Substantia nigra hypoechogenicity: Definition and findings in restless legs syndrome
Identifieur interne : 002B54 ( Main/Exploration ); précédent : 002B53; suivant : 002B55Substantia nigra hypoechogenicity: Definition and findings in restless legs syndrome
Auteurs : Jana Godau [Allemagne] ; Katherine J. Schweitzer [Allemagne] ; Inga Liepelt [Allemagne] ; Christian Gerloff [Allemagne] ; Daniela Berg [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Fer.
English descriptors
- KwdEn :
- Encephalon, Female, Homeostasis, Homeostasis (physiology), Humans, Iron, Iron (deficiency), Locus niger, Male, Middle Aged, Nervous system diseases, ROC Curve, Restless Legs Syndrome (epidemiology), Restless Legs Syndrome (physiopathology), Restless Legs Syndrome (ultrasonography), Restless legs syndrome, Severity of Illness Index, Sonography, Substantia Nigra (metabolism), Substantia Nigra (physiopathology), Substantia Nigra (ultrasonography), Ultrasonography, Doppler, Transcranial (methods), brain iron homeostasis, restless legs syndrome, substantia nigra, substantia nigra iron content, transcranial sonography.
- MESH :
- chemical , deficiency : Iron.
- epidemiology : Restless Legs Syndrome.
- metabolism : Substantia Nigra.
- methods : Ultrasonography, Doppler, Transcranial.
- physiology : Homeostasis.
- physiopathology : Restless Legs Syndrome, Substantia Nigra.
- ultrasonography : Restless Legs Syndrome, Substantia Nigra.
- Female, Humans, Male, Middle Aged, ROC Curve, Severity of Illness Index.
Abstract
Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age‐ and sex‐matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P < 0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides < 0.2 cm2) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area < 0.2 cm2), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21230
Affiliations:
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SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age‐ and sex‐matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P < 0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides < 0.2 cm2) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area < 0.2 cm2), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name></noRegion><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J." last="Schweitzer">Katherine J. Schweitzer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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