MovDisordV3, Main, Exploration, bibRecord, 004561

Bilateral pallidotomy in Parkinson's disease: A retrospective study

Identifieur interne : 004561 ( Main/Exploration ); précédent : 004560; suivant : 004562

Bilateral pallidotomy in Parkinson's disease: A retrospective study

Auteurs : Rob M. A. De Bie [Pays-Bas] ; P. Richard Schuurman [Pays-Bas] ; Rianne A. J. Esselink [Pays-Bas] ; D. Andries Bosch [Pays-Bas] ; Johannes D. Speelman [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-05.

RBID : ISTEX:41A4282EC69713F12D51093444A78FA2453FCD68

Descripteurs français

Pascal (Inist)
- Activité, Adulte, Bilatéral, Complication, Exérèse, Handicap, Pallidum, Parkinson maladie, Pronostic, Rétrospective, Stade avancé, Traitement, Vie quotidienne.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Activity, Adult, Advanced stage, Bilateral, Complication, Daily living, Data Collection, Exeresis, Female, Follow-Up Studies, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Handicap, Humans, Male, Middle Aged, Pallidum, Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Prognosis, Retrospective, Retrospective Studies, Stereotaxic Techniques (adverse effects), Treatment, Treatment Outcome, clinical outcome, pallidotomy, stereotactic surgery.
MESH :
- adverse effects : Stereotaxic Techniques.
- physiopathology : Globus Pallidus, Parkinson Disease.
- surgery : Globus Pallidus, Parkinson Disease.
- Data Collection, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies, Treatment Outcome.

Abstract

We evaluated the effects of bilateral pallidotomy in patients with advanced Parkinson's disease. Thirteen patients with Parkinson's disease had a staged bilateral pallidotomy if they had severe response fluctuations, dyskinesias, painful dystonia, or bradykinesia despite optimum pharmacological treatment. Assessment scales were the Unified Parkinson's Disease Rating scale (UPDRS), the Schwab and England scale, and a questionnaire on the effects of disability in activities of daily living and adverse effects. Postoperative magnetic resonance imaging was evaluated for lesion location and extension. The median off‐phase UPDRS motor score was reduced from 43.5 to 29 after the first pallidotomy, and it was further reduced to 23.5 after the second pallidotomy (n = 8). The UPDRS activities of daily living off‐phase score improved from 28.5 to 20.5 after the first pallidotomy and to 19 after the second pallidotomy (n = 6). The Schwab and England scale off‐phase score showed an improvement after both procedures, first from 40 to 60, and thereafter to 90 (n = 8). On‐phase dyskinesias were reduced substantially. Eight patients had adverse effects, of whom five had problems with speech. One patient became hemiplegic due to a delayed infarction. Ten patients experienced further benefit from the second procedure. Bilateral pallidotomy reduces dyskinesias. A second contralateral pallidotomy may reduce parkinsonism, although to a lesser degree compared with the first pallidotomy and with an increased risk for adverse effects. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/41A4282EC69713F12D51093444A78FA2453FCD68/fulltext/pdf

DOI: 10.1002/mds.10090

Affiliations:

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<term>Data Collection</term>
<term>Exeresis</term>
<term>Female</term>
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<front><div type="abstract" xml:lang="en">We evaluated the effects of bilateral pallidotomy in patients with advanced Parkinson's disease. Thirteen patients with Parkinson's disease had a staged bilateral pallidotomy if they had severe response fluctuations, dyskinesias, painful dystonia, or bradykinesia despite optimum pharmacological treatment. Assessment scales were the Unified Parkinson's Disease Rating scale (UPDRS), the Schwab and England scale, and a questionnaire on the effects of disability in activities of daily living and adverse effects. Postoperative magnetic resonance imaging was evaluated for lesion location and extension. The median off‐phase UPDRS motor score was reduced from 43.5 to 29 after the first pallidotomy, and it was further reduced to 23.5 after the second pallidotomy (n = 8). The UPDRS activities of daily living off‐phase score improved from 28.5 to 20.5 after the first pallidotomy and to 19 after the second pallidotomy (n = 6). The Schwab and England scale off‐phase score showed an improvement after both procedures, first from 40 to 60, and thereafter to 90 (n = 8). On‐phase dyskinesias were reduced substantially. Eight patients had adverse effects, of whom five had problems with speech. One patient became hemiplegic due to a delayed infarction. Ten patients experienced further benefit from the second procedure. Bilateral pallidotomy reduces dyskinesias. A second contralateral pallidotomy may reduce parkinsonism, although to a lesser degree compared with the first pallidotomy and with an increased risk for adverse effects. © 2002 Movement Disorder Society</div>
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Movement Disorders (revue)

Bilateral pallidotomy in Parkinson's disease: A retrospective study

Bilateral pallidotomy in Parkinson's disease: A retrospective study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.