Asymmetric corticomotor excitability correlations in early Parkinson's disease
Identifieur interne : 004374 ( Main/Merge ); précédent : 004373; suivant : 004375Asymmetric corticomotor excitability correlations in early Parkinson's disease
Auteurs : Allan D. Wu [États-Unis] ; Giselle M. Petzinger [États-Unis] ; Chien-Ho J. Lin [États-Unis] ; Myron Kung [États-Unis] ; Beth Fisher [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
We studied corticomotor excitability (CE) between the more and less affected sides in early Parkinson's disease (PD) patients using transcranial magnetic stimulation (TMS). Sixteen-PD patients within the first 3 years of diagnosis were studied with single-pulse TMS over each motor cortex with intensities from 40% to 100% stimulator output. Active motor evoked potentials (MEP) and cortical silent period durations (CSP) were recorded, fitted with sigmoid curves, summarized as maximal MEP/CSP, maximal MEP/CSP slope, and intensity where MEP/CSP is half-maximal (MEP/CSP-Int50), and correlated with Unified Parkinson's Disease Rating Scale scores (UPDRS). On the more affected side, higher (worse) UPDRS scores were correlated with shorter maximal CSP (r = -0.51, P = 0.046). On the less affected side, higher UPDRS scores were correlated with higher MEP-Int50 (r = 0.51, P = 0.043) and CSP-Int50 (r = 0.54, P = 0.029). For the less affected side, altered CE, as indexed by higher MEP or CSP-Int50 intensities, may contribute to early clinical symptoms. On the more affected side, increases in CE, indexed by shorter CSP, may account for a greater proportion of PD symptoms. These findings are consistent with an evolution of neurophysiologic correlates in early PD patients from a less to more symptomatic state.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001566
- to stream PascalFrancis, to step Curation: 001755
- to stream PascalFrancis, to step Checkpoint: 001784
Links to Exploration step
Pascal:07-0448794Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Asymmetric corticomotor excitability correlations in early Parkinson's disease</title><author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Keck School of Medicine, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Lin, Chien Ho J" sort="Lin, Chien Ho J" uniqKey="Lin C" first="Chien-Ho J." last="Lin">Chien-Ho J. Lin</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Kung, Myron" sort="Kung, Myron" uniqKey="Kung M" first="Myron" last="Kung">Myron Kung</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Keck School of Medicine, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0448794</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 07-0448794 INIST</idno><idno type="RBID">Pascal:07-0448794</idno><idno type="wicri:Area/PascalFrancis/Corpus">001566</idno><idno type="wicri:Area/PascalFrancis/Curation">001755</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001784</idno><idno type="wicri:doubleKey">0885-3185:2007:Wu A:asymmetric:corticomotor:excitability</idno><idno type="wicri:Area/Main/Merge">004374</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Asymmetric corticomotor excitability correlations in early Parkinson's disease</title><author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Keck School of Medicine, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Lin, Chien Ho J" sort="Lin, Chien Ho J" uniqKey="Lin C" first="Chien-Ho J." last="Lin">Chien-Ho J. Lin</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Kung, Myron" sort="Kung, Myron" uniqKey="Kung M" first="Myron" last="Kung">Myron Kung</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, Keck School of Medicine, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California (USC)</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Excitability</term><term>Motor evoked potential</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Silent period</term><term>Transcranial magnetic stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Parkinson maladie</term><term>Excitabilité</term><term>Potentiel évoqué moteur</term><term>Période muette</term><term>Stimulation magnétique transcrânienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied corticomotor excitability (CE) between the more and less affected sides in early Parkinson's disease (PD) patients using transcranial magnetic stimulation (TMS). Sixteen-PD patients within the first 3 years of diagnosis were studied with single-pulse TMS over each motor cortex with intensities from 40% to 100% stimulator output. Active motor evoked potentials (MEP) and cortical silent period durations (CSP) were recorded, fitted with sigmoid curves, summarized as maximal MEP/CSP, maximal MEP/CSP slope, and intensity where MEP/CSP is half-maximal (MEP/CSP-Int50), and correlated with Unified Parkinson's Disease Rating Scale scores (UPDRS). On the more affected side, higher (worse) UPDRS scores were correlated with shorter maximal CSP (r = -0.51, P = 0.046). On the less affected side, higher UPDRS scores were correlated with higher MEP-Int50 (r = 0.51, P = 0.043) and CSP-Int50 (r = 0.54, P = 0.029). For the less affected side, altered CE, as indexed by higher MEP or CSP-Int50 intensities, may contribute to early clinical symptoms. On the more affected side, increases in CE, indexed by shorter CSP, may account for a greater proportion of PD symptoms. These findings are consistent with an evolution of neurophysiologic correlates in early PD patients from a less to more symptomatic state.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name></region><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Kung, Myron" sort="Kung, Myron" uniqKey="Kung M" first="Myron" last="Kung">Myron Kung</name><name sortKey="Lin, Chien Ho J" sort="Lin, Chien Ho J" uniqKey="Lin C" first="Chien-Ho J." last="Lin">Chien-Ho J. Lin</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004374 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004374 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:07-0448794
|texte= Asymmetric corticomotor excitability correlations in early Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |