Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?
Identifieur interne : 003B87 ( Main/Exploration ); précédent : 003B86; suivant : 003B88Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?
Auteurs : Rainer Linke [Allemagne] ; Ilonka Eisensehr [Allemagne] ; Thomas-Christian Wetter [Allemagne] ; Franz-Josef Gildehaus [Allemagne] ; Gabriele Pöpperl [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Soheyl Noachtar [Allemagne] ; Klaus Tatsch [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Corpus Striatum (metabolism), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), DAT, Diagnosis, Differential, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Female, Functional Laterality (physiology), Human, Humans, Male, Membrane Glycoproteins (metabolism), Membrane Transport Proteins (metabolism), Middle Aged, Nerve Tissue Proteins (metabolism), Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Presynaptic, Putamen (metabolism), Putamen (physiopathology), Putamen (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Receptors, Presynaptic (metabolism), Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (metabolism), Restless Legs Syndrome (physiopathology), Restless legs syndrome, Tomography, Emission-Computed, Single-Photon, dopamine transporter SPECT, restless legs syndrome.
- MESH :
- chemical , diagnostic use : Radiopharmaceuticals.
- chemical , metabolism : Dopamine, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Presynaptic.
- diagnosis : Parkinson Disease, Restless Legs Syndrome.
- metabolism : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- physiology : Functional Laterality.
- physiopathology : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- radionuclide imaging : Corpus Striatum, Putamen.
- Aged, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20226
Affiliations:
- Allemagne
- Bavière, District de Haute-Bavière, District de Kassel, Hesse (Land)
- Cassel (Hesse), Munich
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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<term>Corpus Striatum (physiopathology)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>DAT</term>
<term>Diagnosis, Differential</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Membrane Transport Proteins (metabolism)</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins (metabolism)</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Presynaptic</term>
<term>Putamen (metabolism)</term>
<term>Putamen (physiopathology)</term>
<term>Putamen (radionuclide imaging)</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>Receptors, Presynaptic (metabolism)</term>
<term>Restless Legs Syndrome (diagnosis)</term>
<term>Restless Legs Syndrome (metabolism)</term>
<term>Restless Legs Syndrome (physiopathology)</term>
<term>Restless legs syndrome</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>dopamine transporter SPECT</term>
<term>restless legs syndrome</term>
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<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Nerve Tissue Proteins</term>
<term>Receptors, Presynaptic</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
<term>Restless Legs Syndrome</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
<term>Restless Legs Syndrome</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
<term>Restless Legs Syndrome</term>
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<term>Diagnosis, Differential</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
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<term>Humans</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Impatience membre inférieur syndrome</term>
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<front><div type="abstract" xml:lang="en">The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society</div>
</front>
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<li>District de Haute-Bavière</li>
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<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Linke, Rainer" sort="Linke, Rainer" uniqKey="Linke R" first="Rainer" last="Linke">Rainer Linke</name>
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<name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name>
<name sortKey="Gildehaus, Franz Osef" sort="Gildehaus, Franz Osef" uniqKey="Gildehaus F" first="Franz-Josef" last="Gildehaus">Franz-Josef Gildehaus</name>
<name sortKey="Noachtar, Soheyl" sort="Noachtar, Soheyl" uniqKey="Noachtar S" first="Soheyl" last="Noachtar">Soheyl Noachtar</name>
<name sortKey="Popperl, Gabriele" sort="Popperl, Gabriele" uniqKey="Popperl G" first="Gabriele" last="Pöpperl">Gabriele Pöpperl</name>
<name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
<name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name>
<name sortKey="Wetter, Thomas Hristian" sort="Wetter, Thomas Hristian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name>
</country>
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