What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?
Identifieur interne : 001912 ( Main/Exploration ); précédent : 001911; suivant : 001913What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?
Auteurs : David A. Gallagher [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Anette Schrag [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-11-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Autonomic Nervous System Diseases (complications), Depression, Depression (complications), Fatigue (complications), Female, Health Surveys, Human, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Quality of Life, Quality of life, Questionnaires, Severity of Illness Index, Sleep Disorders (complications), autonomic, depression, quality of Life.
- MESH :
- complications : Autonomic Nervous System Diseases, Depression, Fatigue, Parkinson Disease, Sleep Disorders.
- diagnosis : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Aged, Female, Health Surveys, Humans, Male, Middle Aged, Quality of Life, Questionnaires, Severity of Illness Index.
Abstract
Nonmotor symptoms (NMS) are increasingly recognized as important and neglected aspects of Parkinson's disease (PD). We evaluated their relative frequency and comparative impact on health‐related quality of life (Hr‐QoL) using validated questionnaires. In addition, we assessed the rate of reporting of NMS in neurology clinics compared with their subjective impact on patients. We used a range of validated clinimetric scales of motor and nonmotor symptoms and Hr‐QoL to assess consecutive patients with PD. Reporting of NMS was assessed by comparison with case note documentation. A mean of 11 of 30 NMS per patient were elicited on the NMS questionnaire of which on average 4.8 were reported in the clinical notes (44%). The most common NMS were autonomic (particularly urinary). The Hr‐QoL scores correlated most strongly with autonomic dysfunction (r = 0.84; particularly urinary and gastrointestinal symptoms), mood (r = 0.74), fatigue (r = 0.74), sleep problems (nocturnal r = 0.55; daytime somnolence r = 0.65), pain (r = 0.56), and psychosis (r = 0.55, all p < 0.0001) followed by UPDRS motor score (r = 0.48, p < 0.0001). Greater motor fluctuations (r = 0.57) and dyskinesia (r = 0.43, both p < 0.0001) were also associated with worse Hr‐QoL. In multivariate analysis, depression had the strongest association with Hr‐QoL (adjusted R2 = 0.53, p = 0.005) followed by fatigue, thermoregulatory, gastrointestinal, and cardiovascular autonomic function (especially orthostatic hypotension), daytime somnolence, and urinary problems. This study demonstrates that a autonomic dysfunction, psychiatric complications, pain, fatigue, and sleep problems are major correlates of poor Hr‐QoL. However, whilst psychiatric problems are increasingly documented, many symptoms (particularly those possibly perceived as embarrassing or unrelated) remain under‐reported. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23394
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000536
- to stream Istex, to step Curation: 000536
- to stream Istex, to step Checkpoint: 000591
- to stream PubMed, to step Corpus: 001541
- to stream PubMed, to step Curation: 001541
- to stream PubMed, to step Checkpoint: 001520
- to stream Ncbi, to step Merge: 002E76
- to stream Ncbi, to step Curation: 002E76
- to stream Ncbi, to step Checkpoint: 002E76
- to stream Main, to step Merge: 001D48
- to stream PascalFrancis, to step Corpus: 000823
- to stream PascalFrancis, to step Curation: 002496
- to stream PascalFrancis, to step Checkpoint: 000754
- to stream Main, to step Merge: 002341
- to stream Main, to step Curation: 001912
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?</title>
<author><name sortKey="Gallagher, David A" sort="Gallagher, David A" uniqKey="Gallagher D" first="David A." last="Gallagher">David A. Gallagher</name>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation><country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A82F4A012593B2A471D6228AB0751DEE51F91DC2</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23394</idno>
<idno type="url">https://api.istex.fr/document/A82F4A012593B2A471D6228AB0751DEE51F91DC2/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000536</idno>
<idno type="wicri:Area/Istex/Curation">000536</idno>
<idno type="wicri:Area/Istex/Checkpoint">000591</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Gallagher D:what:are:the</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20922807</idno>
<idno type="wicri:Area/PubMed/Corpus">001541</idno>
<idno type="wicri:Area/PubMed/Curation">001541</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001520</idno>
<idno type="wicri:Area/Ncbi/Merge">002E76</idno>
<idno type="wicri:Area/Ncbi/Curation">002E76</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002E76</idno>
