Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism
Identifieur interne : 003A58 ( Main/Exploration ); précédent : 003A57; suivant : 003A59Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism
Auteurs : Antonio L. Jr Teixeira [Brésil] ; Melissa M. Guimaraes [Brésil] ; Marco Aurélio Romano-Silva [Brésil] ; Francisco Cardoso [Brésil]Source :
- Movement disorders [ 0885-3185 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism</title>
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<author><name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimaraes">Melissa M. Guimaraes</name>
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<author><name sortKey="Romano Silva, Marco Aurelio" sort="Romano Silva, Marco Aurelio" uniqKey="Romano Silva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
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<author><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
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<s3>BRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<placeName><settlement type="city">Belo Horizonte</settlement>
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<series><title level="j" type="main">Movement disorders</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term>
<term>Calcium</term>
<term>Complement</term>
<term>Human</term>
<term>Intracellular</term>
<term>Nervous system diseases</term>
<term>Streptococcal infection</term>
<term>Streptococcus</term>
<term>Sydenham chorea</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée Sydenham</term>
<term>Streptococcie</term>
<term>Homme</term>
<term>Intracellulaire</term>
<term>Calcium</term>
<term>Complément</term>
<term>Noyau gris central</term>
<term>Streptococcus</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Calcium</term>
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<front><div type="abstract" xml:lang="en">The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca<sup>2+</sup>
levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca<sup>2+</sup>
levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
</country>
<region><li>Minas Gerais</li>
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<settlement><li>Belo Horizonte</li>
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<orgName><li>Université fédérale du Minas Gerais</li>
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<tree><country name="Brésil"><region name="Minas Gerais"><name sortKey="Teixeira, Antonio L Jr" sort="Teixeira, Antonio L Jr" uniqKey="Teixeira A" first="Antonio L. Jr" last="Teixeira">Antonio L. Jr Teixeira</name>
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<name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
<name sortKey="Guimaraes, Melissa M" sort="Guimaraes, Melissa M" uniqKey="Guimaraes M" first="Melissa M." last="Guimaraes">Melissa M. Guimaraes</name>
<name sortKey="Romano Silva, Marco Aurelio" sort="Romano Silva, Marco Aurelio" uniqKey="Romano Silva M" first="Marco Aurélio" last="Romano-Silva">Marco Aurélio Romano-Silva</name>
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</record>
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