Essential tremor in Parkinson's disease kindreds from a population of similar genetic background
Identifieur interne : 002321 ( Main/Exploration ); précédent : 002320; suivant : 002322Essential tremor in Parkinson's disease kindreds from a population of similar genetic background
Auteurs : Cleanthe Spanaki [Grèce] ; Andreas Plaitakis [Grèce]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-08-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Brain (radionuclide imaging), Crete, Essential Tremor (epidemiology), Essential Tremor (genetics), Essential Tremor (radionuclide imaging), Family Health, Female, Genetic Predisposition to Disease, Greece (epidemiology), Humans, Iodine Radioisotopes (diagnostic use), Male, Middle Aged, Nervous system diseases, Nortropanes (diagnostic use), Parents, Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Pedigree, Radiopharmaceuticals (diagnostic use), Sex Factors, Siblings, Tomography, Emission-Computed, Single-Photon, Tremor, essential tremor, pedigrees.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Nortropanes, Radiopharmaceuticals.
- geographic , epidemiology : Greece.
- epidemiology : Essential Tremor, Parkinson Disease.
- genetics : Essential Tremor, Parkinson Disease.
- radionuclide imaging : Brain, Essential Tremor, Parkinson Disease.
- Adult, Age of Onset, Aged, Family Health, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parents, Pedigree, Sex Factors, Siblings, Tomography, Emission-Computed, Single-Photon.
Abstract
To investigate the possible association between essential tremor (ET) and Parkinson's disease (PD) we conducted a prospective clinical and epidemiological study in a population of similar genetic background. The first‐degree relatives of 303 PD probands and 249 controls from Crete were evaluated for the presence of ET. In addition, the possible co‐occurrence of ET and PD in the same family or in the same individual was investigated. Results showed that ET was present in the relatives of PD patients more often than in those of controls (OR:3.64, P < 0.001). The risk was even greater (OR: 4.48) when the affected proband had tremor‐dominant or mixed PD. Female relatives and siblings of PD patients were more likely to have ET than male relatives and parents of PD patients (OR: 4.36 v/s 2.89 and 4.49 v/s 2.74, respectively). Twelve subjects had both ET and PD phenotypes. While this may have occurred by chance, a number of families were identified in which ET and PD were coinherited through the same parental line. Hence, in certain families ET and PD are genetically related probably sharing common hereditary predisposition. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22655
Affiliations:
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Le document en format XML
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The first‐degree relatives of 303 PD probands and 249 controls from Crete were evaluated for the presence of ET. In addition, the possible co‐occurrence of ET and PD in the same family or in the same individual was investigated. Results showed that ET was present in the relatives of PD patients more often than in those of controls (OR:3.64, P < 0.001). The risk was even greater (OR: 4.48) when the affected proband had tremor‐dominant or mixed PD. Female relatives and siblings of PD patients were more likely to have ET than male relatives and parents of PD patients (OR: 4.36 v/s 2.89 and 4.49 v/s 2.74, respectively). Twelve subjects had both ET and PD phenotypes. While this may have occurred by chance, a number of families were identified in which ET and PD were coinherited through the same parental line. 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