Asymmetric corticomotor excitability correlations in early Parkinson's disease
Identifieur interne : 003008 ( Main/Exploration ); précédent : 003007; suivant : 003009Asymmetric corticomotor excitability correlations in early Parkinson's disease
Auteurs : Allan D. Wu [États-Unis] ; Giselle M. Petzinger [États-Unis] ; Chien-Ho J. Lin [États-Unis] ; Myron Kung [États-Unis] ; Beth Fisher [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Radiation, Electric Stimulation (methods), Evoked Potentials, Motor (physiology), Excitability, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Motor Cortex (physiopathology), Motor evoked potential, Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Silent period, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, cortical excitability, motor evoked potentials, silent period, transcranial magnetic stimulation..
- MESH :
- diagnosis : Parkinson Disease.
- methods : Electric Stimulation.
- physiology : Evoked Potentials, Motor.
- physiopathology : Motor Cortex, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Radiation, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
We studied corticomotor excitability (CE) between the more and less affected sides in early Parkinson's disease (PD) patients using transcranial magnetic stimulation (TMS). Sixteen‐PD patients within the first 3 years of diagnosis were studied with single‐pulse TMS over each motor cortex with intensities from 40% to 100% stimulator output. Active motor evoked potentials (MEP) and cortical silent period durations (CSP) were recorded, fitted with sigmoid curves, summarized as maximal MEP/CSP, maximal MEP/CSP slope, and intensity where MEP/CSP is half‐maximal (MEP/CSP‐Int50), and correlated with Unified Parkinson's Disease Rating Scale scores (UPDRS). On the more affected side, higher (worse) UPDRS scores were correlated with shorter maximal CSP (r = −0.51, P = 0.046). On the less affected side, higher UPDRS scores were correlated with higher MEP‐Int50 (r = 0.51, P = 0.043) and CSP‐Int50 (r = 0.54, P = 0.029). For the less affected side, altered CE, as indexed by higher MEP or CSP‐Int50 intensities, may contribute to early clinical symptoms. On the more affected side, increases in CE, indexed by shorter CSP, may account for a greater proportion of PD symptoms. These findings are consistent with an evolution of neurophysiologic correlates in early PD patients from a less to more symptomatic state. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21565
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08-15">2007-08-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1587">1587</biblScope><biblScope unit="page" to="1593">1593</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B0D3792AD5312B338DF7FACA9465D174E63FAEAF</idno><idno type="DOI">10.1002/mds.21565</idno><idno type="ArticleID">MDS21565</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Dose-Response Relationship, Radiation</term><term>Electric Stimulation (methods)</term><term>Evoked Potentials, Motor (physiology)</term><term>Excitability</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor evoked potential</term><term>Nervous system diseases</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Silent period</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>cortical excitability</term><term>motor evoked potentials</term><term>silent period</term><term>transcranial magnetic stimulation.</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Humans</term><term>Inhibition (Psychology)</term><term>Male</term><term>Middle Aged</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Excitabilité</term><term>Parkinson maladie</term><term>Potentiel évoqué moteur</term><term>Période muette</term><term>Stimulation magnétique transcrânienne</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied corticomotor excitability (CE) between the more and less affected sides in early Parkinson's disease (PD) patients using transcranial magnetic stimulation (TMS). Sixteen‐PD patients within the first 3 years of diagnosis were studied with single‐pulse TMS over each motor cortex with intensities from 40% to 100% stimulator output. Active motor evoked potentials (MEP) and cortical silent period durations (CSP) were recorded, fitted with sigmoid curves, summarized as maximal MEP/CSP, maximal MEP/CSP slope, and intensity where MEP/CSP is half‐maximal (MEP/CSP‐Int50), and correlated with Unified Parkinson's Disease Rating Scale scores (UPDRS). On the more affected side, higher (worse) UPDRS scores were correlated with shorter maximal CSP (r = −0.51, P = 0.046). On the less affected side, higher UPDRS scores were correlated with higher MEP‐Int50 (r = 0.51, P = 0.043) and CSP‐Int50 (r = 0.54, P = 0.029). For the less affected side, altered CE, as indexed by higher MEP or CSP‐Int50 intensities, may contribute to early clinical symptoms. On the more affected side, increases in CE, indexed by shorter CSP, may account for a greater proportion of PD symptoms. These findings are consistent with an evolution of neurophysiologic correlates in early PD patients from a less to more symptomatic state. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name></region><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Kung, Myron" sort="Kung, Myron" uniqKey="Kung M" first="Myron" last="Kung">Myron Kung</name><name sortKey="Lin, Chien O J" sort="Lin, Chien O J" uniqKey="Lin C" first="Chien-Ho J." last="Lin">Chien-Ho J. Lin</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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