Motor cortex activation in Parkinson's disease: Dissociation of electrocortical and peripheral measures of response generation
Identifieur interne : 004D10 ( Main/Exploration ); précédent : 004D09; suivant : 004D11Motor cortex activation in Parkinson's disease: Dissociation of electrocortical and peripheral measures of response generation
Auteurs : Peter Praamstra [Pays-Bas] ; Erik M. Plat [Pays-Bas] ; Antje S. Meyer [Pays-Bas] ; Martin W. I. M. Horstink [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 1999-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Blinking (physiology), Electrocorticography, Electroencephalography, Electromyography, Electromyography (methods), Evoked potential, Exploration, Female, Human, Humans, Male, Middle Aged, Motor Cortex (physiopathology), Motor cortex, Movement preparation, Movement‐related potentials, Neural Pathways (physiopathology), Noise (adverse effects), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Psychomotor Disorders (diagnosis), Reaction Time, Time Factors.
- MESH :
- adverse effects : Noise.
- diagnosis : Psychomotor Disorders.
- methods : Electromyography.
- physiology : Blinking.
- physiopathology : Motor Cortex, Neural Pathways, Parkinson Disease.
- Aged, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Time Factors.
Abstract
This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise‐compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal‐related and movement‐related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement‐related neural activity.
Url:
DOI: 10.1002/1531-8257(199909)14:5<790::AID-MDS1011>3.0.CO;2-A
Affiliations:
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Le document en format XML
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Plat</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Clinical Neurophysiology, University Hospital Nijmegen and Max Planck Institute for Psycholinguistics, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Meyer, Antje S" sort="Meyer, Antje S" uniqKey="Meyer A" first="Antje S." last="Meyer">Antje S. Meyer</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Max Planck Institute for Psycholinguistics, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Horstink, Martin W I M" sort="Horstink, Martin W I M" uniqKey="Horstink M" first="Martin W. I. M." last="Horstink">Martin W. I. M. Horstink</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Clinical Neurophysiology, University Hospital Nijmegen and Max Planck Institute for Psycholinguistics, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-09">1999-09</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="790">790</biblScope><biblScope unit="page" to="799">799</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">748AACA2FC8F25D57A3D53B4A2F588652A4A25C8</idno><idno type="DOI">10.1002/1531-8257(199909)14:5<790::AID-MDS1011>3.0.CO;2-A</idno><idno type="ArticleID">MDS1011</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blinking (physiology)</term><term>Electrocorticography</term><term>Electroencephalography</term><term>Electromyography</term><term>Electromyography (methods)</term><term>Evoked potential</term><term>Exploration</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor cortex</term><term>Movement preparation</term><term>Movement‐related potentials</term><term>Neural Pathways (physiopathology)</term><term>Noise (adverse effects)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Psychomotor Disorders (diagnosis)</term><term>Reaction Time</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Noise</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Electrocorticographie</term><term>Electromyographie</term><term>Exploration</term><term>Homme</term><term>Parkinson maladie</term><term>Potentiel évoqué</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise‐compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal‐related and movement‐related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement‐related neural activity.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Gueldre</li></region><settlement><li>Nimègue</li></settlement></list><tree><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Praamstra, Peter" sort="Praamstra, Peter" uniqKey="Praamstra P" first="Peter" last="Praamstra">Peter Praamstra</name></region><name sortKey="Horstink, Martin W I M" sort="Horstink, Martin W I M" uniqKey="Horstink M" first="Martin W. I. M." last="Horstink">Martin W. I. M. Horstink</name><name sortKey="Meyer, Antje S" sort="Meyer, Antje S" uniqKey="Meyer A" first="Antje S." last="Meyer">Antje S. Meyer</name><name sortKey="Plat, Erik M" sort="Plat, Erik M" uniqKey="Plat E" first="Erik M." last="Plat">Erik M. Plat</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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