Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single‐dose study
Identifieur interne : 005596 ( Main/Exploration ); précédent : 005595; suivant : 005597Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single‐dose study
Auteurs : Pahwa [États-Unis] ; J. Marjama [États-Unis] ; D. Mcguire [États-Unis] ; K. Lyons [États-Unis] ; F. Zwiebel [États-Unis] ; P. Silverstein [États-Unis] ; R. Ward [États-Unis] ; W. C. Koller [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-07.
English descriptors
- KwdEn :
- Administration, Oral, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (pharmacokinetics), Biological Availability, Carbidopa (administration & dosage), Carbidopa (pharmacokinetics), Carbidopa/levodopa, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Generic, Humans, Levodopa (administration & dosage), Levodopa (pharmacokinetics), Male, Metabolic Clearance Rate (physiology), Motor Skills (drug effects), Neurologic Examination (drug effects), Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson's disease, Pharmacokinetics, Therapeutic Equivalency.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , pharmacokinetics : Antiparkinson Agents, Carbidopa, Levodopa.
- blood : Parkinson Disease.
- drug effects : Motor Skills, Neurologic Examination.
- drug therapy : Parkinson Disease.
- physiology : Metabolic Clearance Rate.
- Administration, Oral, Aged, Biological Availability, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Humans, Male, Therapeutic Equivalency.
Abstract
We compared the pharmacokinetic and motor responses of Sinemet and Atamet (generic carbidopa/levodopa) in patients with Parkinson's disease. Thirty Parkinson's disease patients (10 previously untreated, 10 with early disease, and 10 with motor fluctuations/dyskinesia) participated in a single‐dose double‐blind study. Following administration of an equivalent oral dose of Sinemet and Atamet on two separate days, we compared the peak plasma concentration, time to peak plasma concentration, area under the curve, total motor score, tapping score, and walking time. The mean time to peak plasma concentration was 49 min with Sinemet and 47 min with Atamet, the mean peak plasma concentration was 1,273 ng/ml with Sinemet and 1,153 ng/ml with Atamet, and the mean area under the curve was 2,295 m̈g/ml/h with Sinemet and 2,330 m̈g/ml/h with Atamet. Similarly, there was no significant difference between total motor score, tapping score, of walking time. In this single‐dose study, there were no significant differences in pharmacokinetic and motor responses between Sinmet and Atamet.
Url:
DOI: 10.1002/mds.870110412
Affiliations:
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<term>Antiparkinson Agents (pharmacokinetics)</term>
<term>Biological Availability</term>
<term>Carbidopa (administration & dosage)</term>
<term>Carbidopa (pharmacokinetics)</term>
<term>Carbidopa/levodopa</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Administration Schedule</term>
<term>Drug Combinations</term>
<term>Female</term>
<term>Generic</term>
<term>Humans</term>
<term>Levodopa (administration & dosage)</term>
<term>Levodopa (pharmacokinetics)</term>
<term>Male</term>
<term>Metabolic Clearance Rate (physiology)</term>
<term>Motor Skills (drug effects)</term>
<term>Neurologic Examination (drug effects)</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson's disease</term>
<term>Pharmacokinetics</term>
<term>Therapeutic Equivalency</term>
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<term>Aged</term>
<term>Biological Availability</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Administration Schedule</term>
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<front><div type="abstract" xml:lang="en">We compared the pharmacokinetic and motor responses of Sinemet and Atamet (generic carbidopa/levodopa) in patients with Parkinson's disease. Thirty Parkinson's disease patients (10 previously untreated, 10 with early disease, and 10 with motor fluctuations/dyskinesia) participated in a single‐dose double‐blind study. Following administration of an equivalent oral dose of Sinemet and Atamet on two separate days, we compared the peak plasma concentration, time to peak plasma concentration, area under the curve, total motor score, tapping score, and walking time. The mean time to peak plasma concentration was 49 min with Sinemet and 47 min with Atamet, the mean peak plasma concentration was 1,273 ng/ml with Sinemet and 1,153 ng/ml with Atamet, and the mean area under the curve was 2,295 m̈g/ml/h with Sinemet and 2,330 m̈g/ml/h with Atamet. Similarly, there was no significant difference between total motor score, tapping score, of walking time. In this single‐dose study, there were no significant differences in pharmacokinetic and motor responses between Sinmet and Atamet.</div>
</front>
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<li>Minnesota</li>
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<name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name>
<name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name>
<name sortKey="Marjama, J" sort="Marjama, J" uniqKey="Marjama J" first="J." last="Marjama">J. Marjama</name>
<name sortKey="Mcguire, D" sort="Mcguire, D" uniqKey="Mcguire D" first="D." last="Mcguire">D. Mcguire</name>
<name sortKey="Silverstein, P" sort="Silverstein, P" uniqKey="Silverstein P" first="P." last="Silverstein">P. Silverstein</name>
<name sortKey="Ward, R" sort="Ward, R" uniqKey="Ward R" first="R." last="Ward">R. Ward</name>
<name sortKey="Zwiebel, F" sort="Zwiebel, F" uniqKey="Zwiebel F" first="F." last="Zwiebel">F. Zwiebel</name>
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