Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease
Identifieur interne : 002684 ( Main/Exploration ); précédent : 002683; suivant : 002685Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson's disease
Auteurs : Bart F. L. Van Nuenen [Pays-Bas] ; Rianne A. J. Esselink [Pays-Bas] ; Marten Munneke [Pays-Bas] ; Johhannes D. Speelman [Pays-Bas] ; Teus Van Laar [Pays-Bas] ; Bastiaan R. Bloem [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Deep Brain Stimulation (adverse effects), Deep brain stimulation, Deterioration, Female, Follow-Up Studies, Gait Disorders, Neurologic (etiology), Humans, Male, Nervous system diseases, Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Postoperative, Postoperative Period, Questionnaires, Retrospective Studies, Subthalamic Nucleus (physiology), Subthalamic nucleus, deep brain stimulation, gait.
- MESH :
- adverse effects : Deep Brain Stimulation.
- etiology : Gait Disorders, Neurologic.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Female, Follow-Up Studies, Humans, Male, Postoperative Period, Questionnaires, Retrospective Studies.
Abstract
Deep brain stimulation of the subthalamic nuclei (STN) is a good therapeutic option to reduce dyskinesias and improve appendicular motor signs in well‐selected patients with advanced Parkinson's disease (PD). Concerns about long‐term adverse effects play an increasingly role in the decision whether or not to refer patients for this treatment. Worsening of gait as a consequence of STN stimulation for PD has been described, but may be under‐recognized in clinical practice. The aim of this study was to evaluate the effects of STN stimulation on gait relative to global outcome in a group of consecutively operated patients. For this purpose, we used a standardized patient questionnaire that asked about global outcome and specific effects on gait, as experienced both 6 months postoperatively and currently (at the time of completing the questionnaire; mean: 2.7 +/− 1.1 years). A delayed worsening of gait after bilateral STN stimulation was experienced by a considerable proportion of patients (42% of subjects, for gait in the OFF phase), and this was apparently relatively “selective” because their global outcome scores continued to be improved. These findings highlight the presence of a hitherto poorly recognized long‐term complication of bilateral STN stimulation. Further systematic studies are required to pinpoint the clinical and surgical determinants of this late gait deterioration. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21986
Affiliations:
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Le document en format XML
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Concerns about long‐term adverse effects play an increasingly role in the decision whether or not to refer patients for this treatment. Worsening of gait as a consequence of STN stimulation for PD has been described, but may be under‐recognized in clinical practice. The aim of this study was to evaluate the effects of STN stimulation on gait relative to global outcome in a group of consecutively operated patients. For this purpose, we used a standardized patient questionnaire that asked about global outcome and specific effects on gait, as experienced both 6 months postoperatively and currently (at the time of completing the questionnaire; mean: 2.7 +/− 1.1 years). A delayed worsening of gait after bilateral STN stimulation was experienced by a considerable proportion of patients (42% of subjects, for gait in the OFF phase), and this was apparently relatively “selective” because their global outcome scores continued to be improved. These findings highlight the presence of a hitherto poorly recognized long‐term complication of bilateral STN stimulation. Further systematic studies are required to pinpoint the clinical and surgical determinants of this late gait deterioration. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Groningue (province)</li><li>Gueldre</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Groningue</li><li>Nimègue</li></settlement></list><tree><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Van Nuenen, Bart F L" sort="Van Nuenen, Bart F L" uniqKey="Van Nuenen B" first="Bart F. L." last="Van Nuenen">Bart F. L. Van Nuenen</name></region><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name><name sortKey="Esselink, Rianne A J" sort="Esselink, Rianne A J" uniqKey="Esselink R" first="Rianne A. J." last="Esselink">Rianne A. J. Esselink</name><name sortKey="Esselink, Rianne A J" sort="Esselink, Rianne A J" uniqKey="Esselink R" first="Rianne A. J." last="Esselink">Rianne A. J. Esselink</name><name sortKey="Munneke, Marten" sort="Munneke, Marten" uniqKey="Munneke M" first="Marten" last="Munneke">Marten Munneke</name><name sortKey="Speelman, Johhannes D" sort="Speelman, Johhannes D" uniqKey="Speelman J" first="Johhannes D." last="Speelman">Johhannes D. Speelman</name><name sortKey="Van Laar, Teus" sort="Van Laar, Teus" uniqKey="Van Laar T" first="Teus" last="Van Laar">Teus Van Laar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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