<idno type="wicri:Area/Main/Merge">001D48</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0512921</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000823</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002496</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000754</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Gallagher D:what:are:the</idno>
<idno type="wicri:Area/Main/Merge">002341</idno>
<idno type="wicri:Area/Main/Curation">001912</idno>
<idno type="wicri:Area/Main/Exploration">001912</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?</title>
<author><name sortKey="Gallagher, David A" sort="Gallagher, David A" uniqKey="Gallagher D" first="David A." last="Gallagher">David A. Gallagher</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, Institute of Neurology, Royal Free Campus, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea>
<wicri:noRegion>University College London</wicri:noRegion>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuroscience, Institute of Neurology, Royal Free Campus, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-11-15">2010-11-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">15</biblScope>
<biblScope unit="page" from="2493">2493</biblScope>
<biblScope unit="page" to="2500">2500</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A82F4A012593B2A471D6228AB0751DEE51F91DC2</idno>
<idno type="DOI">10.1002/mds.23394</idno>
<idno type="ArticleID">MDS23394</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Autonomic Nervous System Diseases (complications)</term>
<term>Depression</term>
<term>Depression (complications)</term>
<term>Fatigue (complications)</term>
<term>Female</term>
<term>Health Surveys</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Quality of Life</term>
<term>Quality of life</term>
<term>Questionnaires</term>
<term>Severity of Illness Index</term>
<term>Sleep Disorders (complications)</term>
<term>autonomic</term>
<term>depression</term>
<term>quality of Life</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Depression</term>
<term>Fatigue</term>
<term>Parkinson Disease</term>
<term>Sleep Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Health Surveys</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Questionnaires</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term>
<term>Homme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Qualité de vie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Nonmotor symptoms (NMS) are increasingly recognized as important and neglected aspects of Parkinson's disease (PD). We evaluated their relative frequency and comparative impact on health‐related quality of life (Hr‐QoL) using validated questionnaires. In addition, we assessed the rate of reporting of NMS in neurology clinics compared with their subjective impact on patients. We used a range of validated clinimetric scales of motor and nonmotor symptoms and Hr‐QoL to assess consecutive patients with PD. Reporting of NMS was assessed by comparison with case note documentation. A mean of 11 of 30 NMS per patient were elicited on the NMS questionnaire of which on average 4.8 were reported in the clinical notes (44%). The most common NMS were autonomic (particularly urinary). The Hr‐QoL scores correlated most strongly with autonomic dysfunction (r = 0.84; particularly urinary and gastrointestinal symptoms), mood (r = 0.74), fatigue (r = 0.74), sleep problems (nocturnal r = 0.55; daytime somnolence r = 0.65), pain (r = 0.56), and psychosis (r = 0.55, all p < 0.0001) followed by UPDRS motor score (r = 0.48, p < 0.0001). Greater motor fluctuations (r = 0.57) and dyskinesia (r = 0.43, both p < 0.0001) were also associated with worse Hr‐QoL. In multivariate analysis, depression had the strongest association with Hr‐QoL (adjusted R2 = 0.53, p = 0.005) followed by fatigue, thermoregulatory, gastrointestinal, and cardiovascular autonomic function (especially orthostatic hypotension), daytime somnolence, and urinary problems. This study demonstrates that a autonomic dysfunction, psychiatric complications, pain, fatigue, and sleep problems are major correlates of poor Hr‐QoL. However, whilst psychiatric problems are increasingly documented, many symptoms (particularly those possibly perceived as embarrassing or unrelated) remain under‐reported. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gallagher, David A" sort="Gallagher, David A" uniqKey="Gallagher D" first="David A." last="Gallagher">David A. Gallagher</name>
</region>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001912 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001912 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:A82F4A012593B2A471D6228AB0751DEE51F91DC2 |texte= What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? }}
This area was generated with Dilib version V0.6.23. |