Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.
Identifieur interne : 002535 ( PubMed/Checkpoint ); précédent : 002534; suivant : 002536Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.
Auteurs : Jana Godau [Allemagne] ; Katherine J. Schweitzer ; Inga Liepelt ; Christian Gerloff ; Daniela BergSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Female, Homeostasis (physiology), Humans, Iron (deficiency), Male, Middle Aged, ROC Curve, Restless Legs Syndrome (epidemiology), Restless Legs Syndrome (physiopathology), Restless Legs Syndrome (ultrasonography), Severity of Illness Index, Substantia Nigra (metabolism), Substantia Nigra (physiopathology), Substantia Nigra (ultrasonography), Ultrasonography, Doppler, Transcranial (methods).
- MESH :
- chemical , deficiency : Iron.
- epidemiology : Restless Legs Syndrome.
- metabolism : Substantia Nigra.
- methods : Ultrasonography, Doppler, Transcranial.
- physiology : Homeostasis.
- physiopathology : Restless Legs Syndrome, Substantia Nigra.
- ultrasonography : Restless Legs Syndrome, Substantia Nigra.
- Female, Humans, Male, Middle Aged, ROC Curve, Severity of Illness Index.
Abstract
Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P < 0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides < 0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area < 0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications.
DOI: 10.1002/mds.21230
PubMed: 17133515
Affiliations:
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Schweitzer</name></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21230</idno><idno type="RBID">pubmed:17133515</idno><idno type="pmid">17133515</idno><idno type="wicri:Area/PubMed/Corpus">002963</idno><idno type="wicri:Area/PubMed/Curation">002963</idno><idno type="wicri:Area/PubMed/Checkpoint">002535</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.</title><author><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><affiliation wicri:level="1"><nlm:affiliation>Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Schweitzer, Katherine J" sort="Schweitzer, Katherine J" uniqKey="Schweitzer K" first="Katherine J" last="Schweitzer">Katherine J. Schweitzer</name></author><author><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name></author><author><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name></author><author><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Homeostasis (physiology)</term><term>Humans</term><term>Iron (deficiency)</term><term>Male</term><term>Middle Aged</term><term>ROC Curve</term><term>Restless Legs Syndrome (epidemiology)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Restless Legs Syndrome (ultrasonography)</term><term>Severity of Illness Index</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (physiopathology)</term><term>Substantia Nigra (ultrasonography)</term><term>Ultrasonography, Doppler, Transcranial (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ultrasonography, Doppler, Transcranial</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Homeostasis</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Restless Legs Syndrome</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Restless Legs Syndrome</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>ROC Curve</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P < 0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides < 0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area < 0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17133515</PMID><DateCreated><Year>2007</Year><Month>02</Month><Day>05</Day></DateCreated><DateCompleted><Year>2007</Year><Month>03</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.</ArticleTitle><Pagination><MedlinePgn>187-92</MedlinePgn></Pagination><Abstract><AbstractText>Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2 independent and blinded examiners to determine the area of SN echogenicity. We found that SN echogenicity is significantly decreased in RLS patients compared to healthy controls (P < 0.001). SN hypoechogenicity (sum area of SN echogenicity of both sides < 0.2 cm(2)) is more common in idiopathic than in secondary RLS patients. The area under curve for idiopathic RLS versus controls (receiver operating characteristics) is 0.91, specificity is 0.90, and sensitivity is 0.82. TCS provides an interesting additional instrument in the diagnosis of RLS. Therefore, SN hypoechogenicity (SN sum area < 0.2 cm(2)), which is supposed to indicate a decreased SN iron content, is a marker for RLS. 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Schweitzer</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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