Treatment of periodic limb movements in sleep with selegiline HCl
Identifieur interne : 004250 ( Main/Exploration ); précédent : 004249; suivant : 004251Treatment of periodic limb movements in sleep with selegiline HCl
Auteurs : Manavdeep Grewal [Canada] ; Raed Hawa [Canada] ; Colin Shapiro [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson agent, Chemotherapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Electrodiagnosis, Female, Follow-Up Studies, Human, Humans, Involuntary movement, Male, Middle Aged, PLMS, Polygraphy, Polysomnography, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (drug therapy), Selegiline, Selegiline (adverse effects), Selegiline (therapeutic use), Selegiline HCl, Sleep, Treatment, Treatment Outcome, periodic limb movements in sleep, polysomnography.
- MESH :
- chemical , adverse effects : Selegiline.
- diagnosis : Restless Legs Syndrome.
- drug therapy : Restless Legs Syndrome.
- chemical , therapeutic use : Selegiline.
- Adult, Aged, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Middle Aged, Polysomnography, Treatment Outcome.
Abstract
Thirty‐one patients undergoing treatment with selegiline HCl for periodic limb movements in sleep (PLMS) were examined with respect to specific sleep composition in a retrospective study. Pre‐ and post‐treatment overnight polysomnographs revealed a highly significant decrease in the number of PLMS per hour of total sleep time (P < 0.0005). The alerting effect associated with selegiline was not found to have significant effect on patients' sleep efficiency or sleep‐onset latency (P > 0.10). As controversy continues regarding the medicated treatment of PLMS, our findings with selegiline point to an alternative for clinicians to consider. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10082
Affiliations:
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Le document en format XML
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<term>Drug Administration Schedule</term>
<term>Electrodiagnosis</term>
<term>Female</term>
<term>Follow-Up Studies</term>
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<term>Middle Aged</term>
<term>PLMS</term>
<term>Polygraphy</term>
<term>Polysomnography</term>
<term>Restless Legs Syndrome (diagnosis)</term>
<term>Restless Legs Syndrome (drug therapy)</term>
<term>Selegiline</term>
<term>Selegiline (adverse effects)</term>
<term>Selegiline (therapeutic use)</term>
<term>Selegiline HCl</term>
<term>Sleep</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>periodic limb movements in sleep</term>
<term>polysomnography</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Selegiline</term>
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<term>Aged</term>
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<term>Drug Administration Schedule</term>
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<term>Follow-Up Studies</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Polysomnography</term>
<term>Treatment Outcome</term>
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<term>Chimiothérapie</term>
<term>Electrodiagnostic</term>
<term>Homme</term>
<term>Mouvement involontaire</term>
<term>Polygraphie</term>
<term>Sommeil</term>
<term>Sélégiline</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Thirty‐one patients undergoing treatment with selegiline HCl for periodic limb movements in sleep (PLMS) were examined with respect to specific sleep composition in a retrospective study. Pre‐ and post‐treatment overnight polysomnographs revealed a highly significant decrease in the number of PLMS per hour of total sleep time (P < 0.0005). The alerting effect associated with selegiline was not found to have significant effect on patients' sleep efficiency or sleep‐onset latency (P > 0.10). As controversy continues regarding the medicated treatment of PLMS, our findings with selegiline point to an alternative for clinicians to consider. © 2002 Movement Disorder Society</div>
</front>
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