Employment, medical absenteeism, and disability perception in Parkinson's disease: A pilot double‐blind, randomized, placebo‐controlled study of entacapone adjunctive therapy
Identifieur interne : 003450 ( Main/Exploration ); précédent : 003449; suivant : 003451Employment, medical absenteeism, and disability perception in Parkinson's disease: A pilot double‐blind, randomized, placebo‐controlled study of entacapone adjunctive therapy
Auteurs : Alexei Korchounov [Allemagne, Égypte] ; Gregory Bogomazov [Russie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Absenteeism, Antiparkinson Agents (therapeutic use), Catechols (therapeutic use), Disability, Disability Evaluation, Double blind study, Double-Blind Method, Drug Therapy, Combination, Dyskinesia, Employment, Entacapone, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Nitriles (therapeutic use), Outcome Assessment (Health Care), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Perception, Placebo, Self Concept, Treatment, dyskinesia, employment, entacapone, retirement.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Catechols, Levodopa, Nitriles.
- drug therapy : Parkinson Disease.
- psychology : Parkinson Disease.
- Absenteeism, Disability Evaluation, Double-Blind Method, Drug Therapy, Combination, Employment, Female, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Self Concept.
Abstract
The objective of this study was to test the impact of entacapone (ENT) addition to levodopa with a decarboxylase inhibitor (LD) in full‐time–employed patients with Parkinson's disease (PD), focusing on retirement rates, medical absenteeism, self‐perception of disability, as well as motor assessments of parkinsonism, motor fluctuations, and dyskinesias. Thirty full‐time–employed PD patients (disease onset before age 60 years) and on optimized monotherapy with LD exhibiting minor motor fluctuations or dyskinesias were entered into a 2‐year randomized double‐blind placebo‐controlled study of ENT adjunctive therapy. The outcome measures were the number of full‐time–employed patients at study end, cumulative days of medical absenteeism, patient‐completed disability assessments, diary records, and the Unified Parkinson's Disease Rating Scale–based measures of motor fluctuations and dyskinesias. LD + ENT treatment was associated with a lower retirement rate (2 [17%] of 12 vs. 6 [50%] of 12; P = 0.12), lower absenteeism rate (21.5 vs. 43.5 days; P < 0.0001), improved self‐perception of disability progression over 2 years (change score 1.0 vs. 4.5; P < 0.0001), and lower scores for both motor fluctuations and dyskinesia assessments compared to LD monotherapy. In this pilot study, LD with ENT adjunctive therapy positively influenced employment rate over 2 years; this effect was associated with reduced motor complications and patient perceptions of stabilized disability. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21123
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-12">2006-12</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2220">2220</biblScope><biblScope unit="page" to="2224">2224</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C100D1EB96F2628E5CB83422D95BDD30C8E3D788</idno><idno type="DOI">10.1002/mds.21123</idno><idno type="ArticleID">MDS21123</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absenteeism</term><term>Antiparkinson Agents (therapeutic use)</term><term>Catechols (therapeutic use)</term><term>Disability</term><term>Disability Evaluation</term><term>Double blind study</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Dyskinesia</term><term>Employment</term><term>Entacapone</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nitriles (therapeutic use)</term><term>Outcome Assessment (Health Care)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Perception</term><term>Placebo</term><term>Self Concept</term><term>Treatment</term><term>dyskinesia</term><term>employment</term><term>entacapone</term><term>retirement</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Catechols</term><term>Levodopa</term><term>Nitriles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Absenteeism</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Employment</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Self Concept</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Entacapone</term><term>Etude double insu</term><term>Incapacité</term><term>Parkinson maladie</term><term>Perception</term><term>Placebo</term><term>Système nerveux pathologie</term><term>Traitement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to test the impact of entacapone (ENT) addition to levodopa with a decarboxylase inhibitor (LD) in full‐time–employed patients with Parkinson's disease (PD), focusing on retirement rates, medical absenteeism, self‐perception of disability, as well as motor assessments of parkinsonism, motor fluctuations, and dyskinesias. Thirty full‐time–employed PD patients (disease onset before age 60 years) and on optimized monotherapy with LD exhibiting minor motor fluctuations or dyskinesias were entered into a 2‐year randomized double‐blind placebo‐controlled study of ENT adjunctive therapy. The outcome measures were the number of full‐time–employed patients at study end, cumulative days of medical absenteeism, patient‐completed disability assessments, diary records, and the Unified Parkinson's Disease Rating Scale–based measures of motor fluctuations and dyskinesias. LD + ENT treatment was associated with a lower retirement rate (2 [17%] of 12 vs. 6 [50%] of 12; P = 0.12), lower absenteeism rate (21.5 vs. 43.5 days; P < 0.0001), improved self‐perception of disability progression over 2 years (change score 1.0 vs. 4.5; P < 0.0001), and lower scores for both motor fluctuations and dyskinesia assessments compared to LD monotherapy. In this pilot study, LD with ENT adjunctive therapy positively influenced employment rate over 2 years; this effect was associated with reduced motor complications and patient perceptions of stabilized disability. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Russie</li><li>Égypte</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Korchounov, Alexei" sort="Korchounov, Alexei" uniqKey="Korchounov A" first="Alexei" last="Korchounov">Alexei Korchounov</name></noRegion></country><country name="Égypte"><noRegion><name sortKey="Korchounov, Alexei" sort="Korchounov, Alexei" uniqKey="Korchounov A" first="Alexei" last="Korchounov">Alexei Korchounov</name></noRegion></country><country name="Russie"><region name="District fédéral central"><name sortKey="Bogomazov, Gregory" sort="Bogomazov, Gregory" uniqKey="Bogomazov G" first="Gregory" last="Bogomazov">Gregory Bogomazov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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