Nigral burden of α‐synuclein correlates with striatal dopamine deficit
Identifieur interne : 002732 ( Main/Exploration ); précédent : 002731; suivant : 002733Nigral burden of α‐synuclein correlates with striatal dopamine deficit
Auteurs : Gabor G. Kovacs [Autriche] ; Ivan J. Milenkovic [Autriche] ; Matthias Preusser [Autriche] ; Herbert Budka [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Dopamine, Dopamine (deficiency), Dopamine Plasma Membrane Transport Proteins (metabolism), Encephalon, Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (pathology), Parkinson disease, Postmortem Changes, Substantia Nigra (metabolism), alpha-Synuclein (metabolism), brain imaging, dopamine transporter, striatum, α‐synuclein.
- MESH :
- chemical , deficiency : Dopamine.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins, alpha-Synuclein.
- metabolism : Substantia Nigra.
- pathology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Postmortem Changes.
Abstract
Aggregated α‐synuclein is the hallmark of Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and multiple system atrophy (MSA). Physiologically, α‐synuclein ensures normal functions of dopamine transporter (DAT) and tyrosine hydoxylase. In α‐synucleinopathies, it accumulates in neuronal cytoplasm and neurites through several stages. It is unclear whether the accumulation of pathological α‐synuclein in the substantia nigra in PD correlates with the dopaminergic deficit in the striatal target. We evaluated the impact of the nigral burden of pathological α‐synuclein immunoreactivity in 27 α‐synucleinopathy brains by morphometric immunohistochemistry. DAT immunoreactivity in the striatum inversely correlates with the total α‐synuclein burden in the substantia nigra but not with cytoplasmic inclusion counts only. This result has implications for imaging, clinicopathological correlative studies, and staging of the disease process. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22207
Affiliations:
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