MovDisordV3, Main, Exploration, bibRecord, 004484

Effect of medication on EMG patterns in individuals with Parkinson's disease

Identifieur interne : 004484 ( Main/Exploration ); précédent : 004483; suivant : 004485

Effect of medication on EMG patterns in individuals with Parkinson's disease

Auteurs : Julie A. Robichaud [États-Unis] ; Kerstin D. Pfann [États-Unis] ; Cynthia L. Comella [États-Unis] ; Daniel M. Corcos [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-09.

RBID : ISTEX:915FB92AA301FDE6D0E2075B8CA207A1DC9EB778

Descripteurs français

Pascal (Inist)
- Antiparkinsonien, Chimiothérapie, Electromyographie, Exploration, Homme, Mouvement, Parkinson maladie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Antiparkinson agent, Chemotherapy, EMG patterns, Electromyography, Electromyography (drug effects), Exploration, Female, Human, Humans, Male, Middle Aged, Motion, Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Time Factors, medication, movement control.
MESH :
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug effects : Electromyography.
- drug therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Time Factors.

Abstract

Individuals with Parkinson's disease show dramatic improvements in their ability to move when medicated. However, the neural cause of this improvement is unclear. One hypothesis is that neural activation patterns, as measured by surface electromyography (EMG), are normalized by medication. We tested this hypothesis by investigating the effect of medication on the electromyographic (EMG) patterns recorded when individuals with idiopathic Parkinson's disease performed elbow flexion movements over three movement distances while off and on antiparkinsonian medication. When the subjects were off medication, they lacked the ability to modulate the agonist EMG burst duration with changes in movement distance. The ability to modulate agonist EMG burst duration is characteristic of the EMG patterns observed in healthy subjects. Also, multiple agonist bursts were exhibited during the acceleration phase. As expected, medication diminished the clinical signs of Parkinson's disease, increased movement speed, and increased the magnitude of the first agonist burst. Medication did not restore agonist burst duration modulation with movement distance, did not change the frequency of agonist bursting, and did not alter the timing of the antagonist activation. These results show that medication does not alter the temporal profile of EMG activation. © 2002 Movement Disorder Society

Url:

https://api.istex.fr/document/915FB92AA301FDE6D0E2075B8CA207A1DC9EB778/fulltext/pdf

DOI: 10.1002/mds.10218

Affiliations:

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<front><div type="abstract" xml:lang="en">Individuals with Parkinson's disease show dramatic improvements in their ability to move when medicated. However, the neural cause of this improvement is unclear. One hypothesis is that neural activation patterns, as measured by surface electromyography (EMG), are normalized by medication. We tested this hypothesis by investigating the effect of medication on the electromyographic (EMG) patterns recorded when individuals with idiopathic Parkinson's disease performed elbow flexion movements over three movement distances while off and on antiparkinsonian medication. When the subjects were off medication, they lacked the ability to modulate the agonist EMG burst duration with changes in movement distance. The ability to modulate agonist EMG burst duration is characteristic of the EMG patterns observed in healthy subjects. Also, multiple agonist bursts were exhibited during the acceleration phase. As expected, medication diminished the clinical signs of Parkinson's disease, increased movement speed, and increased the magnitude of the first agonist burst. Medication did not restore agonist burst duration modulation with movement distance, did not change the frequency of agonist bursting, and did not alter the timing of the antagonist activation. These results show that medication does not alter the temporal profile of EMG activation. © 2002 Movement Disorder Society</div>
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Movement Disorders (revue)

Effect of medication on EMG patterns in individuals with Parkinson's disease

Effect of medication on EMG patterns in individuals with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.