MovDisordV3, Main, Exploration, bibRecordById, Pascal:09-0058900

Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: Preliminary observations

Identifieur interne : 002908 ( Main/Exploration ); précédent : 002907; suivant : 002909

Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: Preliminary observations

Auteurs : Alberto J. Espay [États-Unis] ; Andrew P. Duker [États-Unis] ; Robert Chen [Canada] ; Michael S. Okun [États-Unis] ; Edwin T. Barrett [États-Unis] ; Johnna Devoto [États-Unis] ; Pamela Zeilman [États-Unis] ; Maureen Gartner [États-Unis] ; Noël Burton [États-Unis] ; Helard A. Miranda [États-Unis] ; George T. Mandybur [États-Unis] ; Theresa A. Zesiewicz [États-Unis] ; Kelly D. Foote [États-Unis] ; Fredy J. Revilla [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-12-15.

RBID : ISTEX:E07358661810EE608DE44EE76AED621B483D477A

Descripteurs français

Pascal (Inist)
- Noyau ventral, Pathologie du système nerveux, Réfractaire, Stimulation cérébrale profonde, Thalamus, Tremblement.

English descriptors

KwdEn :
- Aged, Deep Brain Stimulation (methods), Deep brain stimulation, Electromyography (methods), Female, Humans, Nervous system diseases, Neuropsychological Tests, Refractory, Thalamus, Thalamus (physiology), Thalamus (surgery), Tremor, Tremor (physiopathology), Tremor (therapy), Ventral nucleus, deep brain stimulation, orthostatic tremor, ventral intermediate nucleus of the thalamus.
MESH :
- methods : Deep Brain Stimulation, Electromyography.
- physiology : Thalamus.
- physiopathology : Tremor.
- surgery : Thalamus.
- therapy : Tremor.
- Aged, Female, Humans, Neuropsychological Tests.

Abstract

Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report the clinical and electrophysiological data on two patients with medication‐refractory OT treated with deep brain stimulation of the ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral deep brain stimulation (DBS) and Patient 2 unilateral Vim DBS following 28 and 30 years of disease duration, respectively. Both patients showed increased latency to symptom onset after rising from a seated position, improved tolerance for prolonged standing, and slower crescendo of tremor severity when remaining upright. Postoperative evaluation demonstrated decreased amplitude of electromyographic activity with persistence of well‐defined oscillatory behavior showing strong coherence at 15 Hz between all muscles tested in the upper and lower limbs. Postural sway was unchanged. Clinical benefits have been sustained for over 18 months in Patient 1, and receded after 3 months in Patient 2. These findings support the consideration of bilateral Vim DBS implantation as a therapeutic option in patients with medically refractory OT. Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/E07358661810EE608DE44EE76AED621B483D477A/fulltext/pdf

DOI: 10.1002/mds.22271

Affiliations:

Le document en format XML

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<term>Deep Brain Stimulation (methods)</term>
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<term>Electromyography (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Refractory</term>
<term>Thalamus</term>
<term>Thalamus (physiology)</term>
<term>Thalamus (surgery)</term>
<term>Tremor</term>
<term>Tremor (physiopathology)</term>
<term>Tremor (therapy)</term>
<term>Ventral nucleus</term>
<term>deep brain stimulation</term>
<term>orthostatic tremor</term>
<term>ventral intermediate nucleus of the thalamus</term>
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<term>Electromyography</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Tremor</term>
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<term>Pathologie du   système nerveux</term>
<term>Réfractaire</term>
<term>Stimulation cérébrale profonde</term>
<term>Thalamus</term>
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<front><div type="abstract" xml:lang="en">Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report the clinical and electrophysiological data on two patients with medication‐refractory OT treated with deep brain stimulation of the ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral deep brain stimulation (DBS) and Patient 2 unilateral Vim DBS following 28 and 30 years of disease duration, respectively. Both patients showed increased latency to symptom onset after rising from a seated position, improved tolerance for prolonged standing, and slower crescendo of tremor severity when remaining upright. Postoperative evaluation demonstrated decreased amplitude of electromyographic activity with persistence of well‐defined oscillatory behavior showing strong coherence at 15 Hz between all muscles tested in the upper and lower limbs. Postural sway was unchanged. Clinical benefits have been sustained for over 18 months in Patient 1, and receded after 3 months in Patient 2. These findings support the consideration of bilateral Vim DBS implantation as a therapeutic option in patients with medically refractory OT. Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted. © 2008 Movement Disorder Society</div>
</front>
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<name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name>
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Movement Disorders (revue)

Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: Preliminary observations

Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: Preliminary observations

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Descripteurs français

English descriptors

Abstract

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Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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