Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients
Identifieur interne : 003A43 ( Main/Exploration ); précédent : 003A42; suivant : 003A44Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients
Auteurs : Yoshihiro Sato [Japon] ; Yoshiaki Honda [Japon] ; Jun Iwamoto [Japon] ; Tomohiro Kanoko [Japon] ; Kei Satoh [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Bone Density (physiology), Bone Diseases, Metabolic (blood), Bone Diseases, Metabolic (etiology), Calcium, Calcium (metabolism), Case-Control Studies, Female, Human, Humans, Hypercalcemia, Immobilization, Inorganic element, Linear Models, Male, Metabolism, Middle Aged, Nervous system diseases, Parkinson Disease (blood), Parkinson Disease (complications), Parkinson disease, Retrospective Studies, Vitamin D, Vitamin D (analogs & derivatives), Vitamin D (blood), bone mineral density, hypercalcemia, immobilization, vitamin D.
- MESH :
- chemical , analogs & derivatives : Vitamin D.
- chemical , blood : Vitamin D.
- chemical , metabolism : Calcium.
- blood : Bone Diseases, Metabolic, Parkinson Disease.
- complications : Parkinson Disease.
- etiology : Bone Diseases, Metabolic.
- physiology : Bone Density.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Immobilization, Linear Models, Male, Middle Aged, Retrospective Studies.
Abstract
To elucidate the influence of immobilization‐induced hypercalcemia on bone metabolism in Parkinson's disease (PD), we measured serum biochemical indexes and bone mineral density (BMD) in the second metacarpals of 142 elderly PD patients and 99 age‐matched healthy controls. Serum concentrations of 25‐hydroxyvitamin D (25‐OHD), 1,25‐dihydroxyvitamin D (1,25‐[OH]2D), ionized calcium, intact parathyroid hormone (PTH), and intact bone Gla protein (BGP) were measured. Urinary deoxypyridinoline (D‐Pyr) was also measured. Increased serum calcium levels (mean, 1.27 mmol/L) were observed in PD patients, and the levels correlated negatively with the Unified Parkinson's Disease Rating Scale III (UPDRS III), indicating the presence of immobilization‐induced bone resorption with resultant hypercalcemia. Decreased serum concentrations of 1,25‐[OH]2D (mean, 88.7 pmol/L) and 25‐OHD (mean, 29.7 nmol/L) were noted. Serum PTH was decreased (mean, 25.2 ng/L). Serum BGP was decreased while urinary D‐Pyr concentration elevated. A negative correlation was observed between 1,25‐[OH]2D levels and serum calcium or UPDRS III (P < 0.0001). In disabled PD patients, immobilization‐induced hypercalcemia may inhibit secretion of PTH, which in turn suppresses 1,25‐[OH]2D production. 25‐OHD insufficiency may also contribute to decreased 1,25‐[OH]2D. These abnormalities may be corrected by the suppression of bone resorption with bisphoshonate, and supplementations of calcium and vitamin D should be avoided in these patients. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20658
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001991
- to stream Istex, to step Curation: 001991
- to stream Istex, to step Checkpoint: 002453
- to stream PubMed, to step Corpus: 002F05
- to stream PubMed, to step Curation: 002F05
- to stream PubMed, to step Checkpoint: 003255
- to stream Ncbi, to step Merge: 001407
- to stream Ncbi, to step Curation: 001407
- to stream Ncbi, to step Checkpoint: 001407
- to stream Main, to step Merge: 005130
- to stream PascalFrancis, to step Corpus: 001C33
- to stream PascalFrancis, to step Curation: 001088
- to stream PascalFrancis, to step Checkpoint: 001F50
- to stream Main, to step Merge: 005428
- to stream Main, to step Curation: 003A43
