Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease
Identifieur interne : 004560 ( Main/Exploration ); précédent : 004559; suivant : 004561Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease
Auteurs : Pablo Martínez-Martín [Espagne] ; Francesc Valldeoriola [Espagne] ; Eduardo Tolosa [Espagne] ; Manuela Pilleri [Espagne] ; José Luis Molinuevo [Espagne] ; Jordi Rumià [Espagne] ; Enric Ferrer [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-03.
English descriptors
Abstract
We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health‐related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 ± 7.7 years [range, 43–74 years]; disease duration, 16.4 ± 8.5 years [range, 7–38 years]; mean off‐medication Hoehn and Yahr stage, 4.23 ± 0.66 [range, 2.5–5]). Each patient's assessment was carried out using common rating scales, following the Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ‐39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ‐39 Summary Index (PDQ‐39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well‐being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ‐39SI) and in the other variables. As measured by the PDQ‐39, STN‐DBS significantly improves important aspects of QoL in patients with advanced PD. © 2002 Movement Disorder Society.
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DOI: 10.1002/mds.10044
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="372">372</biblScope><biblScope unit="page" to="377">377</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">880A47F1D9CBD9721DF6997A37B1024B25A41954</idno><idno type="DOI">10.1002/mds.10044</idno><idno type="ArticleID">MDS10044</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PDQ‐39</term><term>Parkinson's disease</term><term>quality of life</term><term>subthalamic stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health‐related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 ± 7.7 years [range, 43–74 years]; disease duration, 16.4 ± 8.5 years [range, 7–38 years]; mean off‐medication Hoehn and Yahr stage, 4.23 ± 0.66 [range, 2.5–5]). Each patient's assessment was carried out using common rating scales, following the Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ‐39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ‐39 Summary Index (PDQ‐39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well‐being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ‐39SI) and in the other variables. As measured by the PDQ‐39, STN‐DBS significantly improves important aspects of QoL in patients with advanced PD. © 2002 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Artin, Pablo" sort="Martinez Artin, Pablo" uniqKey="Martinez Artin P" first="Pablo" last="Martínez-Martín">Pablo Martínez-Martín</name></region><name sortKey="Ferrer, Enric" sort="Ferrer, Enric" uniqKey="Ferrer E" first="Enric" last="Ferrer">Enric Ferrer</name><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name><name sortKey="Pilleri, Manuela" sort="Pilleri, Manuela" uniqKey="Pilleri M" first="Manuela" last="Pilleri">Manuela Pilleri</name><name sortKey="Rumia, Jordi" sort="Rumia, Jordi" uniqKey="Rumia J" first="Jordi" last="Rumià">Jordi Rumià</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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