Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.
Identifieur interne : 004174 ( PubMed/Checkpoint ); précédent : 004173; suivant : 004175Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.
Auteurs : P. Praamstra [Pays-Bas] ; E M Plat ; A S Meyer ; M W HorstinkSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Aged, Blinking (physiology), Electroencephalography, Electromyography (methods), Female, Humans, Male, Middle Aged, Motor Cortex (physiopathology), Neural Pathways (physiopathology), Noise (adverse effects), Parkinson Disease (physiopathology), Psychomotor Disorders (diagnosis), Reaction Time, Time Factors.
- MESH :
- adverse effects : Noise.
- diagnosis : Psychomotor Disorders.
- methods : Electromyography.
- physiology : Blinking.
- physiopathology : Motor Cortex, Neural Pathways, Parkinson Disease.
- Aged, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Time Factors.
Abstract
This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.
PubMed: 10495040
Affiliations:
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pubmed:10495040Le document en format XML
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Praamstra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Nijmegen</wicri:regionArea><wicri:noRegion>University Hospital Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Plat, E M" sort="Plat, E M" uniqKey="Plat E" first="E M" last="Plat">E M Plat</name></author><author><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A S" last="Meyer">A S Meyer</name></author><author><name sortKey="Horstink, M W" sort="Horstink, M W" uniqKey="Horstink M" first="M W" last="Horstink">M W Horstink</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10495040</idno><idno type="pmid">10495040</idno><idno type="wicri:Area/PubMed/Corpus">004129</idno><idno type="wicri:Area/PubMed/Curation">004129</idno><idno type="wicri:Area/PubMed/Checkpoint">004174</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.</title><author><name sortKey="Praamstra, P" sort="Praamstra, P" uniqKey="Praamstra P" first="P" last="Praamstra">P. Praamstra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Nijmegen</wicri:regionArea><wicri:noRegion>University Hospital Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Plat, E M" sort="Plat, E M" uniqKey="Plat E" first="E M" last="Plat">E M Plat</name></author><author><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A S" last="Meyer">A S Meyer</name></author><author><name sortKey="Horstink, M W" sort="Horstink, M W" uniqKey="Horstink M" first="M W" last="Horstink">M W Horstink</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blinking (physiology)</term><term>Electroencephalography</term><term>Electromyography (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Neural Pathways (physiopathology)</term><term>Noise (adverse effects)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Disorders (diagnosis)</term><term>Reaction Time</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Noise</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Neural Pathways</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10495040</PMID><DateCreated><Year>1999</Year><Month>11</Month><Day>10</Day></DateCreated><DateCompleted><Year>1999</Year><Month>11</Month><Day>10</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>5</Issue><PubDate><Year>1999</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.</ArticleTitle><Pagination><MedlinePgn>790-9</MedlinePgn></Pagination><Abstract><AbstractText>This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Praamstra</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Hospital Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plat</LastName><ForeName>E M</ForeName><Initials>EM</Initials></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>A S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Horstink</LastName><ForeName>M W</ForeName><Initials>MW</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001767">Blinking</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009434">Neural Pathways</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009622">Noise</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011596">Psychomotor Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>9</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>9</Month><Day>24</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>9</Month><Day>24</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10495040</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Horstink, M W" sort="Horstink, M W" uniqKey="Horstink M" first="M W" last="Horstink">M W Horstink</name><name sortKey="Meyer, A S" sort="Meyer, A S" uniqKey="Meyer A" first="A S" last="Meyer">A S Meyer</name><name sortKey="Plat, E M" sort="Plat, E M" uniqKey="Plat E" first="E M" last="Plat">E M Plat</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Praamstra, P" sort="Praamstra, P" uniqKey="Praamstra P" first="P" last="Praamstra">P. 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