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients</title><author><name sortKey="Sato, Yoshihiro" sort="Sato, Yoshihiro" uniqKey="Sato Y" first="Yoshihiro" last="Sato">Yoshihiro Sato</name></author><author><name sortKey="Honda, Yoshiaki" sort="Honda, Yoshiaki" uniqKey="Honda Y" first="Yoshiaki" last="Honda">Yoshiaki Honda</name></author><author><name sortKey="Iwamoto, Jun" sort="Iwamoto, Jun" uniqKey="Iwamoto J" first="Jun" last="Iwamoto">Jun Iwamoto</name></author><author><name sortKey="Kanoko, Tomohiro" sort="Kanoko, Tomohiro" uniqKey="Kanoko T" first="Tomohiro" last="Kanoko">Tomohiro Kanoko</name></author><author><name sortKey="Satoh, Kei" sort="Satoh, Kei" uniqKey="Satoh K" first="Kei" last="Satoh">Kei Satoh</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9F165FED3C3A3AD3BCF95F1DDF752BD40DF5A498</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20658</idno><idno type="url">https://api.istex.fr/document/9F165FED3C3A3AD3BCF95F1DDF752BD40DF5A498/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001991</idno><idno type="wicri:Area/Istex/Curation">001991</idno><idno type="wicri:Area/Istex/Checkpoint">002453</idno><idno type="wicri:doubleKey">0885-3185:2005:Sato Y:abnormal:bone:and</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16114020</idno><idno type="wicri:Area/PubMed/Corpus">002F05</idno><idno type="wicri:Area/PubMed/Curation">002F05</idno><idno type="wicri:Area/PubMed/Checkpoint">003255</idno><idno type="wicri:Area/Ncbi/Merge">001407</idno><idno type="wicri:Area/Ncbi/Curation">001407</idno><idno type="wicri:Area/Ncbi/Checkpoint">001407</idno><idno type="wicri:doubleKey">0885-3185:2005:Sato Y:abnormal:bone:and</idno><idno type="wicri:Area/Main/Merge">005130</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:06-0191526</idno><idno type="wicri:Area/PascalFrancis/Corpus">001C33</idno><idno type="wicri:Area/PascalFrancis/Curation">001088</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001F50</idno><idno type="wicri:doubleKey">0885-3185:2005:Sato Y:abnormal:bone:and</idno><idno type="wicri:Area/Main/Merge">005428</idno><idno type="wicri:Area/Main/Curation">003A43</idno><idno type="wicri:Area/Main/Exploration">003A43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients</title><author><name sortKey="Sato, Yoshihiro" sort="Sato, Yoshihiro" uniqKey="Sato Y" first="Yoshihiro" last="Sato">Yoshihiro Sato</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Mitate Hospital, Tagawa</wicri:regionArea><wicri:noRegion>Tagawa</wicri:noRegion></affiliation></author><author><name sortKey="Honda, Yoshiaki" sort="Honda, Yoshiaki" uniqKey="Honda Y" first="Yoshiaki" last="Honda">Yoshiaki Honda</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Mitate Hospital, Tagawa</wicri:regionArea><wicri:noRegion>Tagawa</wicri:noRegion></affiliation></author><author><name sortKey="Iwamoto, Jun" sort="Iwamoto, Jun" uniqKey="Iwamoto J" first="Jun" last="Iwamoto">Jun Iwamoto</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Sports Medicine, School of Medicine Keiko University, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kanoko, Tomohiro" sort="Kanoko, Tomohiro" uniqKey="Kanoko T" first="Tomohiro" last="Kanoko">Tomohiro Kanoko</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rehabilitation Medicine, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea><wicri:noRegion>Hirosaki</wicri:noRegion></affiliation></author><author><name sortKey="Satoh, Kei" sort="Satoh, Kei" uniqKey="Satoh K" first="Kei" last="Satoh">Kei Satoh</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki</wicri:regionArea><wicri:noRegion>Hirosaki</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1598">1598</biblScope><biblScope unit="page" to="1603">1603</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9F165FED3C3A3AD3BCF95F1DDF752BD40DF5A498</idno><idno type="DOI">10.1002/mds.20658</idno><idno type="ArticleID">MDS20658</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Bone Density (physiology)</term><term>Bone