MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 001165

Nigral Burden of α-Synuclein Correlates with Striatal Dopamine Deficit

Identifieur interne : 001165 ( PascalFrancis/Checkpoint ); précédent : 001164; suivant : 001166

Nigral Burden of α-Synuclein Correlates with Striatal Dopamine Deficit

Auteurs : Gabor G. Kovacs [Autriche] ; Ivan J. Milenkovic [Autriche] ; Matthias Preusser [Autriche] ; Herbert Budka [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0450176

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Dopamine, Encéphale.

English descriptors

KwdEn :
- Dopamine, Encephalon, Nervous system diseases, Parkinson disease.

Abstract

Aggregated α-synuclein is the hallmark of Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and multiple system atrophy (MSA). Physiologically, α-synuclein ensures normal functions of dopamine transporter (DAT) and tyrosine hydoxylase. In α-synucleinopathies, it accumulates in neuronal cytoplasm and neurites through several stages. It is unclear whether the accumulation of pathological α-synuclein in the substantia nigra in PD correlates with the dopaminergic deficit in the striatal target. We evaluated the impact of the nigral burden of pathological α-synuclein immunoreactivity in 27 α-synucleinopathy brains by morphometric immunohistochemistry. DAT immunoreactivity in the striatum inversely correlates with the total α-synuclein burden in the substantia nigra but not with cytoplasmic inclusion counts only. This result has implications for imaging, clinicopathological correlative studies, and staging of the disease process.

Affiliations:

Autriche

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Pascal:08-0450176

Le document en format XML

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	Movement Disorders (revue)
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Movement Disorders (revue)

Nigral Burden of α-Synuclein Correlates with Striatal Dopamine Deficit

Nigral Burden of α-Synuclein Correlates with Striatal Dopamine Deficit

Source :

Descripteurs français

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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