MovDisordV3, PascalFrancis, Curation, bibRecord, 001C84

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations

Identifieur interne : 001C84 ( PascalFrancis/Curation ); précédent : 001C83; suivant : 001C85

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations

Auteurs : Alberto J. Espay [États-Unis] ; Andrew P. Duker [États-Unis] ; Robert Chen [Canada] ; Michael S. Okun [États-Unis] ; Edwin T. Barrett [États-Unis] ; Johnna Devoto [États-Unis] ; Pamela Zeilman [États-Unis] ; Maureen Gartner [États-Unis] ; Noël Burton [États-Unis] ; Helard A. Miranda [États-Unis] ; George T. Mandybur [États-Unis] ; Theresa A. Zesiewicz [États-Unis] ; Kelly D. Foote [États-Unis] ; Fredy J. Revilla [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0058900

Descripteurs français

Pascal (Inist)
- Tremblement, Pathologie du système nerveux, Noyau ventral, Thalamus, Réfractaire, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Nervous system diseases, Refractory, Thalamus, Tremor, Ventral nucleus.

Abstract

Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report the clinical and electrophysiological data on two patients with medication-refractory OT treated with deep brain stimulation of the ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral deep brain stimulation (DBS) and Patient 2 unilateral Vim DBS following 28 and 30 years of disease duration, respectively. Both patients showed increased latency to symptom onset after rising from a seated position, improved tolerance for prolonged standing, and slower crescendo of tremor severity when remaining upright. Postoperative evaluation demonstrated decreased amplitude of electromyographic activity with persistence of well-defined oscillatory behavior showing strong coherence at 15 Hz between all muscles tested in the upper and lower limbs. Postural sway was unchanged. Clinical benefits have been sustained for over 18 months in Patient 1, and receded after 3 months in Patient 2. These findings support the consideration of bilateral Vim DBS implantation as a therapeutic option in patients with medically refractory OT. Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted.

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A03		`1`		`@0 Mov. disord.`
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A08	`01`	`1`	`ENG`	`@1 Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations`
A11	`01`	`1`		`@1 ESPAY (Alberto J.)`
A11	`02`	`1`		`@1 DUKER (Andrew P.)`
A11	`03`	`1`		`@1 CHEN (Robert)`
A11	`04`	`1`		`@1 OKUN (Michael S.)`
A11	`05`	`1`		`@1 BARRETT (Edwin T.)`
A11	`06`	`1`		`@1 DEVOTO (Johnna)`
A11	`07`	`1`		`@1 ZEILMAN (Pamela)`
A11	`08`	`1`		`@1 GARTNER (Maureen)`
A11	`09`	`1`		`@1 BURTON (Noël)`
A11	`10`	`1`		`@1 MIRANDA (Helard A.)`
A11	`11`	`1`		`@1 MANDYBUR (George T.)`
A11	`12`	`1`		`@1 ZESIEWICZ (Theresa A.)`
A11	`13`	`1`		`@1 FOOTE (Kelly D.)`
A11	`14`	`1`		`@1 REVILLA (Fredy J.)`
A14	`01`			`@1 Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati @2 Cincinnati, Ohio @3 USA @Z 1 aut. @Z 2 aut. @Z 5 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 11 aut. @Z 14 aut.`
A14	`02`			`@1 Toronto Western Research Institute, Toronto Western Hospital @2 Toronto, Ontario @3 CAN @Z 3 aut.`
A14	`03`			`@1 Division of Neurology, Department of Medicine, University of Toronto @2 Toronto, Ontario @3 CAN @Z 3 aut.`
A14	`04`			`@1 Department of Neurology, McKnight Brain Institute, Movement Disorders Center, University of Florida College of Medicine @2 Gainesville, Florida @3 USA @Z 4 aut. @Z 7 aut. @Z 13 aut.`
A14	`05`			`@1 Department of Neurology, University of South Florida @2 Tampa, Florida @3 USA @Z 12 aut.`
A20				`@1 2357-2362`
A21				`@1 2008`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
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C01	`01`		`ENG`	@0 Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report the clinical and electrophysiological data on two patients with medication-refractory OT treated with deep brain stimulation of the ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral deep brain stimulation (DBS) and Patient 2 unilateral Vim DBS following 28 and 30 years of disease duration, respectively. Both patients showed increased latency to symptom onset after rising from a seated position, improved tolerance for prolonged standing, and slower crescendo of tremor severity when remaining upright. Postoperative evaluation demonstrated decreased amplitude of electromyographic activity with persistence of well-defined oscillatory behavior showing strong coherence at 15 Hz between all muscles tested in the upper and lower limbs. Postural sway was unchanged. Clinical benefits have been sustained for over 18 months in Patient 1, and receded after 3 months in Patient 2. These findings support the consideration of bilateral Vim DBS implantation as a therapeutic option in patients with medically refractory OT. Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17A01`
C03	`01`	`X`	`FRE`	`@0 Tremblement @5 01`
C03	`01`	`X`	`ENG`	`@0 Tremor @5 01`
C03	`01`	`X`	`SPA`	`@0 Temblor @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Noyau ventral @5 09`
C03	`03`	`X`	`ENG`	`@0 Ventral nucleus @5 09`
C03	`03`	`X`	`SPA`	`@0 Núcleo ventral @5 09`
C03	`04`	`X`	`FRE`	`@0 Thalamus @5 10`
C03	`04`	`X`	`ENG`	`@0 Thalamus @5 10`
C03	`04`	`X`	`SPA`	`@0 Tálamo @5 10`
C03	`05`	`X`	`FRE`	`@0 Réfractaire @5 11`
C03	`05`	`X`	`ENG`	`@0 Refractory @5 11`
C03	`05`	`X`	`SPA`	`@0 Refractario @5 11`
C03	`06`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Encephalon @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso central @5 38`
C07	`03`	`X`	`FRE`	`@0 Mouvement involontaire @5 39`
C07	`03`	`X`	`ENG`	`@0 Involuntary movement @5 39`
C07	`03`	`X`	`SPA`	`@0 Movimiento involuntario @5 39`
C07	`04`	`X`	`FRE`	`@0 Trouble neurologique @5 41`
C07	`04`	`X`	`ENG`	`@0 Neurological disorder @5 41`
C07	`04`	`X`	`SPA`	`@0 Trastorno neurológico @5 41`
N21				`@1 040`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:09-0058900