Diseases, Metabolic (blood)</term><term>Bone Diseases, Metabolic (etiology)</term><term>Calcium</term><term>Calcium (metabolism)</term><term>Case-Control Studies</term><term>Female</term><term>Human</term><term>Humans</term><term>Hypercalcemia</term><term>Immobilization</term><term>Inorganic element</term><term>Linear Models</term><term>Male</term><term>Metabolism</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Retrospective Studies</term><term>Vitamin D</term><term>Vitamin D (analogs & derivatives)</term><term>Vitamin D (blood)</term><term>bone mineral density</term><term>hypercalcemia</term><term>immobilization</term><term>vitamin D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Bone Diseases, Metabolic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Bone Diseases, Metabolic</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Density</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Immobilization</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Calcium</term><term>Elément minéral</term><term>Homme</term><term>Hypercalcémie</term><term>Immobilisation</term><term>Métabolisme</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Vitamine D</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Calcium</term><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To elucidate the influence of immobilization‐induced hypercalcemia on bone metabolism in Parkinson's disease (PD), we measured serum biochemical indexes and bone mineral density (BMD) in the second metacarpals of 142 elderly PD patients and 99 age‐matched healthy controls. Serum concentrations of 25‐hydroxyvitamin D (25‐OHD), 1,25‐dihydroxyvitamin D (1,25‐[OH]2D), ionized calcium, intact parathyroid hormone (PTH), and intact bone Gla protein (BGP) were measured. Urinary deoxypyridinoline (D‐Pyr) was also measured. Increased serum calcium levels (mean, 1.27 mmol/L) were observed in PD patients, and the levels correlated negatively with the Unified Parkinson's Disease Rating Scale III (UPDRS III), indicating the presence of immobilization‐induced bone resorption with resultant hypercalcemia. Decreased serum concentrations of 1,25‐[OH]2D (mean, 88.7 pmol/L) and 25‐OHD (mean, 29.7 nmol/L) were noted. Serum PTH was decreased (mean, 25.2 ng/L). Serum BGP was decreased while urinary D‐Pyr concentration elevated. A negative correlation was observed between 1,25‐[OH]2D levels and serum calcium or UPDRS III (P < 0.0001). In disabled PD patients, immobilization‐induced hypercalcemia may inhibit secretion of PTH, which in turn suppresses 1,25‐[OH]2D production. 25‐OHD insufficiency may also contribute to decreased 1,25‐[OH]2D. These abnormalities may be corrected by the suppression of bone resorption with bisphoshonate, and supplementations of calcium and vitamin D should be avoided in these patients. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Sato, Yoshihiro" sort="Sato, Yoshihiro" uniqKey="Sato Y" first="Yoshihiro" last="Sato">Yoshihiro Sato</name></noRegion><name sortKey="Honda, Yoshiaki" sort="Honda, Yoshiaki" uniqKey="Honda Y" first="Yoshiaki" last="Honda">Yoshiaki Honda</name><name sortKey="Iwamoto, Jun" sort="Iwamoto, Jun" uniqKey="Iwamoto J" first="Jun" last="Iwamoto">Jun Iwamoto</name><name sortKey="Kanoko, Tomohiro" sort="Kanoko, Tomohiro" uniqKey="Kanoko T" first="Tomohiro" last="Kanoko">Tomohiro Kanoko</name><name sortKey="Satoh, Kei" sort="Satoh, Kei" uniqKey="Satoh K" first="Kei" last="Satoh">Kei Satoh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003A43 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003A43 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9F165FED3C3A3AD3BCF95F1DDF752BD40DF5A498
|texte= Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients
}}
| This area was generated with Dilib version V0.6.23. |  |