Irresistible onset of sleep during acute levodopa challenge in a patient with multiple system atrophy (MSA): Placebo‐controlled, polysomnographic case report
Identifieur interne : 004767 ( Main/Exploration ); précédent : 004766; suivant : 004768Irresistible onset of sleep during acute levodopa challenge in a patient with multiple system atrophy (MSA): Placebo‐controlled, polysomnographic case report
Auteurs : Birgit Högl ; Klaus Seppi ; Elisabeth Brandauer ; Gregor Wenning ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Acute, Aged, Antiparkinson agent, Case study, Chemotherapy, Cross-Over Studies, Disorders of Excessive Somnolence (chemically induced), Disorders of Excessive Somnolence (physiopathology), Dopamine Agents (adverse effects), Double-Blind Method, Electrodiagnosis, Human, Humans, Levodopa, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Multiple System Atrophy (diagnosis), Multiple System Atrophy (physiopathology), Multiple system atrophy, Polygraphy, Polysomnography, Sleep, Sleep Stages (drug effects), Somnolence, Toxicity, Video recording.
- MESH :
- chemical , administration & dosage : Levodopa.
- chemical , adverse effects : Dopamine Agents, Levodopa.
- chemically induced : Disorders of Excessive Somnolence.
- diagnosis : Multiple System Atrophy.
- drug effects : Sleep Stages.
- physiopathology : Disorders of Excessive Somnolence, Multiple System Atrophy.
- Aged, Cross-Over Studies, Double-Blind Method, Humans, Male, Polysomnography.
Abstract
A 67‐year‐old male patient with clinically probable multiple system atrophy developed severe reproducible sleepiness and irresistible onset of sleep during an acute levodopa (L‐dopa) challenge. In a placebo‐controlled, double‐blind study of acute L‐dopa challenge, videopolysomnography revealed multiple episodes of non‐rapid eye movement sleep 60 minutes after L‐dopa and none following placebo. These observations suggest the irresistible sleep can also be induced by L‐dopa and also in patients with atypical parkinsonism. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1207
Affiliations:
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Le document en format XML
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<term>Chemotherapy</term>
<term>Cross-Over Studies</term>
<term>Disorders of Excessive Somnolence (chemically induced)</term>
<term>Disorders of Excessive Somnolence (physiopathology)</term>
<term>Dopamine Agents (adverse effects)</term>
<term>Double-Blind Method</term>
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<term>Multiple System Atrophy (physiopathology)</term>
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<term>Sleep</term>
<term>Sleep Stages (drug effects)</term>
<term>Somnolence</term>
<term>Toxicity</term>
<term>Video recording</term>
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<term>Multiple System Atrophy</term>
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<term>Cross-Over Studies</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Male</term>
<term>Polysomnography</term>
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<term>Antiparkinsonien</term>
<term>Atrophie multisystématisée</term>
<term>Chimiothérapie</term>
<term>Electrodiagnostic</term>
<term>Enregistrement vidéo</term>
<term>Etude cas</term>
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<term>Sommeil</term>
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<front><div type="abstract" xml:lang="en">A 67‐year‐old male patient with clinically probable multiple system atrophy developed severe reproducible sleepiness and irresistible onset of sleep during an acute levodopa (L‐dopa) challenge. In a placebo‐controlled, double‐blind study of acute L‐dopa challenge, videopolysomnography revealed multiple episodes of non‐rapid eye movement sleep 60 minutes after L‐dopa and none following placebo. These observations suggest the irresistible sleep can also be induced by L‐dopa and also in patients with atypical parkinsonism. © 2001 Movement Disorder Society.</div>
</front>
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<name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
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