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations</title>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
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<author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name>
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<author><name sortKey="Barrett, Edwin T" sort="Barrett, Edwin T" uniqKey="Barrett E" first="Edwin T." last="Barrett">Edwin T. Barrett</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
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<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
<s2>Cincinnati, Ohio</s2>
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<author><name sortKey="Zeilman, Pamela" sort="Zeilman, Pamela" uniqKey="Zeilman P" first="Pamela" last="Zeilman">Pamela Zeilman</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, McKnight Brain Institute, Movement Disorders Center, University of Florida College of Medicine</s1>
<s2>Gainesville, Florida</s2>
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<author><name sortKey="Gartner, Maureen" sort="Gartner, Maureen" uniqKey="Gartner M" first="Maureen" last="Gartner">Maureen Gartner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
<s2>Cincinnati, Ohio</s2>
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<author><name sortKey="Burton, Noel" sort="Burton, Noel" uniqKey="Burton N" first="Noël" last="Burton">Noël Burton</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
<s2>Cincinnati, Ohio</s2>
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<author><name sortKey="Miranda, Helard A" sort="Miranda, Helard A" uniqKey="Miranda H" first="Helard A." last="Miranda">Helard A. Miranda</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
<s2>Cincinnati, Ohio</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, Florida</s2>
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<country>États-Unis</country>
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<author><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D." last="Foote">Kelly D. Foote</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, McKnight Brain Institute, Movement Disorders Center, University of Florida College of Medicine</s1>
<s2>Gainesville, Florida</s2>
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<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J." last="Revilla">Fredy J. Revilla</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The Neuroscience Institute, Movement Disorders Center, University of Cincinnati</s1>
<s2>Cincinnati, Ohio</s2>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Ventral nucleus</term>
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<front><div type="abstract" xml:lang="en">Orthostatic tremor (OT) is a disabling movement disorder associated with postural and gait impairment in the elderly. Medical therapy often yields insufficient benefit. We report the clinical and electrophysiological data on two patients with medication-refractory OT treated with deep brain stimulation of the ventral intermediate thalamic nucleus (Vim DBS). Patient 1 underwent bilateral deep brain stimulation (DBS) and Patient 2 unilateral Vim DBS following 28 and 30 years of disease duration, respectively. Both patients showed increased latency to symptom onset after rising from a seated position, improved tolerance for prolonged standing, and slower crescendo of tremor severity when remaining upright. Postoperative evaluation demonstrated decreased amplitude of electromyographic activity with persistence of well-defined oscillatory behavior showing strong coherence at 15 Hz between all muscles tested in the upper and lower limbs. Postural sway was unchanged. Clinical benefits have been sustained for over 18 months in Patient 1, and receded after 3 months in Patient 2. These findings support the consideration of bilateral Vim DBS implantation as a therapeutic option in patients with medically refractory OT. Further efficacy studies on chronic stimulation to disrupt the abnormal oscillatory activity in this disorder are warranted.</div>
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<fA14 i1="04"><s1>Department of Neurology, McKnight Brain Institute, Movement Disorders Center, University of Florida College of Medicine</s1>
<s2>Gainesville, Florida</s2>
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<sZ>7 aut.</sZ>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Medically Refractory Orthostatic Tremor : Preliminary Observations

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