Brain (pathology), Brain (physiopathology), Brain Mapping, Disease Models, Animal, Epilepsies, Myoclonic (pathology), Epilepsies, Myoclonic (physiopathology), Hypoxia, Brain (pathology), Hypoxia, Brain (physiopathology), Male, Myoclonus (pathology), Myoclonus (physiopathology), Rats, Rats, Sprague-Dawley, Serotonin (physiology).
MESH :
- chemical , physiology : Serotonin.
- pathology : Brain, Epilepsies, Myoclonic, Hypoxia, Brain, Myoclonus.
- physiopathology : Brain, Epilepsies, Myoclonic, Hypoxia, Brain, Myoclonus.
- Animals, Brain Mapping, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley.

Abstract

The sudden, brief, shock-like, involuntary movements caused by active muscular contractions or inhibitions characterize myoclonus. It is manifested in a wide variety of pathologic conditions affecting the brain, spinal cord, or peripheral nerves, and is thought to be related to neuronal hyperexcitability. The pathology, physiology, and pharmacology of myoclonus are not well understood as a result of the rarity of the disorder in people and the lack of a suitable animal model. Posthypoxic myoclonus is a major myoclonus syndrome which occurs as a result of severe cerebral ischemia/hypoxia. There has been tremendous interest in the development of a suitable animal model that reflects the etiology and clinical pathology of posthypoxic myoclonus. Recently, we have developed a new animal model of posthypoxic myoclonus in which rats were subjected to a mechanically induced cardiac arrest procedure. Herein, we describe the neurochemical, pharmacologic, and pathologic characteristics of this animal model of posthypoxic myoclonus.

PubMed: 10755270

Links to Exploration step

pubmed:10755270

Le document en format XML

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<author><name sortKey="Kanthasamy, A G" sort="Kanthasamy, A G" uniqKey="Kanthasamy A" first="A G" last="Kanthasamy">A G Kanthasamy</name>
<affiliation><nlm:affiliation>The Parkinson's and Movement Disorder Institute, Long Beach Memorial Medical Center, California 92708, USA.</nlm:affiliation>
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<author><name sortKey="Nguyen, B Q" sort="Nguyen, B Q" uniqKey="Nguyen B" first="B Q" last="Nguyen">B Q Nguyen</name>
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<author><name sortKey="Truong, D D" sort="Truong, D D" uniqKey="Truong D" first="D D" last="Truong">D D Truong</name>
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<author><name sortKey="Nguyen, B Q" sort="Nguyen, B Q" uniqKey="Nguyen B" first="B Q" last="Nguyen">B Q Nguyen</name>
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<author><name sortKey="Truong, D D" sort="Truong, D D" uniqKey="Truong D" first="D D" last="Truong">D D Truong</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Disease Models, Animal</term>
<term>Epilepsies, Myoclonic (pathology)</term>
<term>Epilepsies, Myoclonic (physiopathology)</term>
<term>Hypoxia, Brain (pathology)</term>
<term>Hypoxia, Brain (physiopathology)</term>
<term>Male</term>
<term>Myoclonus (pathology)</term>
<term>Myoclonus (physiopathology)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Serotonin (physiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Serotonin</term>
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<term>Epilepsies, Myoclonic</term>
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<front><div type="abstract" xml:lang="en">The sudden, brief, shock-like, involuntary movements caused by active muscular contractions or inhibitions characterize myoclonus. It is manifested in a wide variety of pathologic conditions affecting the brain, spinal cord, or peripheral nerves, and is thought to be related to neuronal hyperexcitability. The pathology, physiology, and pharmacology of myoclonus are not well understood as a result of the rarity of the disorder in people and the lack of a suitable animal model. Posthypoxic myoclonus is a major myoclonus syndrome which occurs as a result of severe cerebral ischemia/hypoxia. There has been tremendous interest in the development of a suitable animal model that reflects the etiology and clinical pathology of posthypoxic myoclonus. Recently, we have developed a new animal model of posthypoxic myoclonus in which rats were subjected to a mechanically induced cardiac arrest procedure. Herein, we describe the neurochemical, pharmacologic, and pathologic characteristics of this animal model of posthypoxic myoclonus.</div>
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<DateCompleted><Year>2000</Year>
<Month>05</Month>
<Day>25</Day>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>The sudden, brief, shock-like, involuntary movements caused by active muscular contractions or inhibitions characterize myoclonus. It is manifested in a wide variety of pathologic conditions affecting the brain, spinal cord, or peripheral nerves, and is thought to be related to neuronal hyperexcitability. The pathology, physiology, and pharmacology of myoclonus are not well understood as a result of the rarity of the disorder in people and the lack of a suitable animal model. Posthypoxic myoclonus is a major myoclonus syndrome which occurs as a result of severe cerebral ischemia/hypoxia. There has been tremendous interest in the development of a suitable animal model that reflects the etiology and clinical pathology of posthypoxic myoclonus. Recently, we have developed a new animal model of posthypoxic myoclonus in which rats were subjected to a mechanically induced cardiac arrest procedure. Herein, we describe the neurochemical, pharmacologic, and pathologic characteristics of this animal model of posthypoxic myoclonus.</AbstractText>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017207">Rats, Sprague-Dawley</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012701">Serotonin</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization.

Animal model of posthypoxic myoclonus: II. Neurochemical, pathologic, and pharmacologic characterization.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki