Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?
Identifieur interne : 005545 ( Main/Merge ); précédent : 005544; suivant : 005546Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?
Auteurs : Rainer Linke [Allemagne] ; Ilonka Eisensehr [Allemagne] ; Thomas-Christian Wetter [Allemagne] ; Franz-Josef Gildehaus [Allemagne] ; Gabriele Pöpperl [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Soheyl Noachtar [Allemagne] ; Klaus Tatsch [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
English descriptors
- KwdEn :
- Aged, Corpus Striatum (metabolism), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), DAT, Diagnosis, Differential, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Female, Functional Laterality (physiology), Humans, Male, Membrane Glycoproteins (metabolism), Membrane Transport Proteins (metabolism), Middle Aged, Nerve Tissue Proteins (metabolism), Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson's disease, Putamen (metabolism), Putamen (physiopathology), Putamen (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Receptors, Presynaptic (metabolism), Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (metabolism), Restless Legs Syndrome (physiopathology), Tomography, Emission-Computed, Single-Photon, dopamine transporter SPECT, restless legs syndrome.
- MESH :
- chemical , diagnostic use : Radiopharmaceuticals.
- chemical , metabolism : Dopamine, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Presynaptic.
- diagnosis : Parkinson Disease, Restless Legs Syndrome.
- metabolism : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- physiology : Functional Laterality.
- physiopathology : Corpus Striatum, Parkinson Disease, Putamen, Restless Legs Syndrome.
- radionuclide imaging : Corpus Striatum, Putamen.
- Aged, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20226
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nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1158">1158</biblScope><biblScope unit="page" to="1162">1162</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8B66BCA42FF5756E7A7EC5A911A52B0B1C609631</idno><idno type="DOI">10.1002/mds.20226</idno><idno type="ArticleID">MDS20226</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (physiopathology)</term><term>Corpus Striatum (radionuclide imaging)</term><term>DAT</term><term>Diagnosis, Differential</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins (metabolism)</term><term>Membrane Transport Proteins (metabolism)</term><term>Middle Aged</term><term>Nerve Tissue Proteins (metabolism)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson's disease</term><term>Putamen (metabolism)</term><term>Putamen (physiopathology)</term><term>Putamen (radionuclide imaging)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Receptors, Presynaptic (metabolism)</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (metabolism)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>dopamine transporter SPECT</term><term>restless legs syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Putamen</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Putamen</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20226"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?</title><author><name sortKey="Linke, Rainer" sort="Linke, Rainer" uniqKey="Linke R" first="Rainer" last="Linke">Rainer Linke</name></author><author><name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name></author><author><name sortKey="Wetter, Thomas Hristian" sort="Wetter, Thomas Hristian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name></author><author><name sortKey="Gildehaus, Franz Osef" sort="Gildehaus, Franz Osef" uniqKey="Gildehaus F" first="Franz-Josef" last="Gildehaus">Franz-Josef Gildehaus</name></author><author><name sortKey="Popperl, Gabriele" sort="Popperl, Gabriele" uniqKey="Popperl G" first="Gabriele" last="Pöpperl">Gabriele Pöpperl</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Noachtar, Soheyl" sort="Noachtar, Soheyl" uniqKey="Noachtar S" first="Soheyl" last="Noachtar">Soheyl Noachtar</name></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8B66BCA42FF5756E7A7EC5A911A52B0B1C609631</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/mds.20226</idno><idno type="url">https://api.istex.fr/document/8B66BCA42FF5756E7A7EC5A911A52B0B1C609631/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002919</idno><idno type="wicri:Area/Istex/Curation">002919</idno><idno type="wicri:Area/Istex/Checkpoint">002568</idno><idno type="wicri:doubleKey">0885-3185:2004:Linke R:presynaptic:dopaminergic:function</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Presynaptic dopaminergic function in patients with restless legs syndrome: Are there common features with early Parkinson's disease?</title><author><name sortKey="Linke, Rainer" sort="Linke, Rainer" uniqKey="Linke R" first="Rainer" last="Linke">Rainer Linke</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Wetter, Thomas Hristian" sort="Wetter, Thomas Hristian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Gildehaus, Franz Osef" sort="Gildehaus, Franz Osef" uniqKey="Gildehaus F" first="Franz-Josef" last="Gildehaus">Franz-Josef Gildehaus</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Popperl, Gabriele" sort="Popperl, Gabriele" uniqKey="Popperl G" first="Gabriele" last="Pöpperl">Gabriele Pöpperl</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Current Address: Paracelsus‐Elena‐Klinik, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Noachtar, Soheyl" sort="Noachtar, Soheyl" uniqKey="Noachtar S" first="Soheyl" last="Noachtar">Soheyl Noachtar</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1158">1158</biblScope><biblScope unit="page" to="1162">1162</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8B66BCA42FF5756E7A7EC5A911A52B0B1C609631</idno><idno type="DOI">10.1002/mds.20226</idno><idno type="ArticleID">MDS20226</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DAT</term><term>Parkinson's disease</term><term>dopamine transporter SPECT</term><term>restless legs syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [123I] N‐(3‐iodopropen‐2‐yl)‐2β‐carbomethoxy‐3β‐(chloro‐phenyl) tropane ([123I]IPT) and single‐photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age‐matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi‐ and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function. © 2004 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Presynaptic dopaminergic function in patients with restless legs syndrome: are there common features with early Parkinson's disease?</title><author><name sortKey="Linke, Rainer" sort="Linke, Rainer" uniqKey="Linke R" first="Rainer" last="Linke">Rainer Linke</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, University of Munich, Munich, Germany. rainer.linke@med.uni-muenchen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name></author><author><name sortKey="Wetter, Thomas Christian" sort="Wetter, Thomas Christian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name></author><author><name sortKey="Gildehaus, Franz Josef" sort="Gildehaus, Franz Josef" uniqKey="Gildehaus F" first="Franz-Josef" last="Gildehaus">Franz-Josef Gildehaus</name></author><author><name sortKey="Popperl, Gabriele" sort="Popperl, Gabriele" uniqKey="Popperl G" first="Gabriele" last="Pöpperl">Gabriele Pöpperl</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Noachtar, Soheyl" sort="Noachtar, Soheyl" uniqKey="Noachtar S" first="Soheyl" last="Noachtar">Soheyl Noachtar</name></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15390076</idno><idno type="pmid">15390076</idno><idno type="doi">10.1002/mds.20226</idno><idno type="wicri:Area/PubMed/Corpus">003237</idno><idno type="wicri:Area/PubMed/Curation">003237</idno><idno type="wicri:Area/PubMed/Checkpoint">003358</idno><idno type="wicri:Area/Ncbi/Merge">001051</idno><idno type="wicri:Area/Ncbi/Curation">001051</idno><idno type="wicri:Area/Ncbi/Checkpoint">001051</idno><idno type="wicri:doubleKey">0885-3185:2004:Linke R:presynaptic:dopaminergic:function</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Presynaptic dopaminergic function in patients with restless legs syndrome: are there common features with early Parkinson's disease?</title><author><name sortKey="Linke, Rainer" sort="Linke, Rainer" uniqKey="Linke R" first="Rainer" last="Linke">Rainer Linke</name><affiliation wicri:level="4"><nlm:affiliation>Department of Nuclear Medicine, University of Munich, Munich, Germany. rainer.linke@med.uni-muenchen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nuclear Medicine, University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Eisensehr, Ilonka" sort="Eisensehr, Ilonka" uniqKey="Eisensehr I" first="Ilonka" last="Eisensehr">Ilonka Eisensehr</name></author><author><name sortKey="Wetter, Thomas Christian" sort="Wetter, Thomas Christian" uniqKey="Wetter T" first="Thomas-Christian" last="Wetter">Thomas-Christian Wetter</name></author><author><name sortKey="Gildehaus, Franz Josef" sort="Gildehaus, Franz Josef" uniqKey="Gildehaus F" first="Franz-Josef" last="Gildehaus">Franz-Josef Gildehaus</name></author><author><name sortKey="Popperl, Gabriele" sort="Popperl, Gabriele" uniqKey="Popperl G" first="Gabriele" last="Pöpperl">Gabriele Pöpperl</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Noachtar, Soheyl" sort="Noachtar, Soheyl" uniqKey="Noachtar S" first="Soheyl" last="Noachtar">Soheyl Noachtar</name></author><author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (physiopathology)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins (metabolism)</term><term>Membrane Transport Proteins (metabolism)</term><term>Middle Aged</term><term>Nerve Tissue Proteins (metabolism)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (physiopathology)</term><term>Putamen (metabolism)</term><term>Putamen (physiopathology)</term><term>Putamen (radionuclide imaging)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Receptors, Presynaptic (metabolism)</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (metabolism)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Putamen</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Putamen</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cause of restless legs syndrome (RLS) is unknown, but an involvement of the dopaminergic system and a possible relation to Parkinson's disease (PD) is suggested by the positive response to dopaminergic treatment. We imaged the striatal dopamine transporter with [(123)I] N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(chloro-phenyl) tropane ([(123)I]IPT) and single-photon emission computed tomography (SPECT) in 28 RLS patients, and compared the results with transporter binding in 29 patients with early PD and 23 age-matched controls. No difference in IPT binding was found between RLS patients and controls. IPT binding was correlated significantly with age in RLS patients and controls, whereas there was no relation with the duration of symptoms or severity of RLS. PD patients presented significant lower presynaptic IPT binding ipsi- and contralateral to the affected body side compared with RLS patients or controls. We found no common characteristics between RLS patients and patients with early PD detectable by dopamine transporter SPECT. Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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