Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single‐dose study
Identifieur interne : 003A98 ( Istex/Checkpoint ); précédent : 003A97; suivant : 003A99Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single‐dose study
Auteurs : Pahwa [États-Unis] ; J. Marjama [États-Unis] ; D. Mcguire [États-Unis] ; K. Lyons [États-Unis] ; F. Zwiebel [États-Unis] ; P. Silverstein [États-Unis] ; R. Ward [États-Unis] ; W. C. Koller [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-07.
English descriptors
Abstract
We compared the pharmacokinetic and motor responses of Sinemet and Atamet (generic carbidopa/levodopa) in patients with Parkinson's disease. Thirty Parkinson's disease patients (10 previously untreated, 10 with early disease, and 10 with motor fluctuations/dyskinesia) participated in a single‐dose double‐blind study. Following administration of an equivalent oral dose of Sinemet and Atamet on two separate days, we compared the peak plasma concentration, time to peak plasma concentration, area under the curve, total motor score, tapping score, and walking time. The mean time to peak plasma concentration was 49 min with Sinemet and 47 min with Atamet, the mean peak plasma concentration was 1,273 ng/ml with Sinemet and 1,153 ng/ml with Atamet, and the mean area under the curve was 2,295 m̈g/ml/h with Sinemet and 2,330 m̈g/ml/h with Atamet. Similarly, there was no significant difference between total motor score, tapping score, of walking time. In this single‐dose study, there were no significant differences in pharmacokinetic and motor responses between Sinmet and Atamet.
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DOI: 10.1002/mds.870110412
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Silverstein</name></author><author><name sortKey="Ward, R" sort="Ward, R" uniqKey="Ward R" first="R." last="Ward">R. Ward</name></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. 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Marjama</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Department of Neurology, University of Kansas Medical Center, Kansas City</wicri:cityArea></affiliation></author><author><name sortKey="Mcguire, D" sort="Mcguire, D" uniqKey="Mcguire D" first="D." last="Mcguire">D. Mcguire</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Department of Neurology, University of Kansas Medical Center, Kansas City</wicri:cityArea></affiliation></author><author><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Department of Neurology, University of Kansas Medical Center, Kansas City</wicri:cityArea></affiliation></author><author><name sortKey="Zwiebel, F" sort="Zwiebel, F" uniqKey="Zwiebel F" first="F." last="Zwiebel">F. Zwiebel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>St. Louis Park, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Silverstein, P" sort="Silverstein, P" uniqKey="Silverstein P" first="P." last="Silverstein">P. 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Thirty Parkinson's disease patients (10 previously untreated, 10 with early disease, and 10 with motor fluctuations/dyskinesia) participated in a single‐dose double‐blind study. Following administration of an equivalent oral dose of Sinemet and Atamet on two separate days, we compared the peak plasma concentration, time to peak plasma concentration, area under the curve, total motor score, tapping score, and walking time. The mean time to peak plasma concentration was 49 min with Sinemet and 47 min with Atamet, the mean peak plasma concentration was 1,273 ng/ml with Sinemet and 1,153 ng/ml with Atamet, and the mean area under the curve was 2,295 m̈g/ml/h with Sinemet and 2,330 m̈g/ml/h with Atamet. Similarly, there was no significant difference between total motor score, tapping score, of walking time. In this single‐dose study, there were no significant differences in pharmacokinetic and motor responses between Sinmet and Atamet.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kansas</li><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Kansas"><name sortKey="Pahwa" sort="Pahwa" uniqKey="Pahwa" last="Pahwa">Pahwa</name></region><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><name sortKey="Lyons, K" sort="Lyons, K" uniqKey="Lyons K" first="K." last="Lyons">K. Lyons</name><name sortKey="Marjama, J" sort="Marjama, J" uniqKey="Marjama J" first="J." last="Marjama">J. Marjama</name><name sortKey="Mcguire, D" sort="Mcguire, D" uniqKey="Mcguire D" first="D." last="Mcguire">D. Mcguire</name><name sortKey="Silverstein, P" sort="Silverstein, P" uniqKey="Silverstein P" first="P." last="Silverstein">P. Silverstein</name><name sortKey="Ward, R" sort="Ward, R" uniqKey="Ward R" first="R." last="Ward">R. Ward</name><name sortKey="Zwiebel, F" sort="Zwiebel, F" uniqKey="Zwiebel F" first="F." last="Zwiebel">F. Zwiebel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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